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Histocompatibility Director information

What is a histocompatibility director?

Histocompatibility Directors are specialized laboratory professionals responsible for overseeing histocompatibility and immunogenetics laboratories, which perform testing to determine tissue compatibility for organ, tissue, or bone marrow transplantation. They ensure the accuracy and quality of tests that match donors and recipients, supervise laboratory staff, maintain compliance with regulatory standards, and often participate in clinical decision-making for transplant cases. These directors typically hold advanced degrees in immunology, pathology, or a related field, and are certified by relevant boards. Their expertise is critical to the success and safety of transplant procedures.

What are some common challenges a histocompatibility director faces when overseeing laboratory operations?

A Histocompatibility Director often encounters challenges such as staying current with rapidly evolving testing technologies, ensuring compliance with stringent regulatory standards (like those from ASHI or CAP), and managing a multidisciplinary team of technologists and clinicians. Balancing administrative duties with hands-on oversight of complex testing procedures and interpreting ambiguous results can also be demanding. Additionally, fostering effective communication between the lab and transplant teams is essential for timely and accurate patient care.

What are the key skills and qualifications needed to thrive as a histocompatibility director, and why are they important?

To thrive as a Histocompatibility Director, you need in-depth knowledge of immunogenetics, laboratory management, and transplantation science, typically supported by a doctoral degree and certification such as ABHI (American Board of Histocompatibility and Immunogenetics) director-level credentials. Familiarity with molecular diagnostics platforms, HLA typing technologies, and laboratory information management systems (LIMS) is essential. Strong leadership, problem-solving, and communication skills help in managing teams, ensuring regulatory compliance, and collaborating with clinicians. These skills and qualifications are crucial for accurate testing, patient safety, and the effective functioning of transplant programs.

What is the difference between Histocompatibility Director vs Histocompatibility Laboratory Supervisor?

AspectHistocompatibility DirectorHistocompatibility Laboratory Supervisor
CredentialsTypically requires certification (e.g., ASHI), advanced degree, leadership experienceCertifications preferred, technical expertise, laboratory experience
Work EnvironmentOversees entire histocompatibility program, administrative and leadership dutiesManages daily lab operations, supervises technical staff
Employer & IndustryHospitals, transplant centers, reference labsLaboratories within healthcare or research institutions

The main difference is that the Histocompatibility Director holds a leadership role overseeing the entire program, including administrative responsibilities, while the Histocompatibility Laboratory Supervisor manages daily technical operations and staff. Both roles require specialized certifications and experience, but the director's role is broader and more strategic.

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Histocompatibility Director jobs near you
Infographic showing various Histocompatibility Director job openings in the United States as of August 2026, with employment types broken down into 2% As Needed, 83% Full Time, 12% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution.

Histocompatibility and Immunology, Laboratory Assistant/Associate Director - Allogen Laboratories

Cleveland Clinic Foundation

Cleveland, OH

Full-time

Medical, Life, Retirement, PTO

Posted 9 days ago

Cleveland Clinic rating

7.2

Company rating: 7.2 out of 10

Based on 911 frontline employees who took The Breakroom Quiz

345th of 891 rated healthcare providers

Job description

Section of Histocompatability/Division of laboratory Medicine/Robert J. Tomsich Department of Pathology and Laboratory Medicine/Diagnostics Institute of Cleveland Clinic is looking for an assistant/associate director to support the histocompatibility clinical services of Allogen laboratories.  Allogen is an American Society for Histocompatibility and Immunogenetics (ASHI) accredited laboratory that provides histocompatibility testing and clinical consulting for bone marrow (BMT) and solid organ transplant (SOT) programs, supporting approximately 1000 transplants annually and donor typing for a local Organ Procurement Organization (OPO).   

Requirements

Candidates should hold an earned M.D. and/or Ph.D. degree and meet the histocompatibility director qualifications set by the American College for Histocompatibility and Immunogenetics (ACHI). Individuals who are currently training in histocompatibility or who qualify for Director-in-Training status through ACHI, with the goal of becoming ACHI-credentialed, will also be considered.

Experience and training in a high-complexity, ASHI-certified/eligible clinical laboratory supporting SOT and BMT, as well as knowledge of transplantation immunology, will be strongly considered. An academic background and a willingness to engage in clinical research are highly desirable.

Key Responsibilities:

  1. Collaboratively works with director in the overall laboratory management
  2. Assists in assessing, validating, and implementing state-of-the-art technologies
  3. Reviews and approves the critical test results/reports
  4. Provides histocompatibility consultations for clinical staff served by Allogen, including participation in the on-call schedule.
  5. Assumes shared responsibility for histocompatibility education of laboratory testing staff, rotating medical students, residents, fellows, and transplantation staff.
  6. Participates in clinical research

While the primary responsibilities of this position are within the Allogen Laboratory as described above, requests from Clinical Pathologytrained MD candidates to incorporate clinical practice in another relevant subspecialty (e.g., Transfusion Medicine) will be considered. A faculty appointment at a rank commensurate with experience is available at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

Contact for additional information:

Aiwen Zhang, PhD

Section head of Histocompatibility/Director of Allogen Laboratories

Zhanga2@ccf.org

David S. Bosler, MD

Chair, Department of Laboratory Medicine

boslerd@ccf.org

  • Very attractive salary, 401(a) Investment Pension Plan and 403(b) Match, Exceptional Health Care Coverage.
  • Generous paid time off, holidays, personal and wellness day, maternity and parental leave.
  • Work life balance, flexible scheduling available.
  • Ongoing development of your professional skills through CCFs training programs and mentorships.

 Cleveland offers an outstanding quality of life with a vibrant cultural scene, nationally recognized healthcare and education, affordable housing, strong school systems, and easy access to arts, sports, and outdoor recreationall contributing to an excellent environment for both professional and family life.

 

 

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