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In Situ Hybridization Jobs (NOW HIRING)

KA Recruiting Inc.

Histotechnologist

Buffalo, NY · On-site

Process and prepare fixed and unfixed tissue and cytology specimens using histologic, frozen sectioning, immunohistochemical, in situ hybridization, and tissue microarray techniques. * Competitive ...

Caris Life Sciences

Oncologic Pathologist

Phoenix, AZ · On-site

Provide interpretation of in-situ hybridization (ISH) stains. * Review batch and instrument quality control stains as needed. * Evaluate pathology specimens and render insightful and comprehensive ...

Caris Life Sciences

Oncologic Pathologist

Phoenix, AZ · On-site

Provide interpretation of in-situ hybridization (ISH) stains. * Review batch and instrument quality control stains as needed. * Evaluate pathology specimens and render insightful and comprehensive ...

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In Situ Hybridization information

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How much do in situ hybridization jobs pay per hour?

As of Aug 15, 2026, the average hourly pay for in situ hybridization in the United States is $22.51, according to ZipRecruiter salary data. Most workers in this role earn between $18.51 and $24.04 per hour, depending on experience, location, and employer.

What is the difference between In Situ Hybridization vs Cytogenetic Technologist?

AspectIn Situ HybridizationCytogenetic Technologist
Required CredentialsTypically requires a bachelor's degree in biology, molecular biology, or related field; certification may be preferredRequires a bachelor's degree in biology, genetics, or related field; certification often recommended
Work EnvironmentLaboratory settings focusing on molecular and cellular analysisLaboratories performing chromosome analysis and genetic testing
Industry UsageUsed in research, diagnostics, and pathology labs for detecting nucleic acid sequencesUsed in clinical genetics labs for karyotyping and genetic diagnosis

In Situ Hybridization and Cytogenetic Technologists both work in laboratory settings within the genetics and molecular biology fields. While In Situ Hybridization focuses on detecting specific nucleic acid sequences within cells, Cytogenetic Technologists analyze chromosomes for genetic abnormalities. Both roles require similar educational backgrounds and are essential in genetic diagnostics, but they specialize in different techniques and analysis methods.

What are the key skills and qualifications needed to thrive as an in situ hybridization specialist?

To thrive as an In Situ Hybridization Specialist, you need a solid background in molecular biology, histology, and laboratory techniques, usually supported by a degree in a biological science. Proficiency in using laboratory instruments such as microtomes, microscopes, and imaging systems, as well as familiarity with protocols like FISH and RNAscope, is essential. Attention to detail, problem-solving skills, and effective communication are valuable soft skills that enhance accuracy and collaboration. These qualifications ensure precise experimental results, reliable data interpretation, and successful teamwork in research or diagnostic settings.

What are some common challenges faced by professionals working in in situ hybridization, and how can they be addressed?

Professionals working in In Situ Hybridization often encounter challenges such as optimizing probe specificity, minimizing background staining, and maintaining sample integrity. These issues can affect the clarity and reliability of results. Addressing them typically involves rigorous protocol optimization, careful reagent selection, and thorough troubleshooting. Additionally, collaboration with pathologists, molecular biologists, and lab technicians is crucial for interpreting results and refining techniques. Continuous training and staying updated on new ISH methodologies can further help overcome these challenges.

What is in situ hybridization?

In situ hybridization (ISH) is a laboratory technique used to detect specific nucleic acid sequences (DNA or RNA) within fixed tissues or cells. This method uses labeled probes that bind to complementary sequences, allowing researchers to visualize the location, abundance, and distribution of target genes or transcripts directly in their cellular context. ISH is widely used in research and diagnostics to study gene expression patterns, identify genetic abnormalities, and investigate infectious agents in tissue samples.

How to do in situ hybridization?

In situ hybridization is a laboratory technique used by molecular biologists to detect specific nucleic acid sequences within tissue sections or cell samples. The process involves preparing samples, applying a labeled complementary DNA or RNA probe, hybridizing under controlled conditions, and then visualizing the bound probe using microscopy. Proper technique, probe design, and adherence to safety protocols are essential for accurate results.
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In Situ Hybridization jobs near you
Infographic showing various In Situ Hybridization job openings in the United States as of August 2026, with employment types broken down into 96% Full Time, 3% Part Time, and 1% Contract. Highlights an 94% Physical, 3% Hybrid, and 3% Remote job distribution, with an average salary of $46,828 per year, or $22.5 per hour.

Research Associate, Molecular Biology

Colossal Biosciences

Dallas, TX • On-site

Full-time

Posted 11 days ago

Job description

An affiliate of Colossal is seeking a motivated and detail-oriented Research Associate to join our interdisciplinary team at the intersection of molecular and developmental biology. This role offers the opportunity to work closely with scientists developing cutting-edge approaches to drive novel applications in the modification of phenotypes in avians. The successful candidate will support ongoing research projects by performing a range of cellular and tissue-based assays, including in situ hybridization, flow cytometry, histology, and immunofluorescence staining. 

This role is based in Dallas, TX. Relocation assistance is available.

Duties and Responsibilities

  • Collaborate with developmental biologists to analyze gene expression and function across different developmental stages.
  • Perform in situ hybridization (ISH) to localize and quantify RNA/DNA targets in tissue and whole embryo samples
  • Prepare and process tissue samples for histology, including sectioning, fixation, and staining (H&E and special stains)
  • Perform immunofluorescence (IF) staining and support imaging/microscopy workflows
  • Conduct flow cytometry experiments, including sample preparation, staining panel setup, data acquisition, and basic analysis
  • Screen constructs in developing avian embryos to quantify expression patterns.
  • Produce transfection reagents to aid experimental workflows.
  • Analyze and interpret experimental data, providing recommendations to guide project direction.
  • Participate in meetings, generate reports, and present findings to ensure alignment with project milestones.
  • Maintain accurate, detailed laboratory records and demonstrate strong organizational skills.

Required Skills and Qualifications

  • Bachelor's degree (B.S./B.A.) in molecular biology, or a related life science field with 1 or more years of hands-on research experience in industry or academic research labs.
  • Hands-on experience in molecular cloning, plasmid construction, and plasmid preparation (mini-, midi-, and maxi-prep).
  • Demonstrated hands-on experience with at least two of the following: microscopy (confocal and/or lightsheet), in situ hybridization, flow cytometry, histology, immunofluorescence staining, (experience with all four strongly preferred)
  • Skilled in PCR primer design and PCR optimization/troubleshooting.
  • Strong organizational skills with the ability to manage multiple projects simultaneously and meet deadlines.
  • Excellent written and oral communication skills, with demonstrated problem-solving abilities.

Preferred Skills and Abilities

  • Experience handling vertebrate embryos.
  • Familiarity with microscopy/imaging software (e.g., Imaris, ImageJ or similar)
  • Experience with transfection reagents (i.e. lipofectamine or electroporation)
  • Familiarity with high-throughput automation platforms for molecular biology workflows.

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