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MSD

Senior Scientist, Pharmacokinetics

West Point, PA · On-site

$95.50K - $121.70K/yr

Senior Research Scientist (R3) - Biotransformation & Metabolite Identification Location: West Point, Pennsylvania (On-site) Position Overview: The DMPK group at our company's Research Laboratories is ...

Merck & Co.

The ideal candidate has deep expertise in drug metabolism, including biotransformation mechanisms, in vitro and in vivo tools, and state of the art instrumentation used in support of metabolite ...

Merck & Co.

$95.50K - $121.70K/yr

Senior Research Scientist (R3) - Biotransformation & Metabolite IdentificationLocation: West Point, Pennsylvania (On-site)Position Overview:The DMPK group at our company's Research Laboratories is ...

MSD

Director, Pharmacokinetics

West Point, PA

The Biotransformation Lead (Director) will play a pivotal role in guiding our company's discovery and development projects through the lens of drug metabolism, ensuring that metabolite profiles are ...

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How much do biotransformation jobs pay per hour?

As of May 30, 2026, the average hourly pay for biotransformation in the United States is $30.99, according to ZipRecruiter salary data. Most workers in this role earn between $24.04 and $35.58 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Biotransformation Scientist, and why are they important?

To thrive as a Biotransformation Scientist, you need a strong background in biochemistry, pharmacology, and analytical chemistry, typically supported by an advanced degree (M.S. or Ph.D.) in a related field. Familiarity with analytical tools such as LC-MS/MS, in vitro/in vivo assay systems, and specialized data analysis software is essential. Strong problem-solving skills, attention to detail, and effective communication are crucial soft skills for interpreting complex data and collaborating with multidisciplinary teams. These skills ensure accurate drug metabolism profiling, regulatory compliance, and the advancement of pharmaceutical research.

What are some typical challenges faced by professionals working in biotransformation, and how can they be addressed?

Professionals in biotransformation often encounter challenges such as interpreting complex metabolic pathways, working with limited experimental data, and keeping up with evolving analytical technologies. Overcoming these challenges requires strong problem-solving skills, continuous learning, and effective collaboration with multidisciplinary teams including chemists, toxicologists, and computational biologists. Regularly participating in training sessions and scientific conferences can also help biotransformation scientists stay current with industry trends and best practices.

What is biotransformation?

Biotransformation refers to the chemical modification of compounds, such as drugs or pollutants, by living organisms or their enzymes. This process is essential in fields like pharmacology, where it helps determine how the body metabolizes medications, and in environmental science, where it aids in breaking down environmental contaminants. Biotransformation can involve processes like oxidation, reduction, and hydrolysis, leading to the detoxification or activation of substances. Professionals in this field study these pathways to improve drug development, waste treatment, and understanding of biological systems.

What is the difference between Biotransformation vs Pharmacologist?

AspectBiotransformationPharmacologist
Required CredentialsBachelor's or Master's in Chemistry, Biochemistry, or related fieldsDoctorate (PhD) in Pharmacology or related discipline
Work EnvironmentLaboratories, pharmaceutical companies, research institutionsResearch labs, academia, pharmaceutical industry
Industry UsageDrug metabolism, environmental science, biotechnologyDrug development, clinical research, toxicology

Biotransformation involves the chemical modification of substances within the body, primarily focusing on drug metabolism processes. Pharmacologists study the effects, mechanisms, and interactions of drugs, often including biotransformation as part of their research. While biotransformation specialists focus on how substances are processed, pharmacologists have a broader scope, encompassing drug action and therapeutic effects.

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Biotransformation jobs near you
Senior Scientist/Principal Scientist- Biotransformation/Met ID

Senior Scientist/Principal Scientist- Biotransformation/Met ID

Frontage Laboratories

Exton, PA • On-site

Full-time

Posted 20 days ago

Job description

Job Title: Senior Scientist / Principal Scientist – Biotransformation/Metabolite Identification.

Location: Exton, Pennsylvania

Full-time

Job Description:
We are seeking a highly motivated and experienced Senior Scientist specializing in Biotransformation and Metabolite Identification to join our dynamic team. This individual will play a pivotal role in the characterization and identification of drug metabolites, contributing to our understanding of drug metabolism and its impact on drug safety and efficacy.

Key Responsibilities:

  • Design, execute, and interpret biotransformation studies to characterize drug metabolites in vitro and in vivo.
  • Develop and optimize sample preparation and analytical techniques for metabolite profiling and identification using state-of-the-art LC-MS/MS and high-resolution mass spectrometry (HRMS).
  • Interact with clients to provide actionable insights on metabolism-related challenges.
  • Prepare and review scientific reports, presentations, and regulatory documents to ensure accuracy and compliance with industry standards.
  • Stay updated on advancements in biotransformation and metabolite identification technologies and methodologies.

Qualifications:

  • Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
  • Strong expertise in drug metabolism and biotransformation, with hands-on experience in metabolite identification using LC-MS/MS and HRMS.
  • Knowledge of in vitro (e.g., hepatocytes, microsomes) and in vivo systems for studying drug metabolism.
  • Familiarity with regulatory guidelines (e.g., FDA, EMA) for metabolite safety testing (MIST).
  • Demonstrated ability to analyze and interpret complex mass spectrometry data and provide detailed reports.
  • Excellent communication skills and ability to work collaboratively in a cross-functional team environment.

Preferred Skills:

  • Experience with radiolabeled compounds and metabolite profiling.
  • Track record of publications or presentations in the field of drug metabolism or biotransformation.
  • Hand-on experience on Thermo OrbiTrap or Waters Q-TOF.

What We Offer:

  • Competitive salary and benefits package.
  • Opportunities for professional growth and development.
  • A collaborative and innovative work environment.

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability