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Upstream Process Engineer Jobs (NOW HIRING)

ERMCO

Technical Process Engineer

Dyersburg, TN

... on upstream process behavior * Monitor and communicate performance trends, clearly linking ... Bachelor's degree in Engineering (Industrial, Mechanical, Manufacturing, Electrical, or related ...

Quality Agents

Process Engineer

Rockville, MD · On-site

The ideal candidate brings hands-on experience in biotech or pharmaceutical process engineering, with a focus on upstream, downstream or cell therapy operations. Key Responsibilities Support the ...

Quality Agents, LLC

Process Engineer

Rockville, MD

The ideal candidate brings hands-on experience in biotech or pharmaceutical process engineering, with a focus on upstream, downstream or cell therapy operations. Key Responsibilities Support the ...

Raya Workforce

Process Engineer

Lincoln, NE · On-site

Process Engineer - Biotech Location: Lincoln, NE Employment Type: Contract 1099| On-site Contract ... Drive improvements across upstream manufacturing and downstream packaging * Support line trials ...

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How much do upstream process engineer jobs pay per year?

As of May 30, 2026, the average yearly pay for upstream process engineer in the United States is $92,018.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,500.00 and $103,000.00 per year, depending on experience, location, and employer.

What does an Upstream Process Engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the key skills and qualifications needed to thrive in the Upstream Process Engineer position, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are the typical daily responsibilities of an Upstream Process Engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.
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Upstream Process Engineer jobs near you
Principal Scientist, Late Stage Upstream Process Development (San Francisco, CA)

Principal Scientist, Late Stage Upstream Process Development (San Francisco, CA)

CEDENT

San Francisco, CA

Other

Posted 5 days ago

Job description

Client is seeking an experienced and driven scientist/engineer to lead late-stage upstream cell culture process development activities for clinical and commercial-stage large molecule programs. This individual will serve as the upstream lead for scale-up and tech transfer to manufacturing sites, establishing process validation (PV) strategy and PPQ/post-approval process support. Key Accountabilities/ Core Job Responsibilities Lead scale-up and tech transfer of the upstream process to manufacturing sites, ensuring alignment with control strategy and regulatory filings.

Serve as the technical lead, responsible for upstream process activities for a late-stage large molecule programs including commercial manufacturing support Author and review relevant CMC documentation including PV protocols/reports and regulatory sections (e.g., BLA, IND amendments). Develop and execute strategies for process performance qualification (PPQ) and continued process verification (CPV). Collaborate cross-functionally with MSAT, Downstream, Analytical Development, CMC management, Manufacturing Operations, QA, QC, Regulatory, and Contract Manufacturers Represent upstream function in regulatory strategy, technical meetings, and CDMO interactions

Provide technical support for upstream process-related investigations, product impact assessments, change control assessments, CAPA assessments etc. Qualifications/Skills PhD in biology, biochemistry, chemical engineering or related scientific discipline with minimum 7 years of cell culture process development experience in the biotech/biopharma industry; or BS/MS with 12+ years of experience. In-depth understanding of CHO-based fed-batch processes, scale-up/scale-down principles, and statistical tools.

Thorough understanding of cell culture bioreactors including microbioreactors, bench-scale and pilot-scale bioreactors, and scaleup/tech transfer activities Demonstrated experience with late-stage upstream process development, PPQ strategy, tech transfer and BLA authoring Strong knowledge of regulatory expectations for process validation and control strategies. Excellent communication, leadership, and cross-functional collaboration skills. Demonstrated ability for taking initiative, creativity, and innovation in problem solving Experience working with novel large molecule formats such as bispecific antibodies and Fusion proteins/enzymes is a plus Demonstrated technical writing, critical thinking, scientific problem-solving and communication skills.

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About Cedent

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CEDENT strives to attract and retain the best people and provide an environment where they can all develop professionally and build a rewarding career. As a result, we create an inclusive environment that is rich in diversity, acknowledges each individual's uniqueness and promotes respect, personal achievement and stewardship. Our clients are global and so is CEDENT. We build and maintain a global workforce that includes people from different backgrounds, with a vast range of skills and experience all united by a common culture and commitment to help our clients achieve high performance. Cultivating a diverse workforce and inclusive work environment makes business sense. Our peoples varied skills are the talent engine that powers CEDENT, enabling it in turn to deliver the innovative solutions that help our clients outperform competitors.

Industry

It services

Company size

11 - 50 Employees

Headquarters location

Plano, TX, US

Year founded

2008

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