Biotransformation Jobs (NOW HIRING)

Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.

Position 

Nurix Therapeutics is searching for a motivated Research Associate II to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments.  The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

Responsibilities

• Provide bioanalytical support for in-house PK, non-GLP safety TK
• Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
• Conduct in-vitro stability assays to understand metabolism of drugs
• Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment
• Independently operate, troubleshoot and maintain LC-MS/MS systems
• Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support
• Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines
• Maintain accurate and detailed scientific electronic laboratory notebooks
• Perform all duties in keeping with the Company's core values, policies and all applicable regulations

Preferred Qualifications & Experience

• Experience with H/UPLC and mass spectrometry
• Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation
• PK analysis using Phoenix or other data management software
• Management experience with CROs for outsourcing BA activities is preferred
• Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies
• Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports.
• Excellent oral and written communication skills

Minimum Requirements

• BS or master's with 4 years' experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company
• Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using LC-MS/MS
• Experience with AB SCIEX mass spectrometry software
• Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Location  Brisbane, CA - Onsite 

Salary Range    93K - 107K