1

Biotransformation Jobs (NOW HIRING)

Associate Principal Scientist

Indianapolis, IN · On-site +1

$80K - $167K/yr

The Associate Principal Scientist provides scientific leadership in in vitro and in vivo metabolism and biotransformation studies, with a primary focus on mass spectrometry data interpretation ...

We are seeking Senior Scientist - Biotransformation to join IQVIA Laboratories at Indianapolis, IN. We hire passionate innovators who drive healthcare forward through thoughtful and inclusive ...

Scientist

Hayward, CA · On-site

$80K - $110K/yr

Strong expertise in drug metabolism and biotransformation, with hands-on experience in metabolite identification using LC-MS/MS and HRMS. * Demonstrated ability to analyze and interpret complex mass ...

Demonstrated experience processing biological samples and quantifying biologics, small molecules, ADCs, payloads, and metabolites, including biotransformation assessments. * Proficiency in ...

Scientist, Biology

Foster City, CA · On-site

$146K - $189K/yr

Demonstrated experience processing biological samples and quantifying biologics, small molecules, ADCs, payloads, and metabolites, including biotransformation assessments. * Proficiency in ...

Scientist, Biology

Foster City, CA · On-site

$146K - $189K/yr

Demonstrated experience processing biological samples and quantifying biologics, small molecules, ADCs, payloads, and metabolites, including biotransformation assessments. * Proficiency in ...

Showing results 21-40

Biotransformation information

See salary details

$17

$30

$52

How much do biotransformation jobs pay per hour?

As of Aug 12, 2026, the average hourly pay for biotransformation in the United States is $30.99, according to ZipRecruiter salary data. Most workers in this role earn between $24.04 and $35.58 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a biotransformation scientist, and why are they important?

To thrive as a Biotransformation Scientist, you need a strong background in biochemistry, pharmacology, and analytical chemistry, typically supported by an advanced degree (M.S. or Ph.D.) in a related field. Familiarity with analytical tools such as LC-MS/MS, in vitro/in vivo assay systems, and specialized data analysis software is essential. Strong problem-solving skills, attention to detail, and effective communication are crucial soft skills for interpreting complex data and collaborating with multidisciplinary teams. These skills ensure accurate drug metabolism profiling, regulatory compliance, and the advancement of pharmaceutical research.

What is the difference between Biotransformation vs Pharmacologist?

AspectBiotransformationPharmacologist
Required CredentialsBachelor's or Master's in Chemistry, Biochemistry, or related fieldsDoctorate (PhD) in Pharmacology or related discipline
Work EnvironmentLaboratories, pharmaceutical companies, research institutionsResearch labs, academia, pharmaceutical industry
Industry UsageDrug metabolism, environmental science, biotechnologyDrug development, clinical research, toxicology

Biotransformation involves the chemical modification of substances within the body, primarily focusing on drug metabolism processes. Pharmacologists study the effects, mechanisms, and interactions of drugs, often including biotransformation as part of their research. While biotransformation specialists focus on how substances are processed, pharmacologists have a broader scope, encompassing drug action and therapeutic effects.

What is biotransformation?

Biotransformation refers to the chemical modification of compounds, such as drugs or pollutants, by living organisms or their enzymes. This process is essential in fields like pharmacology, where it helps determine how the body metabolizes medications, and in environmental science, where it aids in breaking down environmental contaminants. Biotransformation can involve processes like oxidation, reduction, and hydrolysis, leading to the detoxification or activation of substances. Professionals in this field study these pathways to improve drug development, waste treatment, and understanding of biological systems.

What are some typical challenges faced by professionals working in biotransformation, and how can they be addressed?

