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Principal Toxicologist Jobs (NOW HIRING)

Frontage Laboratories

Principal Scientist

Exton, PA · On-site

... safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug ... Principal Scientist to join our In Vitro ADME group. This is a laboratory-based position ...

Merck & Co.

$142K - $224K/yr

- The Nonclinical Drug Safety department is seeking a - motivated and talented - toxicologist - to conduct and/or monitor toxicity studies (GLP and non-GLP) as a Study Director or Study Monitor. • ...

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$182K

How much do principal toxicologist jobs pay per year?

As of Sep 2, 2026, the average yearly pay for principal toxicologist in the United States is $109,393.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,000.00 and $125,000.00 per year, depending on experience, location, and employer.

What is a principal toxicologist?

A Principal Toxicologist is a senior-level expert who evaluates the safety and potential risks of chemicals, pharmaceuticals, or consumer products on human health and the environment. They design and oversee toxicological studies, interpret data, and ensure regulatory compliance with agencies like the FDA, EPA, or OSHA. Their role often includes guiding risk assessments, advising on product development, and mentoring junior toxicologists.

What are the typical responsibilities of a principal toxicologist?

As a Principal Toxicologist, your day-to-day responsibilities often include designing and overseeing toxicological studies, interpreting complex data, and preparing reports for regulatory submissions. You will frequently interact with multidisciplinary teams such as regulatory affairs, product development, and quality assurance to provide expert guidance on safety and compliance. In many organizations, you may also mentor junior scientists, review study protocols, and stay updated on evolving guidelines and scientific literature. This multi-faceted role offers a balance of hands-on scientific work, leadership, and cross-departmental collaboration.

What are the key skills and qualifications needed to thrive as a principal toxicologist?

A Principal Toxicologist requires advanced expertise in toxicology, pharmacology, and risk assessment, usually supported by a Ph.D. or equivalent experience in a relevant scientific field. Familiarity with regulatory guidelines (such as EPA, FDA, or REACH), laboratory information management systems (LIMS), and data analysis software is essential, as is certification through organizations like DABT when applicable. Strong leadership, strategic thinking, and effective communication skills help drive project teams and provide clear guidance to cross-functional stakeholders. These competencies ensure the Principal Toxicologist can lead complex studies, maintain regulatory compliance, and inform critical decision-making processes.

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Principal Toxicologist jobs near you
Infographic showing various Principal Toxicologist job openings in the United States as of August 2026, with employment types broken down into 90% Full Time, 8% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $109,393 per year, or $52.6 per hour.

Principal Environmental Professional

GSI Environmental Inc.

Houston, TX • On-site

Full-time

Re-posted 11 hours ago

Job description

GSI is a privately held, employee-owned company offering superior compensation, benefits, professional development, with ownership opportunities for excellent candidates. GSI is highly respected nationally and internationally for the quality of its professional environmental services and the technically advanced projects it has completed over its 39 years of operation.
GSI employs cross-disciplinary teams of environmental engineers and scientists, including toxicologists, geologists, hydrogeologists, ecologists, chemists, oceanographers, and data scientists with seamless collaboration over both technical disciplines and offices. Headquartered in Houston, Texas, GSI operates offices in Texas (Austin and Houston), California (Irvine, the San Francisco Bay Area, and Folsom), Colorado (Lakewood), Washington (Olympia), Montana (Missoula and Helena), North Carolina (Raleigh), and New York (Syracuse). Our talented staff of environmental professionals perform projects nationwide and internationally. Key opportunities of the Principal role will include:
  • Join a Thriving Firm: Be part of a privately-owned company renowned for its technical excellence and strong industry reputation. We are committed to measured, purposeful growth that maintains the integrity of our unique culture.
  • Be a Leader and Owner: Take on a significant role in managing a mid-sized company with over 250 employees. Enjoy meaningful ownership and profit-sharing opportunities that recognize and reward your contributions.
  • Advance the Science: Lead and innovate in the fields of toxicology, health sciences, and risk assessment. Your expertise will drive advancements and make a tangible impact on our projects and the industry.

Responsibilities:
The successful candidate will be responsible for leading a practice area that is complementary to GSIs existing technical service offerings. Preferred environmental disciplines include (but are not limited to) engineering, hydrogeology, toxicology, water resources, groundwater modeling, air quality, risk assessment, and compliance. The candidate will be responsible for the professional, technical, and administrative activities of the company. Develop long-range plans; provide effective leadership; and develop and recommend corporate objectives, goals, and budgets. Negotiate critical and controversial issues with officers of other organizations and companies. Take responsibility for a large segment of the company in area of specialization. Directly supervises technical staff and plays major role in maintaining staff utilization.
We support this role through our Houston and Austin, Texas offices and are open to engaging highly qualified candidates based in these markets, as well as in Dallas and San Antonio, Texas.
The successful candidate will have a strong track record of leadership and business development with the following qualifications:
  • Advanced degree in geosciences, engineering, toxicology, or related field.
  • 15-20 years of work experience with heavy emphasis on environmental consulting for the private sector.
  • Professional licensure, such as Professional Engineer (PE), Professional Geoscientist (PG), Diplomate American Board of Toxicology (DABT) certification.
  • Direct experience with groundwater/soil/air contamination, contaminant fate and transport, and site investigation/remediation.
  • Litigation experience as a consulting and/or testifying expert.
  • Experience serving as a primary point of contact with clients and managing project teams and budgets.
  • Experience developing sampling plans for remedial investigations, constructing conceptual models, conducting data analysis and visualization, and preparing technical reports.
  • Ability to perform independent research and analysis.
  • Ability to work across geographies with experts in different offices.
  • Strong mentoring, professional development of staff, and recruiting skills.
  • Excellent verbal and written communication skills.
  • Working knowledge of state and federal environmental cleanup regulations is preferred (e.g., TRRP, LPST Rules, and/or Railroad Commission of Texas Cleanup Rules, RCRA, and/or CERCLA).
  • 40-hour OSHA HAZWOPER certification preferred

Job Perks:
  • Competitive salary and benefits with attractive year-end bonuses.
  • Expectation for company share ownership.
  • Flexible work environment with potential for remote work.
  • Participation in conferences, technical presentations, and publications.
  • Collaborative atmosphere.

The base salary for this position will be determined by the candidate's geographic location, education, relevant degree, related experience, and overall qualifications.

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