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Senior Computational Designer Jobs (NOW HIRING)

Iambic Therapeutics, Inc

$124K - $172K/yr

... designs * Partner with ML scientists to integrate SBDD methods with our proprietary transformer ... Translate scientific questions into computational workflows and deliver actionable results

Precede Biosciences, Inc.

$110 - $150/hr

... senior computational team members, contributing to study execution against pre-defined protocols * Pursue defined research questions semi-independently - taking a scoped problem, designing the ...

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How much do senior computational designer jobs pay per year?

As of Sep 2, 2026, the average yearly pay for senior computational designer in the United States is $105,882.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $109,000.00 per year, depending on experience, location, and employer.

What is a senior computational designer?

A Senior Computational Designer is a professional who uses advanced computational tools, algorithms, and programming to solve design challenges, often in fields like architecture, engineering, or product design. They create digital models, automate design processes, and develop custom software solutions to enhance creativity and efficiency. In addition to technical proficiency, they often lead projects, mentor junior designers, and collaborate closely with multidisciplinary teams. Their work helps organizations push the boundaries of design innovation and optimize workflows.

What are the key skills and qualifications needed to thrive as a senior computational designer?

To thrive as a Senior Computational Designer, you need advanced proficiency in computational design principles, parametric modeling, and a relevant degree in architecture, engineering, or design. Expertise with tools like Rhino, Grasshopper, Python scripting, and BIM software, along with certifications in these platforms, is highly valued. Strong problem-solving abilities, creativity, and effective collaboration skills set exceptional candidates apart. These competencies are crucial for delivering innovative, efficient solutions and leading multidisciplinary teams in complex design projects.

What are some common challenges faced by senior computational designers when integrating new digital tools into existing design workflows?

Senior Computational Designers often encounter challenges when integrating new digital tools, such as ensuring compatibility with legacy software, training team members with varying skill levels, and maintaining design quality and consistency throughout the transition. Additionally, balancing creativity with technical constraints can require strong communication and collaboration with both designers and engineers. Proactively addressing these challenges by fostering open dialogue, providing training, and piloting tools before full implementation can help ensure a smooth workflow integration.

What is the difference between Senior Computational Designer vs Computational Designer?

AspectSenior Computational DesignerComputational Designer
CredentialsBachelor's or Master's in Architecture, Design, or related field; experience in computational toolsBachelor's or Master's in Architecture, Design, or related field; entry to mid-level experience
Work EnvironmentDesign firms, architecture studios, engineering companiesDesign firms, architecture studios, engineering companies
ResponsibilitiesLeading complex computational projects, mentoring juniors, advanced scriptingSupporting design processes with computational tools, developing scripts

While both roles involve computational design skills, Senior Computational Designers typically handle more complex projects, lead teams, and have more experience. Computational Designers focus on supporting design tasks and developing scripts under supervision. The senior role requires greater expertise and leadership, but both work within similar environments and industries.

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Senior Computational Designer jobs near you
Infographic showing various Senior Computational Designer job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, 6% Part Time, 1% Temporary, and 4% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $105,882 per year, or $50.9 per hour.

Research Scientist II/Senior, Computational Chemistry

Iambic Therapeutics, Inc

On-site, Remote

$124K - $172K/yr

Full-time

Medical, Life, Retirement, PTO

Posted 18 days ago

Job description

JOB SUMMARY
We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at Iambic Therapeutics. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, experience with or strong interest in applying modern co-folding approaches, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role will involve engagement in external partnerships.
This position will be based in our San Diego Headquarters, with exceptions for outstanding candidates to work remotely.
KEY RESPONSIBILITIES
  • Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD simulation)
  • Guide design cycles through the identification of structure-activity relationships and the integration of computational predictions with bioactivity data
  • Partner with medicinal chemists to design, evaluate and prioritize virtual libraries, and propose actionable molecular designs
  • Partner with ML scientists to integrate SBDD methods with our proprietary transformer-based property prediction technology (Enchant)
  • Leverage and evolve our proprietary protein-ligand co-folding technology (NeuralPLexer) to yield novel and actionable structural hypotheses
  • Translate scientific questions into computational workflows and deliver actionable results
  • Present results to internal project teams and external partners, explaining methods, implications and recommendations
  • Develop, validate, and maintain computational workflows and tools

QUALIFICATIONS
Required:
  • PhD or equivalent degree in computational chemistry (or related field) with 2+ years of relevant experience in drug discovery
  • Experience supporting active small molecule drug discovery programs
  • Experience with ligand and structure based design tools
  • Proficiency in Python for scientific computing, data analysis, and computational workflow development
  • Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.

Strongly preferred:
  • Industry experience supporting active drug discovery programs
  • Experience with molecular modeling platforms such as MOE, Schrödinger, OpenEye, or equivalent tools
  • Familiarity with MD simulation, molecular docking and advanced binding affinity prediction methods (e.g. MM/GBSA, FEP)
  • Experience with ML-augmented small molecule discovery

ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

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