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Principal Toxicologist Jobs (NOW HIRING)

RPM ReSearch

$125K - $130K/yr

Principal Scientist / Study Director (Toxicology) Build Programs. Lead Science. Influence Outcomes. Why This Role Matters Here, toxicology isn't just about executing studies--it's about shaping how ...

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Precise Systems

In-Vitro Toxicologist

Aberdeen, MD · On-site

$76K - $86K/yr

Precise Systems seeks a In-Situ Toxicologist to support our U.S. Army customer in Edgewood ... Interacts as part of an interdisciplinary team of technical staff, and principal investigators.

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How much do principal toxicologist jobs pay per year?

As of Jul 1, 2026, the average yearly pay for principal toxicologist in the United States is $109,393.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,000.00 and $125,000.00 per year, depending on experience, location, and employer.

What is a Principal Toxicologist job?

A Principal Toxicologist is a senior-level expert who evaluates the safety and potential risks of chemicals, pharmaceuticals, or consumer products on human health and the environment. They design and oversee toxicological studies, interpret data, and ensure regulatory compliance with agencies like the FDA, EPA, or OSHA. Their role often includes guiding risk assessments, advising on product development, and mentoring junior toxicologists.

What are the key skills and qualifications needed to thrive in the Principal Toxicologist position, and why are they important?

A Principal Toxicologist requires advanced expertise in toxicology, pharmacology, and risk assessment, usually supported by a Ph.D. or equivalent experience in a relevant scientific field. Familiarity with regulatory guidelines (such as EPA, FDA, or REACH), laboratory information management systems (LIMS), and data analysis software is essential, as is certification through organizations like DABT when applicable. Strong leadership, strategic thinking, and effective communication skills help drive project teams and provide clear guidance to cross-functional stakeholders. These competencies ensure the Principal Toxicologist can lead complex studies, maintain regulatory compliance, and inform critical decision-making processes.

What are some typical responsibilities of a Principal Toxicologist on a day-to-day basis?

As a Principal Toxicologist, your day-to-day responsibilities often include designing and overseeing toxicological studies, interpreting complex data, and preparing reports for regulatory submissions. You will frequently interact with multidisciplinary teams such as regulatory affairs, product development, and quality assurance to provide expert guidance on safety and compliance. In many organizations, you may also mentor junior scientists, review study protocols, and stay updated on evolving guidelines and scientific literature. This multi-faceted role offers a balance of hands-on scientific work, leadership, and cross-departmental collaboration.

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Principal Toxicologist jobs near you

Sr. Principal Scientist Toxicologist

1 Legacy, Inc

Framingham, MA

Full-time

Posted 17 days ago

Job description

Company Description

Medical / Health - Pharmacy

Job Description

This position will provide Preclinical Safety a wide range of support associated with Toxicology and Safety Pharmacology needs on Discovery and Development Project Teams for Group projects.  This position would provide scientific expertise across the drug discovery and development value chain on biotherapeutics and small molecules.  Activities include, but are not limited to:
Serve as Preclinical Safety Project Team Representative on multi-disciplinary Discovery and Development teams responsible for the progression of both biotherapeutics and small molecule drug candidates for regulatory submissions.  These activities include designing and coordinating a multi-disciplinary effort to support such projects through the development of the nonclinical safety strategy and program which includes, but is not limited to attending various project team meetings; the design and interpretation of toxicity studies; the preparation and/or review of written preclinical safety reports; and the authoring of the nonclinical document sections for regulatory submissions.
Serve as internal biotherapeutics expert for scientific issues related to nonclinical safety issues related to the development of these molecules
Interact with multiple functions (Pharmacology, Regulatory Affairs, Clinical, Project Leaders & Managers, etc.) on a daily basis
Involved with the multiple Community of Practice groups in preclinical safety and provide input to address safety issues; including design and conduct of investigative studies in support of the toxicological evaluation of compounds
Participate in Preclinical Safety Department activities (staff meeting, scientific forums, etc.), and special projects
Participate in special projects or inter-industry working groups, as needed.  Provide scientific input on design and analysis of research activities
Ensure high scientific standards and adhering to requested timelines in all aspects of the position  

Qualifications

Basic Qualifications:
PhD or DVM and post-doctoral experience
Experience in development of biotherapeutics is required. 
6-8 years of relevant industry experience
Knowledgeable about GLP policies and/or regulatory nonclinical testing requirements for pharmaceutical development of biotherapeutics and small molecules
Preparation of regulatory documents for submission to health authorities

Additional Information

All your information will be kept confidential according to EEO guidelines.

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