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Upstream Process Engineer Jobs in Boston, MA (NOW HIRING)

UCB

Scientist II - Molecular Analytics & NGS

Boston, MA · Hybrid

$99K - $130K/yr

... II in Upstream Process Development and Bioprocess Analytics team to support genetic medicine ... engineering * Function independently and cross functionally across various UCB teams (data ...

UCB

Scientist II - Molecular Analytics & NGS

Boston, MA · On-site

$99K - $130K/yr

... II in Upstream Process Development and Bioprocess Analytics team to support genetic medicine ... engineering * Function independently and cross functionally across various UCB teams (data ...

ElevateBio

Biomanufacturing Associate II

Waltham, MA · On-site

$38 - $52/hr

... upstream processing, downstream processing, aseptic fill finish and final product visual inspection ... Bachelor's degree in biological science(s) field or related engineering with 2-4 years of ...

Motional

Senior Engineer

Boston, MA · On-site +1

$200K - $241K/yr

Interface with upstream and downstream components through continuous integration and continuous ... Owning and leading technical development on features, * leading processes from problem formulation ...

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Upstream Process Engineer information

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$100K

$154.8K

How much do upstream process engineer jobs pay per year?

As of Aug 6, 2026, the average yearly pay for upstream process engineer in Boston, MA is $99,968.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,900.00 and $111,900.00 per year, depending on experience, location, and employer.

What does an upstream process engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the key skills and qualifications needed to thrive as an upstream process engineer, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are the typical daily responsibilities of an upstream process engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.

What are popular job titles related to Upstream Process Engineer jobs in Boston, MA? For Upstream Process Engineer jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Upstream Process Engineer jobs in Boston, MA look for? The top searched job categories for Upstream Process Engineer jobs in Boston, MA are:
Upstream Process Engineer jobs near you
Infographic showing various Upstream Process Engineer job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $99,968 per year, or $48.1 per hour.

Sr. Product Manager, Upstream Filtration Systems

Repligen Corporation

Marlborough, MA • On-site

$125K - $160K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 19 days ago

Repligen rating

7.6

Company rating: 7.6 out of 10

Based on 13 frontline employees who took The Breakroom Quiz

Job description

Make a global impact-join Repligen.
We're united by a mission to inspire advances in bioprocessing as a preferred partner in the production of biologic drugs that improve human health worldwide. No matter your role or background, at Repligen, you will play a key part in shaping some of the most innovative and life-changing therapies in the world. We foster a culture of purpose, collaboration, and shared success-where every voice matters and every contribution drives progress. Join us!
This role will lead the upstream filtration products including ATF and TFDF systems used for bioprocessing applications. Systems will be semiautomatic and fully automatic functionalities including ATF and TFDF controllers/hardware/software and the associated accessories.
This role will be responsible for driving and ensuring the long-term success of the upstream hardware business including. He/she will be responsible for understanding the market needs, understanding competition and accordingly drive our ATF and TFDF systems design efforts that are highly competitive and meet/exceed customer needs. This will be a "hands-on" position focused on developing and implementing product strategies to accelerate growth and profitability. Working externally with the sales team, this position will be responsible for driving the Technology adoption and driving the internal organization to support and expand the product range. This individual will take a leadership cross-functional role working with at minimum marketing, sales, manufacturing, operations, support, applications, and product development. Key metrics include; revenue growth, new application penetration, profitability, new product releases.
Responsibilities
  • Derive strategy and tactics, and manage the product life cycle to ensure YOY business growth and strong customer satisfaction
  • Support the global Sales organization, providing effective product positioning, sales tools, training, competitive analysis and in-field support as needed
  • Analyze and respond to technical questions related to product use and performance, product quality, and service features
  • Create and drive commercial strategy for New Product releases
  • Derive forecast to ensure accurate demand planning, product build and revenue attainment
  • Be responsible for assessing business performance through KPI tracking
  • Collaborate with sales and engineering to develop new or improve existing products based on VOC
  • Work with Operations and Customer Service to ensure on timely delivery of products and services
  • Drive resolution of customer inquiries and complaints with required internal functions including Quality, Supply Chain, Manufacturing and R&D
  • Develop and recommend appropriate pricing and discounting
  • Assess business performance through KPI tracking
  • Liaise with Marketing to develop effective product collateral and campaigns

Qualifications
  • A BS degree or higher in an engineering or science discipline, with MBA is preferred
  • A minimum of 7-10 years of experience in commercial product management, business management or sales and marketing
  • Experience with hardware/equipment and filtration operations in bioprocessing is preferred
  • Customer facing experience and the ability to build mutually beneficial, trusting relationships with internal and external stakeholders
  • Strong attention to detail with excellent verbal and written communication skills
  • Ability to take initiative, hold team members accountable for deliverables, and obtain support across departments
  • Strategic, tactical and analytical thinking
  • Ability to travel (including global travel), up to 20%
  • Proficient in MS Office Suite (Word, Excel, PowerPoint, Project and Visio)

Our mission is to inspire advances in bioprocessing as a trusted partner in the production of biologic drugs that improve human health worldwide. Focused on cost and process efficiencies, we deliver innovative technologies and solutions that help set new standards in bioprocessing. The estimated base salary range for this role, based in the United States of America is $125,000 - 160,000.00. Compensation decisions are dependent on several factors including, but not limited to an individual's qualifications, location, internal equity, and alignment with market data. Additionally, employees are eligible to participate in one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits such as paid time off, health/dental/vision, retirement benefits and flexible spending accounts. All compensation and benefits information will be confirmed in writing at the time of offer.

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