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In Situ Hybridization Jobs (NOW HIRING)

HistoWiz, Inc

Research Scientist

Long Island City, NY · On-site

$90K - $110K/yr

... RNA in-situ hybridization, and related biomarker applications. The role will also contribute to the development of new services, products, and scientific capabilities while mentoring junior ...

CYNET SYSTEMS

Clinical Lab Scientist I

Tucson, AZ · On-site

$30 - $32/hr

Experience with Immunohistochemistry (IHC), chromogenic in-situ hybridization (ISH), and histology lab environments. * Experience with CAP/CLIA regulations, immunoassays, and molecular biology.

McLaren

Molecular Pathology Technologist

Flint, MI · On-site

... In Situ Hybridization (FISH), endpoint, real-time and multiplexed PCR, traditional Sanger and massively parallel (NGS) sequencing techniques. 4. Perform automated and manual antigen and molecular ...

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In Situ Hybridization information

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How much do in situ hybridization jobs pay per hour?

As of Sep 6, 2026, the average hourly pay for in situ hybridization in the United States is $22.51, according to ZipRecruiter salary data. Most workers in this role earn between $18.51 and $24.04 per hour, depending on experience, location, and employer.

What is in situ hybridization?

In situ hybridization (ISH) is a laboratory technique used to detect specific nucleic acid sequences (DNA or RNA) within fixed tissues or cells. This method uses labeled probes that bind to complementary sequences, allowing researchers to visualize the location, abundance, and distribution of target genes or transcripts directly in their cellular context. ISH is widely used in research and diagnostics to study gene expression patterns, identify genetic abnormalities, and investigate infectious agents in tissue samples.

What are the key skills and qualifications needed to thrive as an in situ hybridization specialist?

To thrive as an In Situ Hybridization Specialist, you need a solid background in molecular biology, histology, and laboratory techniques, usually supported by a degree in a biological science. Proficiency in using laboratory instruments such as microtomes, microscopes, and imaging systems, as well as familiarity with protocols like FISH and RNAscope, is essential. Attention to detail, problem-solving skills, and effective communication are valuable soft skills that enhance accuracy and collaboration. These qualifications ensure precise experimental results, reliable data interpretation, and successful teamwork in research or diagnostic settings.

What are some common challenges faced by professionals working in in situ hybridization, and how can they be addressed?

Professionals working in In Situ Hybridization often encounter challenges such as optimizing probe specificity, minimizing background staining, and maintaining sample integrity. These issues can affect the clarity and reliability of results. Addressing them typically involves rigorous protocol optimization, careful reagent selection, and thorough troubleshooting. Additionally, collaboration with pathologists, molecular biologists, and lab technicians is crucial for interpreting results and refining techniques. Continuous training and staying updated on new ISH methodologies can further help overcome these challenges.

What is the difference between In Situ Hybridization vs Cytogenetic Technologist?

AspectIn Situ HybridizationCytogenetic Technologist
Required CredentialsTypically requires a bachelor's degree in biology, molecular biology, or related field; certification may be preferredRequires a bachelor's degree in biology, genetics, or related field; certification often recommended
Work EnvironmentLaboratory settings focusing on molecular and cellular analysisLaboratories performing chromosome analysis and genetic testing
Industry UsageUsed in research, diagnostics, and pathology labs for detecting nucleic acid sequencesUsed in clinical genetics labs for karyotyping and genetic diagnosis

In Situ Hybridization and Cytogenetic Technologists both work in laboratory settings within the genetics and molecular biology fields. While In Situ Hybridization focuses on detecting specific nucleic acid sequences within cells, Cytogenetic Technologists analyze chromosomes for genetic abnormalities. Both roles require similar educational backgrounds and are essential in genetic diagnostics, but they specialize in different techniques and analysis methods.

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In Situ Hybridization jobs near you
Infographic showing various In Situ Hybridization job openings in the United States as of August 2026, with employment types broken down into 94% Full Time, 5% Part Time, and 1% Contract. Highlights an 92% Physical, 4% Hybrid, and 4% Remote job distribution, with an average salary of $46,828 per year, or $22.5 per hour.

Histology Technologist in Buffalo New York

KA Recruiting Inc.

Buffalo, NY • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 24 days ago

Job description

Full Time Histotechnologist needed in Buffalo, New York! Apply now for an interview!

Position Highlights:

  • Full-time, permanent job opportunity
  • Full benefits package (401k, PTO, medical/dental/vision insurance)
  • Competitive pay
  • Room for career growth!

Job Duties:

  • Process and prepare fixed and unfixed tissue and cytology specimens using histologic, frozen sectioning, immunohistochemical, in situ hybridization, and tissue microarray techniques
     
    Teach and instruct other lab staff in these techniques (1-3)
     
    Supervise and train new staff or students as needed, including hiring, performance management, and related duties, in addition to instruction on techniques and consultation on project work
     
    Prepares microscopic slides for diagnostic processing, embedding, microtomy, mounting (paraffin/frozen sections), staining (routine/special/IHC), slide and block labeling & coverslipping
     
    Performs special staining techniques for interstitial elements of tissue sections to include micro-organisms and various cellular components including antigens and enzymes for complex diagnosis and prognostic markers
     
    Contribute to corporate strategy for additional regulatory approvals (CAP, FDA, ) relating to GHI Histopathology
     
    Assess the quality of slide preparations and troubleshoot procedures if necessary
     
    Prepare control slides and in collaboration with the laboratory director, validate technical procedures before applying to clinical or research samples
     

Position Requirements:

  • Associate's Degree in Science (or higher)
  • ASCP (HT or HTL) or eligible to obtain
  • Experience is preferred (but not required!)
  • NYS Licensure to work in the laboratory required

Interested? Apply to this job or send a resume to marissak@ka-recruiting.com for consideration!

(REF: MK51912)

Apply