Model Predictive Control Jobs in New York (NOW HIRING)

-We are proud of our over 125 years of service to humanity and continue to be one of the world's biggest investors in Research & Development.We are seeking a Senior Scientist to join our Digital Insights team within the Development Sciences and Clinical Supply (DSCS) Digital Technologies organization. Digital is the multiplier that will allow DSCS to deliver better experiments faster, efficient filing and launch, more robust supply chains and higher-confidence decisions across the portfolio.The DSCS Digital Technologies organization is responsible for the invention and application of new digital tools/workflows to support scientists across drug substance development, drug product development and analytical development. We aspire to embed digital technologies into the fabric of DSCS culture to drive transformational impact.

The tools that we develop are the teams developing them, and in this Senior Scientist role, the successful candidate will advance the company's digital-first process development strategy by deploying mechanistic, CFD(Computational Fluid Dynamics)-based, and data-driven modeling approaches to design, de-risk, and optimize sterile drug substance (DS) and drug product (DP) manufacturing processes. The position will sit at the intersection of first-principles physics, advanced CFD, and machine learning / data science, enabling predictive understanding, robust scale-up, and accelerated clinical-to-commercial delivery across biologics and vaccines.The successful candidate will play a technical leadership role in building and applying mixing and unit-operation virtual twins, integrating CFD with experimental data and AI/ML methods, and translating model outputs into actionable CMC and manufacturing decisions.- Responsibilities: Develop and deploy a portfolio of mechanistic, CFD, and data-driven models to support development, scale-up, tech transfer, and manufacturing of sterile DS and DP processes across a biologics and vaccine pipeline.Lead CFD-based mixing and unit operation modeling (e.g., compounding, dilution, pumping, filling, filtration) to quantify hydrodynamic stresses, energy dissipation rates, mixing times, and scale-up risk-enabling science-based operating windows and control strategies.Integrate data science and machine learning with physics-based models to accelerate model execution, improve predictive accuracy, and enable rapid scenario screening.Collaborate closely with stakeholders to de-risk sterile process scale-up, optimize formulation and process robustness, and support clinical-to-commercial transitions.Design, execute, and interpret scale-down and validation experiments to establish model credibility and scalability. Use experimental data to validate and refine CFD and ML models.Own end-to-end modeling project execution, including problem formulation, data requirements, simulation workflows, model validation, reporting, and clear communication of predictions and uncertainty to cross-functional stakeholders.Establish best practices for modeling workflows, including pre/post-processing, HPC and cloud computing utilization, data management, version control, and model reuse.

Contribute to standardized playbooks and a central model repository.Demonstrate excellent interpersonal, communication, and collaboration skills.Embrace and model our core values including fostering a supportive culture where all can thrive.Be able to effectively collaborate in a dynamic, integrated, and multidisciplinary team environment.Demonstrate a clear ability to perform impactful scientific innovation in a team-oriented manner that builds trusted partnerships across vast stakeholder networks.Education Minimum Requirement: Ph.D. in Computer Science, Data Science, Chemical Engineering, Mechanical Engineering, Chemistry, Physics, Biology, Pharmaceutical Sciences, or a closely-related field.MS in Computer Science, Data Science, Chemical Engineering, Mechanical Engineering, Chemistry, Physics, Biology, Pharmaceutical Sciences, or a closely-related field with at least 2 years of industrial/pharmaceutical or relevant experience.BS in Computer Science, Data Science, Chemical Engineering, Mechanical Engineering, Chemistry, Physics, Biology, Pharmaceutical Sciences, or a closely-related field with at least 4 years of industrial/pharmaceutical or relevant experience.Required Experience and Skills: Strong expertise in CFD and transport phenomena, with hands-on experience using tools such as ANSYS Fluent, STAR-CCM+, M-Star, COMSOL, OpenFOAM, or equivalent.Demonstrated experience with multiphase and complex flows, including free-surface modeling (VOF), turbulent flows, non-Newtonian rheology, and/or particle-laden systems.Strong programming and data science skills in Python, MATLAB, R, JMP, or equivalent, including data wrangling, visualization, model coupling, and workflow automation.Experience validating models against experimental data and designing representative scale-down systems.Ability to translate complex modeling results into clear, actionable insights for non-modeling audiences; strong written and verbal communication skills.Preferred Experience and Skills: Experience with sterile CMC development workflows, particularly unit operations such as mixing, pooling, pumping, filling, filtration, or freeze-drying.Applied understanding of QbD, DOE, and model validation frameworks, including statistical design and analysis of experiments.Working knowledge of multivariate data analysis, SPC, and PAT, with experience integrating experimental and manufacturing data into models.Experience with advanced modeling approaches, such as:Reduced-order modeling (ROM)Physics-informed neural networks (PINNs)Hybrid mechanistic / machine learning modelsCFD-ML surrogate models for rapid decision makingPrior contributions to technology transfer, process robustness assessments, or troubleshooting using modeling and simulation are a strong plus.#AR&DRequired Skills: Adaptability, Analytical Method Development, Assay Development, Bioanalytical Analysis, Biochemical Assays, Cell-Based Assays, Chromatographic Techniques, GMP Environments, Innovative Thinking, Nuclear Magnetic Resonance (NMR) Analysis, Process Analytical Technology (PAT), Strategic Thinking, Technical Writing, Ultra Performance Liquid Chromatography (UPLC)Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.

We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is $117,000.00 - $184,200.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee).

The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.

-No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-Employee Status: RegularRelocation:DomesticVISA Sponsorship:No Travel Requirements: 10%Flexible Work Arrangements:HybridShift:Not IndicatedValid Driving License:NoHazardous Material(s):n/aJob Posting End Date:06/18/2026 *A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date.

Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID:R401241 Salary: . Date posted: 06/05/2026