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Upstream Process Engineer Jobs in Massachusetts (NOW HIRING)

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Emergent Biosolutions

Sr Engineer, Process

Canton, MA

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

New

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

New

Syner-G

Process Engineer

Plainville, MA · On-site

Strong understanding of upstream, downstream, fill-finish, or related manufacturing processes ... Demonstrated experience supporting engineering runs, qualification activities, and manufacturing ...

Integrated Resources INC

Biprocess Engineer

Devens, MA · On-site

Process Engineer Scientific: * MS&T organization is seeking to fill a Process Engineer position for ... Preferred: Prior experience scaling up biopharma manufacturing processes (upstream/downstream ...

Syner-G

Sr. Process Engineer

Bedford, MA

$109K - $141K/yr

... upstream and downstream manufacturing processes. * Provide technical leadership during facility ... Support process engineering activities related to lyophilization cycle development, process ...

Syner-G

Sr. Process Engineer

Bedford, MA · On-site

$109K - $141K/yr

... upstream and downstream manufacturing processes. * Provide technical leadership during facility ... Support process engineering activities related to lyophilization cycle development, process ...

Syner-G

Sr. Process Engineer

Bedford, MA · On-site

$109K - $141K/yr

... upstream and downstream manufacturing processes. * Provide technical leadership during facility ... Support process engineering activities related to lyophilization cycle development, process ...

Syner-G

Principal Process Engineer

Norwood, MA · On-site

The Principal Process Engineer will guide cross-functional teams, mentor engineering staff, and ... Lead enterprise-level process development, optimization, and scale-up initiatives across upstream ...

Sartorius AG

Process Technology Engineer

Marlborough, MA · On-site

$95K - $120K/yr

Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle-from customer discovery through project execution. You will ...

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All JobsUpstream Process Engineer JobsUpstream Process Engineer Jobs in Massachusetts

Upstream Process Engineer information

See Massachusetts salary details

$54.1K

$100.5K

$155.6K

How much do upstream process engineer jobs pay per year?

As of Aug 21, 2026, the average yearly pay for upstream process engineer in Massachusetts is $100,495.00, according to ZipRecruiter salary data. Most workers in this role earn between $81,400.00 and $112,500.00 per year, depending on experience, location, and employer.

What does an upstream process engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the typical daily responsibilities of an upstream process engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.

What are the key skills and qualifications needed to thrive as an upstream process engineer, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are popular job titles related to Upstream Process Engineer jobs in Massachusetts?

For Upstream Process Engineer jobs in Massachusetts, the most frequently searched job titles are:

What job categories do people searching Upstream Process Engineer jobs in Massachusetts look for?

The top searched job categories for Upstream Process Engineer jobs in Massachusetts are:

What cities in Massachusetts are hiring for Upstream Process Engineer jobs?

Cities in Massachusetts with the most Upstream Process Engineer job openings:

Upstream Process Engineer jobs near you
Infographic showing various Upstream Process Engineer job openings in Massachusetts as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 13% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $100,495 per year, or $48.3 per hour.

Process Engineer - Upstream/Downstream

Integrated Resources INC

Devens, MA • On-site

Contractor

Re-posted 2 days ago

Job description

Company Description

Client is a global bio-pharmaceutical company

Job Description

The successful candidate will provide meaningful contributions toward commercial manufacturing support, process monitoring, technology transfer and process validation activities. The successful candidate will have a demonstrated background in bioprocessing (upstream and/or downstream), experience troubleshooting manufacturing processes and strong technical documentation skills (memos, protocols, reports).

Responsibilities:

Work independently to provide commercial manufacturing technical support, process monitoring, technology transfer and process validation activities for downstream processes.

Provide process troubleshooting during scale-up and routine manufacturing.

Provide process subject matter expertise and ownership of assigned deliverables.

The successful candidate will work effectively in highly cross-functional project teams, matrix management environments, as well as independent working environments to support the site.

Perform data analysis and monitoring for process performance and product quality outputs.

The position will interface with Manufacturing, Quality, Engineering, and internal MS&T departments at multiple sites throughout the Client network

Strong communication and technical writing skills are required.

Qualifications

B.S./M.S. or Ph.D. in Chemical Engineer, Biochemical Engineer, Biomedical Engineer, Biochemistry or related field (Advanced degree is preferred)

Required: Prior experience (Ph.D: 0 - 2 years; BS/MS: 2 - 6 years) in process development, process validation or manufacturing support in bioprocessing (upstream and/or downstream)

Preferred: Prior experience scaling up biopharma manufacturing processes (upstream/downstream), facility fit assessments, process scale-up from bench/pilot to production, process troubleshooting and optimization, and process validation.

Hands-on experience working with chromatography, ultrafiltration and depth filtration process acquired through lab, pilot or production scale experience.

Preferred: Experience performing manufacturing investigations for biologics manufacturing.

Preferred: Experience providing start-up support for new biologics manufacturing processes (Person-In-Plant)

Preferred: Experience with statistical methodologies (DOE, SPC, etc), cGMP regulations, and regulatory requirements is expected.

Additional Information

All your information will be kept confidential according to EEO guidelines.

Integrated Resources logo

About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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