The Hospital of the University of Pennsylvania (HUP) is a preeminent medical establishment situated in Philadelphia, PA, US. Founded in 1874, it functions under a mission to provide high-quality patient care, conduct innovative medical research, and offer professional development and education to health care professionals and biomedical scientists. As an integral part of Penn Medicine, a world-renowned academic medical center, HUP belongs to the health and medical industry, primarily offering a wide array of services and specialties including cancer treatment, cardiac care, neurological care, and trauma, among many others. HUP is renowned for medical innovation, noted for carrying out the world's first total intravenous anesthesia and the first double-lung transplant in the Philadelphia region.