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Remote Principal Scientist Jobs (NOW HIRING)

Principal Software Engineer (Python)

Oxford, MS ยท On-site +1

$127K - $170K/yr

The hybrid-remote Principal Software Development Engineer leads the design, development, and ... Partner with the Data Science team to architect intelligent routing logic that leverages Small ...

Showing results 41-60

Remote Principal Scientist information

See salary details

$68.5K

$144K

$190.5K

How much do remote principal scientist jobs pay per year?

As of Aug 6, 2026, the average yearly pay for remote principal scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What is the difference between Remote Principal Scientist vs Remote Senior Scientist?

AspectRemote Principal ScientistRemote Senior Scientist
CredentialsAdvanced degree (PhD or equivalent), extensive research experienceMaster's or PhD, significant research background
Work EnvironmentLeads research projects, strategic planning, cross-functional collaborationConducts experiments, data analysis, supports project goals
Industry UsageUsed in biotech, pharma, and research-focused companiesCommon in similar industries, often as a senior technical role

The Remote Principal Scientist typically holds a higher level of responsibility, leading research initiatives and strategic decisions, whereas the Remote Senior Scientist focuses more on executing research tasks and supporting project development. Both roles require advanced scientific credentials and are prevalent in research-intensive industries, but the Principal Scientist has a broader leadership scope.

What does a remote principal scientist do?

A Remote Principal Scientist leads scientific research and development projects from a remote location, often overseeing teams, designing experiments, analyzing data, and providing expert guidance. They are responsible for setting research goals, ensuring scientific integrity, and contributing to strategic decisions in their field. Working remotely, they use digital tools to collaborate with colleagues, present findings, and manage project timelines. Their expertise often influences company policies, product development, or scientific direction.

How does a remote principal scientist effectively collaborate with cross-functional teams while working offsite?

As a Remote Principal Scientist, effective collaboration often relies on leveraging digital communication tools and maintaining proactive engagement with cross-functional teams. Regular virtual meetings, clear documentation, and timely feedback are key to ensuring alignment on project goals and scientific direction. Building strong relationships with team members across research, regulatory, and product development functions helps streamline decision-making and problem-solving, even when working remotely. Adapting to different time zones and communication styles can be a common challenge, but flexibility and strong organizational skills are essential for maintaining productivity and team cohesion.

What are the key skills and qualifications needed to thrive as a remote principal scientist?

To thrive as a Remote Principal Scientist, you need deep expertise in your scientific discipline, a PhD or equivalent experience, and a track record of leading successful research projects. Proficiency with advanced data analysis tools, laboratory information management systems (LIMS), and collaboration platforms is typically required. Strong leadership, communication, and self-motivation are essential soft skills, especially for managing remote teams and cross-functional projects. These skills ensure effective research direction, innovative problem-solving, and successful collaboration in a virtual scientific environment.
More about Remote Principal Scientist jobs
What cities are hiring for Remote Principal Scientist jobs? Cities with the most Remote Principal Scientist job openings:
What are the most commonly searched types of Principal Scientist jobs? The most popular types of Principal Scientist jobs are:
What states have the most Remote Principal Scientist jobs? States with the most job openings for Remote Principal Scientist jobs include:
Infographic showing various Remote Principal Scientist job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, 9% Part Time, 1% Temporary, and 1% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.

Principal Machine Learning Engineer, Artificial Intelligence (AI) Required, Work From Home

Ginas Tech Jobs

San Francisco, CA โ€ข Remote

Full-time

Medical, Dental, Vision, PTO

Posted 28 days ago


Job description

Job Description

Principal Machine Learning Engineer, Artificial Intelligence (AI) Required, Work From Home

As a Principal Machine Learning Engineer, you are a deep technical authority responsible for designing and evolving the most critical ML systems in the company.ย  The Principal Machine Learning Engineer will operate across training, inference, evaluation, and infrastructure, solving the hardest architectural and performance problems.ย  While Technical Leads may own execution at the team level, you set the technical standard and shape how ML systems are built across the organization.ย  This is a hands-on, high-impact role focused on depth.ย  This position is 100% Remote.

Principal Machine Learning Engineer Responsibilities:

- Architect and build large-scale ML systems spanning data, training, evaluation, inference, and deployment.

- Design reproducible, high-performance training pipelines across GPU infrastructure.

- Architect inference systems that balance latency, throughput, cost, and reliability at scale.

- Design and maintain data systems for high-quality synthetic and real-world training data.

- Implement evaluation pipelines covering performance, robustness, safety, and bias, in partnership with research leadership.

- Own production deployment, including GPU optimization, memory efficiency, latency reduction, and scaling policies.

- Collaborate closely with application engineering to integrate ML systems cleanly into backend, mobile, and desktop products.

- Make pragmatic trade-offs and ship improvements quickly, learning from real usage.

- Work under real production constraints: latency, cost, reliability, and safety

Principal Machine Learning Engineer Outcomes:

- ML systems (training, inference, evaluation) are reliable, scalable, and meet defined performance targets.

- Models deployed to production achieve measurable quality improvements and meet user-impact goals.

- Production issues are proactively monitored, debugged, and resolved with clear root-cause analysis.

- Team and cross-functional collaborators benefit from clear guidance, best practices, and scalable ML solutions.

- Research-to-production cycles are efficient, safe, and continuously improve the product experience.

Qualifications

Principal Machine Learning Engineer Qualifications:

- Strong background in deep learning and transformer-based architectures.

- Artificial Intelligence (AI) experience required.

- Hands-on experience training, fine-tuning, or deploying large-scale ML models in production.

- Proficiency with at least one modern ML framework (e.g. PyTorch, JAX), and ability to learn others quickly.

- Experience with distributed training and inference frameworks (e.g. DeepSpeed, FSDP, Megatron, ZeRO, Ray).

- Strong software engineering fundamentals; you write robust, maintainable, production-grade systems.

- Experience with GPU optimization, including memory efficiency, quantization, and mixed precision.

- Comfort owning ambiguous, zero-to-one ML systems end-to-end.

- A bias toward shipping, learning fast, and improving systems through iteration.

- Experience with LLM inference frameworks such as vLLM, TensorRT-LLM, or FasterTransformer.

- Contributions to open-source ML or systems libraries.

- Background in scientific computing, compilers, or GPU kernels.

- Experience with RLHF pipelines (PPO, DPO, ORPO).

- Experience training or deploying multimodal or diffusion models.

- Experience with large-scale data processing (Apache Arrow, Spark, Ray).

Benefits include medical insurance, Dental, Vision, Savings Plan Options, PTO, etc.

Keywords:ย  San Francisco CA Jobs, Principal Machine Learning Engineer, Apache Arrow, DeepSpeed, DPO, FasterTransformer, FSDP, GPU Kernels, JAX, LLM, Machine Learning, Megatron, ML, ORPO, PPO, Principal Machine Learning Engineer, Pytorch, RLHF Pipelines, Spark, TensorRT-LLM, Virtual Large Language Model, vLLM, Work From Home, ZeRO Ray, California Recruiters, IT Jobs, California Recruiting

Looking to hire a Principal Machine Learning Engineer in San Francisco, CA or in other cities?ย  Our IT recruiting agencies and staffing companies can help.

We help companies that are looking to hire Principal Machine Learning Engineers for jobs in San Francisco, California and in other cities too.ย  Please contact our IT recruiting agencies and IT staffing companies today!

Additional Information

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