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Upstream Process Engineer Jobs in Massachusetts (NOW HIRING)

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Upstream Process Engineer information

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$54.1K

$100.5K

$155.6K

How much do upstream process engineer jobs pay per year?

As of Aug 21, 2026, the average yearly pay for upstream process engineer in Massachusetts is $100,495.00, according to ZipRecruiter salary data. Most workers in this role earn between $81,400.00 and $112,500.00 per year, depending on experience, location, and employer.

What does an upstream process engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the typical daily responsibilities of an upstream process engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.

What are the key skills and qualifications needed to thrive as an upstream process engineer, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are popular job titles related to Upstream Process Engineer jobs in Massachusetts?

For Upstream Process Engineer jobs in Massachusetts, the most frequently searched job titles are:

What job categories do people searching Upstream Process Engineer jobs in Massachusetts look for?

The top searched job categories for Upstream Process Engineer jobs in Massachusetts are:

What cities in Massachusetts are hiring for Upstream Process Engineer jobs?

Cities in Massachusetts with the most Upstream Process Engineer job openings:

Upstream Process Engineer jobs near you
Infographic showing various Upstream Process Engineer job openings in Massachusetts as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 13% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $100,495 per year, or $48.3 per hour.

Research Associate - Process Development

Artis BioSolutions

Watertown, MA • On-site

Full-time

Posted 13 days ago

Job description

The Process Development department at Landmark Bio/Artis BioSolutions supports a growing portfolio of advanced cell and gene therapies (CGT), including CAR-T, iPSC, AAV, LVV, and synthetic DNA products. We are immediately hiring a highly motivated Research Associate - Process Development to support the development and optimization of innovative manufacturing processes for advanced therapies.

In this role, you will execute hands-on cell culture and process development experiments, maintain cell lines, optimize culture conditions, analyze experimental data, and support the development and scale-up of robust manufacturing processes. You will collaborate closely with Process Development, Analytical Development, Manufacturing, Engineering, and Quality teams to advance programs from development through technology transfer and GMP manufacturing.

This is an exciting opportunity to join a fast-paced, collaborative team focused on translating cutting-edge research into life-changing medicines. This hands-on, lab-based role requires working on-site at Landmark Bio/Artis BioSolutions in Watertown, MA, with a flexible schedule based on experimental needs.

Responsibilities

  • Cell Culture: Perform mammalian cell culture activities including aseptic technique, media and buffer preparation, culture initiation, propagation, expansion, and cryopreservation.

  • Cell-Based Process Development: Culture and process a variety of cell types, including iPSC, MSC, and primary human cells.

  • Bioreactor Operations: Support the operation, monitoring, and optimization of bioreactor systems and associated upstream processes.

  • Genetic Manipulation: Perform cell transfection, transduction, and other genetic modification techniques using relevant viral and non-viral systems.

  • Process Optimization: Execute experiments to evaluate and optimize culture conditions, process parameters, yields, and overall process performance.

  • Experimental Execution: Prepare and execute laboratory protocols, collect samples, analyze experimental results, and troubleshoot technical challenges.

  • Technology Transfer: Support process scale-up, engineering runs, and transfer of developed processes into GMP manufacturing.

  • Documentation: Maintain accurate and reliable records including electronic laboratory notebooks, batch records, databases, protocols, and other technical documentation.

  • Technical Writing: Draft and/or contribute to SOPs, protocols, batch records, technical reports, and process development documentation.

  • Laboratory Operations: Perform routine laboratory activities including equipment maintenance, inventory management, and maintaining laboratory readiness.

  • Safety & Compliance: Follow all environmental health and safety, infection control, quality, and applicable regulatory requirements.

Qualifications

  • Education: Bachelor's degree in Biology, Bioengineering, Biotechnology, Biochemistry, Chemical Engineering, or a related scientific discipline.

  • Experience: 1-2+ years of relevant laboratory, biotechnology, or process development experience. Equivalent advanced-degree academic research experience may also be considered.

  • Cell Culture: Strong understanding of mammalian cell culture and aseptic techniques.

  • Technical Experience: Hands-on experience with cell culture, cell expansion, cryopreservation, transfection, transduction, or related process development techniques.

  • Viral Vectors: Willingness to work with viral vector systems, including lentiviral and AAV vectors, as well as biological samples.

  • Bioprocessing: Experience with bioreactors and/or other cell-based process development technologies is preferred.

  • Problem-Solving: Strong analytical and troubleshooting skills with the ability to interpret experimental data and contribute to process improvements.

  • Collaboration: Highly motivated team player who can also work independently in a fast-paced laboratory environment.

  • Communication: Strong verbal and written communication skills with excellent attention to detail

Landmark Bio/Artis BioSolutions is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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