Professionals in biotransformation often encounter challenges such as interpreting complex metabolic pathways, working with limited experimental data, and keeping up with evolving analytical technologies. Overcoming these challenges requires strong problem-solving skills, continuous learning, and effective collaboration with multidisciplinary teams including chemists, toxicologists, and computational biologists. Regularly participating in training sessions and scientific conferences can also help biotransformation scientists stay current with industry trends and best practices.
More about Biotransformation jobs
What cities are hiring for Biotransformation jobs? Cities with the most Biotransformation job openings:
What states have the most Biotransformation jobs? States with the most job openings for Biotransformation jobs include:
What job categories do people searching Biotransformation jobs look for? The top searched job categories for Biotransformation jobs are:
Infographic showing various Biotransformation job openings in the United States as of August 2026, with employment types broken down into 93% Full Time, and 7% Contract. Highlights an 90% Physical, 5% Hybrid, and 5% Remote job distribution, with an average salary of $64,466 per year, or $31 per hour.

Sr Scientist/ Principal Investigator- Bioanalysis DMPK Biotransformation group

RPM ReSearch

Saint Louis, MO

$80K - $120K/yr

Full-time

Medical, Dental, Vision, Retirement

Re-posted 23 days ago


Job description

Job Description




Position Title

Senior Scientist/ Principal Investigator - Bioanalysis DMPK Biotransformation

We are looking for an accomplished scientist to join our growing drug discovery DMPK and Small Molecule Bioanalysis team. Our site has grown to 120 employees and our team has grown to 8 scientists. We have developed a collaborative culture and mutual respect. Our site is part of a 2400 person growing publicly traded international organization with over 15 sites. We recently made a $4.5MM investment in our site.


The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology, and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.



Position Requirements

Education and experience

  • BS or equivalent degree in Chemistry, Biochemistry, or related field, and greater than 15 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management or
  • MS in Chemistry, Biochemistry, or related field, and 7 to 10 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management or,
  • Ph.D. in Chemistry, Biochemistry, or related field and 3 to 5 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management


Skills and abilities


  • Working knowledge and awareness of general laboratory procedures.
  • Displays versatility and accuracy performing laboratory operations, some of which may be difficult and/or non-routine.
  • Ability to use a computer to compile and maintain databases for records and inventory, utilizing the appropriate software.
  • Ability to adhere to all safety regulations and procedures.
  • In-depth knowledge and specific understanding of analytical testing needed in drug discovery as it relates to DMPK.
  • Understanding of GMP/GLP/GCP regulations with the ability to apply these practices daily.
  • An attitude for quality, an eye for detail, the ability to follow written instructions and work with a minimum of supervision.
  • Strong Knowledge of LC-MS/MS instrumentation, troubleshooting, method development, and analysis of biological fluids and tissues, preferably on a Sciex Platform for qualitative and quantitative analysis




Responsibilities and Duties


  • Lead, train, and mentor colleagues to enhance analytical skills and DMPK knowledge.
  • Lead efforts to troubleshoot and solve method development or assay challenges.
  • Establish the experimental design and manage the conduct of studies in compliance with the protocol/amendments/planned changes, Best Practice Documents, and SOPs.
  • Perform all other duties and responsibilities of a Principal Investigator as defined in applicable SOPs
  • Operate analytical instrumentation and lab equipment and perform analyses according to the Operation Manuals, SOPs, and/or Best Practices.
  • Contribute to existing SOPs and develop new SOPs as needed.
  • Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations
  • Serve as the Company representative and point of contact to Study Directors and/or Sponsors for bioanalytical projects. This includes the establishment of a correspondence file for documenting Study Director/client exchanges including phone conversations, emails, faxes, and mail.
  • Provide a central internal and external scientific contact for studies within the Bioanalytical group. Represent the company by providing support for scientific posters or presentations at scientific meetings and/or client visits.
  • Perform method development, method qualification, and/or other study-related activities.
  • Determine and allocate resource needs for study execution.
  • Review literature to determine the most appropriate approach for project-specific bioanalytical needs.
  • Assure that the Lab Manager and/or Study Director is aware of any deviations from the study protocol and/or SOPs during a study and ensure that proper documentation is performed.
  • Review and approve raw data and reports to be sent to internal and external clients.
  • Assure that study data and samples are compiled, organized, inventoried, and archived at Company or transferred to the testing facility archive/client prior to or upon completion of the services, as applicable


Employees are offered a fun, fast-paced work environment with competitive pay, benefits package including medical, dental, and vision insurance, 401k with company match, stock options, and much more!