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Principal Scientist Jobs (NOW HIRING)

Biotech Partners

Principal Scientist

Atlanta, GA · On-site

Principal Scientist - Immunoassay Development Location: Greater Atlanta Area (Hybrid/Onsite) We are seeking a Principal Scientist with expertise in immunoassay development and transfusion diagnostics ...

Kerr Dental

Principal Scientist

Pomona, CA

$156K - $190K/yr

Principal Scientist The Principal Scientist serves as a subject matter expert and technical leader, driving innovation and high-impact research and development initiatives across dental chemical ...

Dormont Manufacturing Co

WI · Hybrid

Legend Biotech is seeking a Sr. Principal/Principal Scientist as part of the Research & Early Development team based in Somerset, NJ . Role Overview Legend Biotech is seeking a highly experienced ...

Biotech Partners

Principal Scientist

Atlanta, GA · Hybrid

Greater Atlanta Area (Hybrid/Onsite) We are seeking a Principal Scientist with expertise in immunoassay development and transfusion diagnostics to support the development of innovative in vitro ...

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Principal Scientist information

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$68.5K

$144K

$190.5K

How much do principal scientist jobs pay per year?

As of Jul 14, 2026, the average yearly pay for principal scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What jobs pay 500,000 a year in the US?

Principal Scientists in high-demand industries such as pharmaceuticals, biotechnology, and technology can earn salaries approaching or exceeding $500,000 annually, especially with extensive experience, advanced degrees, and leadership roles. Compensation often includes base salary, bonuses, stock options, and other incentives, particularly in large corporations or startups with significant growth potential.

What Is a Principal Scientist?

A principal scientist takes the lead in research and development on a project. Staff researchers turn to the principal scientist for guidance and direction. As a principal scientist, your job duties include developing the research strategies to be used on the project, directing the research of staff scientists assigned to the project, and monitoring the progress of the study. The principal scientist may also be required to report progress to management and the funding organization.

How much does a principal scientist earn?

A principal scientist typically earns between $100,000 and $160,000 annually, depending on experience, industry, and location. They often hold advanced degrees and have extensive expertise in their field, which can influence salary levels.

What is the difference between Principal Scientist vs Senior Scientist?

AspectPrincipal ScientistSenior Scientist
Required CredentialsAdvanced degrees (PhD or equivalent), extensive research experienceMaster's or PhD, significant research background
Work EnvironmentLeads research projects, strategic planning, cross-functional collaborationConducts experiments, data analysis, supports project goals
Employer & Industry UsageResearch institutions, biotech, pharma, tech companiesResearch labs, R&D departments in similar industries

The main difference between a Principal Scientist and a Senior Scientist lies in their level of responsibility and scope. Principal Scientists typically lead research initiatives, set strategic directions, and have more experience, while Senior Scientists focus on executing research tasks and supporting project objectives. Both roles require advanced degrees and research expertise, but Principal Scientists hold a higher leadership and strategic role within organizations.

What does a principal scientist do?

A principal scientist leads research projects, develops scientific strategies, and oversees experimental work within their field. They analyze data, publish findings, and collaborate with teams to advance scientific knowledge or product development, often requiring advanced degrees and expertise in their area. They may also mentor junior staff and ensure compliance with industry standards and regulations.

What are Principal Scientists?

Principal Scientists are senior-level research professionals who lead scientific projects and teams within organizations such as research institutes, pharmaceutical companies, or technology firms. They are responsible for designing experiments, overseeing research operations, mentoring junior scientists, and ensuring the quality and innovation of scientific output. Principal Scientists often serve as subject matter experts and play a key role in strategic decision-making, grant writing, and publishing research findings. Their work significantly influences the direction and success of scientific initiatives.

What is the salary of a principal scientist in the US?

The average salary of a principal scientist in the US typically ranges from $110,000 to $160,000 per year, depending on industry, experience, and location. Senior roles with advanced expertise and leadership responsibilities may earn higher compensation, often supplemented with bonuses and benefits.

