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Senior Director Biostatistics, Head of Statistical Innovation & Methodology Overview At Alnylam, the Senior Director Biostatistics, Head of Statistical Innovation & Methodology will provide scientific leadership in advanced statistical methodology, innovative trial design and simulation-based approaches, with a focus on developing, evaluating, and implementing fit-for-purpose methods to address complex design and analysis challenges across clinical development. Reporting to the Head of Biostatistics, this role will help shape and advance statistical strategies across programs while providing thought leadership on emerging methodologies. The position serves as the internal expert and strategic leader for statistical innovation, working closely with cross-functional teams to ensure the application of rigorous and innovative statistical approaches aligned with regulatory expectations and industry best practices, while fostering a culture of methodological excellence and continuous learning within the biostatistics organization.

This position is hybrid onsite and remote working and will be primarily located at Cambridge or Philadelphia. Key Responsibilities Lead the identification, development, evaluation, and application of innovative statistical methodologies to support clinical development programs. Conduct and oversee methodological research on emerging statistical approaches, and guide the development of tools, algorithms, and analytical frameworks to enable their practical implementation in clinical development.

Provide expert statistical consultation to clinical development teams, influencing program-level and portfolio-level decisions through rigorous quantitative evaluation and methodological insight. Shape statistical strategies for clinical trial design and analysis, including the development of quantitative decision frameworks, benefit-risk evaluations, and probability-of-success assessments. Serve as an internal subject-matter expert on advanced statistical methodologies, advising statisticians and cross-functional teams on complex design and analysis challenges.

Engage externally with scientific organizations, regulatory agencies, and academic collaborators to contribute to methodological advancement, inform industry best practices, and ensure awareness of emerging statistical approaches. Mentor statisticians, promote knowledge sharing, and, as the function grows, build and lead a statistical innovation and methodology team to strengthen methodological expertise and foster a culture of statistical innovation within the Biostatistics organization. Qualifications PhD in Statistics, Biostatistics, or a related quantitative discipline with 12+ years of experience in the pharmaceutical or biotechnology industry, including experience in statistical methodology or innovation roles.

Strong expertise in clinical trial design, modern statistical methodologies, and simulation-based evaluation of trial operating characteristics. Proven track record of developing or applying advanced statistical methods to support drug development (e.g., adaptive designs, Bayesian methods, model-based decision frameworks). Experience providing methodological guidance to statisticians and cross-functional teams

Demonstrated ability to mentor statisticians, lead methodological initiatives, and communicate complex statistical concepts clearly to scientific and non-statistical stakeholders. U.S. Pay Range $246,500.00 - $333,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting

Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being

We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave.

Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible

Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity.

Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.