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Remote Principal Scientist Jobs (NOW HIRING)

Jade Biosciences

Principal Scientist, Immunology

$175K - $190K/yr

The Principal Scientist will integrate literature, experimental data, and translational insights to ... This is a fully remote role, preferably based on the U.S. West Coast, with occasional domestic and ...

Oracle

[REMOTE] Principal Applied Scientist

As our Principal Applied Scientist, you will play a key role in shaping the future of AI at Oracle, with an emphasis on Large Language Models (LLMs) and Generative AI. Your contributions will be ...

Amgen

Senior Principal Scientist

Thousand Oaks, CA · On-site +1

Senior Principal Scientist What you will do Let's do this. Let's change the world! We are seeking ... The role is hybrid, option for remote work may be available What we expect of you We are all ...

Shasqi, Inc

Principal Scientist, ADME/PK

Position Overview We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead ... We are a remote-first company, with occasional travel for in-person team meetings or scientific ...

Crateandbarrel

Principal Data Scientist

This position is fully remote * This role is an Individual Contributor position A day in the life as a Principal Data Scientist... * Shapes the strategic direction for advanced analytics across the ...

Zillow

Principal Applied Scientist, Agentic AI

$181K - $290K/yr

... the role As a Principal Applied Scientist, you will set the science direction for advanced ... This role has been categorized as a Remote position. "Remote" employees do not have a permanent ...

Zillow

Principal Data Scientist - Rentals Shopping

$169K - $270K/yr

We are seeking a Principal Data Scientist to serve as the data science lead for the Rentals ... This role has been categorized as a Remote position. "Remote" employees do not have a permanent ...

Cimpress/Vista

What You Will Do As the Principal Data Scientist , you will drive the generative and context-aware ... We are an award winning Remote-First company. We're an inclusive community. We're growing (which ...

Zillow

Principal Applied Scientist, Agentic AI

$181K - $290K/yr

... the role As a Principal Applied Scientist, you will set the science direction for advanced ... This role has been categorized as a Remote position. "Remote" employees do not have a permanent ...

Zillow

Principal Applied Scientist, Agentic AI

$181K - $290K/yr

We collaborate closely with platform, product, and operations partners in a fast-moving, remote ... About the role As a Principal Applied Scientist focused on RL post-training, you will lead the ...

Zillow

Principal Applied Scientist, Agentic AI

$181K - $290K/yr

About the role As a Principal Applied Scientist focused on RL posttraining, you will lead the ... This role has been categorized as a Remote position. "Remote" employees do not have a permanent ...

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Remote Principal Scientist information

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$68.5K

$144K

$190.5K

How much do remote principal scientist jobs pay per year?

As of Aug 27, 2026, the average yearly pay for remote principal scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What does a remote principal scientist do?

A Remote Principal Scientist leads scientific research and development projects from a remote location, often overseeing teams, designing experiments, analyzing data, and providing expert guidance. They are responsible for setting research goals, ensuring scientific integrity, and contributing to strategic decisions in their field. Working remotely, they use digital tools to collaborate with colleagues, present findings, and manage project timelines. Their expertise often influences company policies, product development, or scientific direction.

What are the key skills and qualifications needed to thrive as a remote principal scientist?

To thrive as a Remote Principal Scientist, you need deep expertise in your scientific discipline, a PhD or equivalent experience, and a track record of leading successful research projects. Proficiency with advanced data analysis tools, laboratory information management systems (LIMS), and collaboration platforms is typically required. Strong leadership, communication, and self-motivation are essential soft skills, especially for managing remote teams and cross-functional projects. These skills ensure effective research direction, innovative problem-solving, and successful collaboration in a virtual scientific environment.

How does a remote principal scientist effectively collaborate with cross-functional teams while working offsite?

As a Remote Principal Scientist, effective collaboration often relies on leveraging digital communication tools and maintaining proactive engagement with cross-functional teams. Regular virtual meetings, clear documentation, and timely feedback are key to ensuring alignment on project goals and scientific direction. Building strong relationships with team members across research, regulatory, and product development functions helps streamline decision-making and problem-solving, even when working remotely. Adapting to different time zones and communication styles can be a common challenge, but flexibility and strong organizational skills are essential for maintaining productivity and team cohesion.

What is the difference between Remote Principal Scientist vs Remote Senior Scientist?

AspectRemote Principal ScientistRemote Senior Scientist
CredentialsAdvanced degree (PhD or equivalent), extensive research experienceMaster's or PhD, significant research background
Work EnvironmentLeads research projects, strategic planning, cross-functional collaborationConducts experiments, data analysis, supports project goals
Industry UsageUsed in biotech, pharma, and research-focused companiesCommon in similar industries, often as a senior technical role

The Remote Principal Scientist typically holds a higher level of responsibility, leading research initiatives and strategic decisions, whereas the Remote Senior Scientist focuses more on executing research tasks and supporting project development. Both roles require advanced scientific credentials and are prevalent in research-intensive industries, but the Principal Scientist has a broader leadership scope.

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Cities with the most Remote Principal Scientist job openings:

What are the most commonly searched types of Principal Scientist jobs?

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Remote Principal Scientist jobs near you
Infographic showing various Remote Principal Scientist job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, 9% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.

Principal Scientist, Immunology

Remote

Jade Biosciences
See more jobs at Jade Biosciencesexternal

$175K - $190K/yr

Full-time

Re-posted 3 days ago

Job description

Role Overview

The Research and Translational Medicine group at Jade is looking to add a Principal Scientist, Translational Research, to our team. This role will provide scientific leadership across immunology-driven research activities that support Jade's pipeline programs, including mechanism-of-action studies, disease biology assessment, indication evaluation, and translational strategy. The Principal Scientist will integrate literature, experimental data, and translational insights to strengthen program rationale, inform clinical development, and identify opportunities for pipeline expansion. This is an exciting opportunity to join a growing, highly collaborative biotech team and contribute to the advancement of potentially best-in-class therapies for autoimmune and inflammatory diseases.

This is a fully remote role, preferably based on the U.S. West Coast, with occasional domestic and international travel. The position reports to the Executive Director, Research and Translational Medicine.

Key Responsibilities 

  • Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights
  • Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs
  • Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy
  • Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions
  • Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities
  • Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility
  • Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation
  • Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications
  • Present findings to internal governance teams and external scientific forums
  • Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy

Qualifications 

  • PhD in Immunology or related field with 8-12+ years of relevant industry experience is required
  • Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms
  • Strong understanding of drug development, including how preclinical and translational data inform clinical strategy
  • Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus
  • Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical)
  • Strong written and verbal communication skills, with a track record of scientific publications and presentations
  • Ability to operate independently while contributing to a collaborative, fast-paced biotech environment

Position Location 

This is a remote role; periodic travel to team and company events is required. 

The anticipated salary range for candidates for this role is $175,000 - $190,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography. 

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