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Upstream Process Engineer Jobs in Boston, MA (NOW HIRING)

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Emergent Biosolutions

Sr Engineer, Process

Canton, MA

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Syner-G

Process Engineer

Plainville, MA · On-site

Strong understanding of upstream, downstream, fill-finish, or related manufacturing processes ... Demonstrated experience supporting engineering runs, qualification activities, and manufacturing ...

Syner-G

Sr. Process Engineer

Bedford, MA · On-site

$109K - $141K/yr

... upstream and downstream manufacturing processes. * Provide technical leadership during facility ... Support process engineering activities related to lyophilization cycle development, process ...

Syner-G

Sr. Process Engineer

Bedford, MA · On-site

$109K - $141K/yr

... upstream and downstream manufacturing processes. * Provide technical leadership during facility ... Support process engineering activities related to lyophilization cycle development, process ...

Sartorius AG

Process Technology Engineer

Marlborough, MA · On-site

$95K - $120K/yr

Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle-from customer discovery through project execution. You will ...

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All JobsUpstream Process Engineer JobsUpstream Process Engineer Jobs in Boston, MA

Upstream Process Engineer information

See Boston, MA salary details

$53.8K

$100K

$154.8K

How much do upstream process engineer jobs pay per year?

As of Aug 26, 2026, the average yearly pay for upstream process engineer in Boston, MA is $99,968.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,900.00 and $111,900.00 per year, depending on experience, location, and employer.

What does an upstream process engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the typical daily responsibilities of an upstream process engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.

What are the key skills and qualifications needed to thrive as an upstream process engineer, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are popular job titles related to Upstream Process Engineer jobs in Boston, MA?

For Upstream Process Engineer jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Upstream Process Engineer jobs in Boston, MA look for?

The top searched job categories for Upstream Process Engineer jobs in Boston, MA are:

Upstream Process Engineer jobs near you
Infographic showing various Upstream Process Engineer job openings in Boston, MA as of August 2026, with employment types broken down into 90% Full Time, and 10% Contract. Highlights an 83% In-person, 10% Hybrid, and 7% Remote job distribution, with an average salary of $99,968 per year, or $48.1 per hour.

Upstream Process Development Scientist (Cell Culture, Bioreactors)

Andover, MA • On-site

Pioneer Data
See more jobs at Pioneer Dataexternal

Contractor

Re-posted 8 days ago

Job description

Position Details: 
Our client, a world-leading Pharmaceutical Company in Andover, MA is currently looking for a Upstream Process Development Scientist (Cell Culture, Bioreactors) to join their expanding team.
 
Job Title: Upstream Process Development Scientist (Cell Culture, Bioreactors)
Duration: 12 months contract, extendable up to 48 months
Location: Andover, MA
 
Note: 
The client has the right-to-hire you as a permanent employee at any time during or after the end of the contract.
You may participate in the company group medical insurance plan
 
Job Description:
Summary:
Manufacturing Sciences and Technology (MSAT) at client is looking for a highly motivated, versatile candidate to join our multidisciplinary team of scientists and engineers in Andover, MA. 
The group supports Pfizer’s portfolio of late stage development and commercial biopharmaceuticals and vaccines, and is responsible for process troubleshooting, process improvements and second- generation process development. 
We are looking for someone who is eager to contribute independent thinking and technical excellence to the upstream cell culture mammalian team.
The ideal candidate will be a valuable contributor to the upstream team within MSAT Andover. 
The role is well-integrated with the rest of the MSAT group and will involve a lot of collaborative work both within the group and across the Andover site. 
The colleague will be expected to plan and execute well-designed lab experiments in cell culture with pre-defined goals. This includes basic analytics, data acquisition and interpretation, user-level maintenance of the relevant equipment and documentation of work.
 
Job Responsibilities:
Plan and execute upstream mammalian process experiments at laboratory scales.
Operate and maintain laboratory bioreactors and associated analytic tools.
Understand and (as necessary) adjust control and data acquisition systems.
Document results and present them to internal teams.
Assist in manufacturing investigations and process troubleshooting.
 
Qualifications:
Bachelor’s degree in a relevant discipline with 3 years of applicable bioprocess experience.
Proficient in aseptic technique (required).
Experience in laboratory bioreactor operation and associated analytical tools (required).
Familiarity with control and data acquisition systems.
Knowledge of all aspects of cell culture bioreactor operation modes, i.e. batch, fed-batch, continuous.
Experience with processing and interpreting large data sets.
Involves typical bioprocessing lab activities (Examples: Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis).
 
Additional Qualifications:
May require some out of hours working to support laboratory and off hours cell culture work, e.g weekend coverage once a month.