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Upstream Process Engineer Jobs (NOW HIRING)

Raya Workforce

Process Engineer

Lincoln, NE · On-site

Process Engineer - Biotech Location: Lincoln, NE Employment Type: Contract 1099| On-site Contract ... Drive improvements across upstream manufacturing and downstream packaging * Support line trials ...

Quality Agents, LLC

Process Engineer

Rockville, MD · On-site

The ideal candidate brings hands-on experience in biotech or pharmaceutical process engineering, with a focus on upstream, downstream or cell therapy operations. Key Responsibilities • Support the ...

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How much do upstream process engineer jobs pay per year?

As of May 31, 2026, the average yearly pay for upstream process engineer in the United States is $92,018.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,500.00 and $103,000.00 per year, depending on experience, location, and employer.

What does an Upstream Process Engineer do?

An Upstream Process Engineer is responsible for developing, optimizing, and scaling up processes related to the early stages of biopharmaceutical manufacturing, including cell culture and fermentation. They work on improving yield, ensuring process efficiency, and maintaining regulatory compliance. Their role involves troubleshooting, process design, and collaboration with cross-functional teams to support production.

What are the key skills and qualifications needed to thrive in the Upstream Process Engineer position, and why are they important?

Upstream Process Engineers require a solid background in chemical or biochemical engineering, process design, and troubleshooting, often backed by a relevant engineering degree. Familiarity with simulation software such as Aspen Plus or HYSYS, as well as knowledge of industry standards and certifications like Six Sigma or API, is highly valued. Strong communication, problem-solving abilities, and teamwork skills help these engineers excel when coordinating across multidisciplinary teams. These competencies are crucial to ensure process efficiency, safety, and innovation in large-scale production environments.

What are the typical daily responsibilities of an Upstream Process Engineer?

An Upstream Process Engineer typically focuses on designing, optimizing, and monitoring processes related to raw material extraction and initial conversion in industries such as oil & gas, biotechnology, or chemicals. Daily tasks might involve analyzing process data, troubleshooting equipment or process issues, implementing efficiency improvements, and ensuring compliance with safety and environmental regulations. Collaboration is a key part of the role, as you’ll work closely with operations, maintenance, quality assurance, and R&D teams to achieve production targets. Engineers also regularly participate in safety meetings, process audits, and project planning sessions to support continuous improvement. This dynamic environment offers exposure to both hands-on technical work and cross-functional project leadership.
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Upstream Process Engineer jobs near you

Process Engineer

Raya Workforce

Lincoln, NE • On-site

Full-time

Posted 13 days ago

Job description

Job Title: Process Engineer – Biotech
Location: Lincoln, NE
Employment Type: Contract 1099| On-site
Contract Length: 6 months – likely to extend
Work Authorization Requirement: U.S. Citizens or Green Card holders only
 
We’re hiring a hands-on Process Engineer to support both manufacturing & packaging in a regulated Biotech environment. This is a floor-focused, operator-facing role—not a desk-based position.
 
What you’ll do:
  • Troubleshoot process & equipment issues directly on the production floor
  • Work closely with operators, QA, QC, and engineering teams
  • Support deviations, root cause analysis (RCA), validation & change control
  • Drive improvements across upstream manufacturing and downstream packaging
  • Support line trials, startup activities, and project engineering (FAT/SAT)
What we’re looking for:
  • 7–10+ years in FDA/regulated manufacturing
  • Strong Biotech process experience (bioreactors, fill/finish, etc.)
  • Proven hands-on troubleshooting in live production environments
  • Experience supporting both manufacturing and packaging operations