Upstream Process Engineer Jobs in Massachusetts (NOW HIRING)

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Job Description
About the role
The Process Development Engineer II supports biotherapeutics process development by executing hands-on cell culture and upstream development experiments. This role involves planning and running studies across a range of upstream unit operations, including bench-top bioreactors, Ambr microscale bioreactors, shake flasks, WAVE bioreactors, and high-throughput purification systems.
You will collaborate with senior process engineers to execute complex studies while partnering closely with the broader process development team to generate high-quality data, maintain accurate documentation, and contribute to the optimization of upstream processes. This role also supports laboratory operations by ensuring equipment readiness and reliability.
How you will contribute

• Execute and monitor experiments using cell culture and upstream unit operations (bench-top bioreactors, Ambr, shake flasks, WAVE bioreactors, high-throughput purification systems)
• Operate and monitor bioprocess equipment using DeltaV or similar process control systems
• Maintain laboratory equipment and ensure day-to-day operational readiness
• Partner with senior engineers to plan and execute larger studies and experiments
• Document experimental work in electronic laboratory notebooks with clear, accurate, and timely records
• Perform basic data analysis to evaluate trends and support study conclusions
• Prepare technical summaries and study updates to communicate findings
• Adhere to laboratory procedures, quality standards, and safety requirements
• Support continuous improvement efforts related to workflows, data capture, and execution
• Contribute to project tasks and small initiatives under guidance

What you bring to Takeda

• Associate's degree with 2+ years of relevant experience, or Bachelor's degree in chemical engineering, biological engineering, biotechnology, biology, or a related field, with relevant laboratory or process development experience
• Experience in cell culture, upstream process development, or biotherapeutics development
• Hands-on experience with bioreactors, shake flasks, or related upstream platforms
• Familiarity with DeltaV or similar process control systems
• Experience using electronic laboratory notebooks for documentation
• Ability to perform basic data analysis and clearly communicate findings
• Strong technical writing skills for reports and documentation
• Understanding of laboratory practices, development processes, and quality requirements
• Strong attention to detail with the ability to follow procedures and maintain accurate records
• Ability to work effectively under guidance in a collaborative team environment

More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Empowering our people to shine:
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
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Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Lexington, MA
U.S. Base Salary Range:
$71,800.00 - $112,860.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Lexington, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.