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Principal Toxicologist Jobs (NOW HIRING)

RPM ReSearch

$125K - $130K/yr

Principal Scientist / Study Director (Toxicology) Build Programs. Lead Science. Influence Outcomes. Why This Role Matters Here, toxicology isn't just about executing studies--it's about shaping how ...

Boehringer Ingelheim GmbH

$200 - $250/hr

Senior Principal/ Principal Scientist, Computational Safety Description We are seeking a Senior ... This role will leverage advanced multi omics data, systems toxicology and AI/ML approaches to ...

Precise Systems

In-Vitro Toxicologist

Aberdeen, MD · On-site

$76K - $86K/yr

Precise Systems seeks a In-Situ Toxicologist to support our U.S. Army customer in Edgewood ... Interacts as part of an interdisciplinary team of technical staff, and principal investigators.

Amgen SA

Senior Principal Scientist

Thousand Oaks, CA · On-site

$200 - $250/hr

Senior Principal Scientist What you will do Let's do this. Let's change the world ... We are seeking an experienced toxicologist in the Product Stewardship group within our Environment ...

Amgen

Senior Principal Scientist

Thousand Oaks, CA · On-site +1

Senior Principal Scientist What you will do Let's do this. Let's change the world ... We are seeking an experienced toxicologist in the Product Stewardship group within our Environment ...

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How much do principal toxicologist jobs pay per year?

As of Sep 9, 2026, the average yearly pay for principal toxicologist in the United States is $109,393.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,000.00 and $125,000.00 per year, depending on experience, location, and employer.

What is a principal toxicologist?

A Principal Toxicologist is a senior-level expert who evaluates the safety and potential risks of chemicals, pharmaceuticals, or consumer products on human health and the environment. They design and oversee toxicological studies, interpret data, and ensure regulatory compliance with agencies like the FDA, EPA, or OSHA. Their role often includes guiding risk assessments, advising on product development, and mentoring junior toxicologists.

What are the typical responsibilities of a principal toxicologist?

As a Principal Toxicologist, your day-to-day responsibilities often include designing and overseeing toxicological studies, interpreting complex data, and preparing reports for regulatory submissions. You will frequently interact with multidisciplinary teams such as regulatory affairs, product development, and quality assurance to provide expert guidance on safety and compliance. In many organizations, you may also mentor junior scientists, review study protocols, and stay updated on evolving guidelines and scientific literature. This multi-faceted role offers a balance of hands-on scientific work, leadership, and cross-departmental collaboration.

What are the key skills and qualifications needed to thrive as a principal toxicologist?

A Principal Toxicologist requires advanced expertise in toxicology, pharmacology, and risk assessment, usually supported by a Ph.D. or equivalent experience in a relevant scientific field. Familiarity with regulatory guidelines (such as EPA, FDA, or REACH), laboratory information management systems (LIMS), and data analysis software is essential, as is certification through organizations like DABT when applicable. Strong leadership, strategic thinking, and effective communication skills help drive project teams and provide clear guidance to cross-functional stakeholders. These competencies ensure the Principal Toxicologist can lead complex studies, maintain regulatory compliance, and inform critical decision-making processes.

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Principal Toxicologist jobs near you
Infographic showing various Principal Toxicologist job openings in the United States as of September 2026, with employment types broken down into 90% Full Time, 8% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $109,393 per year, or $52.6 per hour.

Principal Scientist, Toxicology

Bridgewater, NJ • On-site

Ptc Therapeutics, Inc.
Manufacturing • 501 - 1,000 employees
Learn more about Ptc Therapeutics, Inc.external

$165K - $185K/yr

Full-time

Medical, Dental, Vision, Retirement

Re-posted 4 hours ago

Key responsibilities

  • Designs and oversees nonclinical safety studies to support the development program for candidate compounds.

  • Develops protocols, monitors studies, and reviews, revises, and issues reports required for the nonclinical program.

  • Prepares regulatory documents including Toxicology sections of briefing books, INDs, and investigator brochures.

Job description

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture!
Site: www.ptcbio.com

Job Description Summary: The Principal Scientist, Toxicology is responsible for the design and oversight of nonclinical safety studies of development candidates. The Principal Scientist works independently to plan, execute and interpret nonclinical safety studies. He/she will interact within the organization to communicate relevant safety information and act as a toxicology representative in interactions with Project teams, Collaborators, and Contract Research Organizations (CROs).
The incumbent works cross-functionally with internal departments and external resources on nonclinical safety-related issues.
The Principal Scientist, Toxicology has a thorough knowledge of and ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.Job Description:

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

  • Designs and oversees studies in support of the nonclinical development program for development candidate compounds.
  • Develops protocols and monitors studies, as well as reviews, revises, and issues reports required for the nonclinical program.
  • Writes/Prepares regulatory documents including Toxicology sections of briefing books, investigational new drug applications (INDs), and investigator brochures (IBs).
  • Acts as a toxicology representative in interactions with collaborators and contract research organizations.
  • Performs other tasks and assignments as needed and specified by management.

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

Minimum level of education and years of relevant work experience:

  • Ph.D. in Toxicology or other related discipline and a minimum of 7 years experience with progressively increasing responsibilities in a pharmaceutical, biotechnology or related environment.

Special knowledge or skills needed and/or licenses or certificates required:

  • Hands on experience with nonclinical safety studies.
  • Experience in the conduct of studies in compliance with Good Laboratory Practices (GLP).
  • Demonstrated and applied knowledge of US and international regulatory requirements for the conduct and design of nonclinical safety studies.
  • Demonstrated ability to write scientific documents and reports. These include, but may not be limited to, protocols, reports, and regulatory documents/submissions.
  • Proficiency with Microsoft Office.
  • Excellent verbal and written communication skills.
  • Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
  • Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.

Special knowledge or skills and/or licenses or certificates preferred:

  • Diplomate of the American Board of Toxicology (DABT)
  • Experience with orphan diseases.

Travel requirements:

  • 10-25%

Expected Base Salary Range

$165,000 - $185,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity.

In addition to base salary, PTC employees are also eligible for short- and long-term incentives.All eligible employees may also enroll in PTC's medical, dental, vision, and retirement savings plans.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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