What are the key skills and qualifications needed to thrive as a Principal Scientist, and why are they important?

To thrive as a Principal Scientist, you need advanced expertise in your scientific discipline, a doctoral degree (PhD or equivalent), and a solid track record of research accomplishments. Familiarity with specialized laboratory equipment, data analysis software, and compliance with regulatory standards is typically required. Strong leadership, project management, and communication skills are essential for mentoring teams and collaborating across departments. These competencies enable Principal Scientists to drive innovation, ensure scientific rigor, and deliver impactful research outcomes.

How does a Principal Scientist typically collaborate with cross-functional teams in a research organization?

Principal Scientists often serve as key liaisons between research, development, and business units. They lead project teams, facilitate knowledge sharing, and ensure scientific strategies align with organizational goals. Collaboration may involve guiding junior scientists, working with regulatory affairs, and coordinating with manufacturing or quality assurance departments to translate research findings into practical applications. Effective communication and leadership skills are essential, as Principal Scientists must synthesize diverse perspectives to drive projects forward.
More about Principal Scientist jobs
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Principal Scientist jobs near you
Infographic showing various Principal Scientist job openings in the United States as of July 2026, with employment types broken down into 89% Full Time, 9% Part Time, 1% Temporary, and 1% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.
Principal Scientist

Principal Scientist

Global Channel Management, Inc.

Marlborough, MA

$95/hr

Contractor

Posted 5 days ago

Job description

Company Description

Global Channel Management is a technology company that specializes in various types of recruiting and staff augmentation.  Our account managers and recruiters have over a decade of experience in various verticals. GCM understands the challenges companies face when it comes to the skills and experience needed to fill the void of the day to day function.  Organizations need to reduce training and labor costs but at same requiring the best "talent " for the job. 


Qualifications

Principal Scientist needs Minimum of 4-6 years in a pharmaceutical
organization or related industry with a minimum of 2-3 years
pharmaceutical experience in a clinical safety or regulatory affairs


Principal Scientist requires:


Master Degree or PhD in Medical Science, Pharmacy or Nursing preferred.

  • Minimum
    of 2-3 years of medical writing experience (Prefer experience in
    writing pharmaceutical reports such as PSURs, Clinical Study Reports,
    safety sections of the ISS and/or Common Technical Document, or white
    paper) and/or experience in Medical Surveillance and Risk Management.
  • Proven understanding of clinical disease state and implications of treatment.
  • At ease with data and statistics.
  • Knowledge
    of ICH, US & EU regulations and requirements for pharmacovigilance
    (experience with world-wide safety reporting regulations and guidelines)
    and Risk Management.

Required

  • CLINICAL SAFETY
  • CLINICAL STUDY
  • CLINICAL TRIAL
  • PHARMACOVIGILANCE
  • CLINICAL TRIALS


Principal Scientist duties:


  • Work with others to determine topics for discussion in Section 9; prepare first draft of Section 9 for Medical Director review
  • Follow-up on issues identified in regulatory responses (e.g., assessment reports)
Additional Information

$95/hr

12 MONTHS

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About Global Channel Management

Sourced by ZipRecruiter

Global Channel Management is a technology company that specializes in various types of recruiting and staff augmentation. Global Channel Management understands the challenges companies face when it comes to the skills and experience needed to fill the void of the day to day function. Organizations need to reduce training and labor costs but at the same time requiring the best talent for the job. GCM's Ownership and Management teams have extensive Staffing, Recruiting, HR and Executive Leadership knowledge, Experience and Expertise. Our Understanding and Commitment to our Client's Satisfaction are key reasons GCM has been successful in establishing long term relationships.

Industry

Recruiting and staffing services

Company size

11 - 50 Employees

Headquarters location

Austell, GA, US

Year founded

2009

Social media

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