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A postdoctoral position focused on cellular danger response signaling and interaction with the tumor immune microenvironment in renal cell carcinoma is available in the laboratory of Dr. Eric Jonasch. We are looking for highly self-motivated candidates with a recent PhD or MD degree, to investigate the cellular and molecular mechanisms of STING pathway signaling in renal cell carcinoma as well as therapy resistance to targeted therapy and immunotherapy.
To study the cellular and molecular mechanisms of cellular danger response in renal cell carcinoma as well as therapy resistance to chemotherapy, targeted therapy, and immunotherapy.
Successful candidate must be able to design novel projects, create hypothesis-driven experiment, maintain excellent descriptions of experiments performed, standardize and validate new methods and be able to interpret results. Computer skills such as entering data obtained from experiments into graphic and statistics programs as well as the generation of figures after image analysis are essentials. The employee should provide scientific expertise and organizational skills in getting involved in various research projects involving human subject research. Candidate will be responsible for coordinating procedures with collaborators. Other skills include performing technical laboratory duties in accordance with general and/or specific plans. Read, write and edit manuscripts and reports, as well as help with grant writing.
All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.
LEARNING OBJECTIVES
-Develop capabilities for perform spatial transcriptomic analyses on RCC and VHL disease related samples.
-Develop and expand the ability to perform bioinformatic analyses of single cell and spatial transcriptomic analysis.
-Become proficient in the intersection of tumor immune microenvironment, tumor metabolism, tumor microbiome, disease progression and treatment response in patients with nodal disease.
-Learn metastatic and primary tumor tissue processing and clinical annotation in patients with locally advanced and metastatic disease.
To accomplish the learning objective, the candidate will be matched with GU oncology clinical faculty (Dr. Eric Jonasch as well as translational faculty (Dr. Xiande Liu).
ELIGIBILITY REQUIREMENTS
MD or PhD (recent, within 3 years)
- Prefer candidate to have knowledge of tissue processing for single cell studies, metabolomics, and microbiome studies
- Prefer candidate with skills in clinical database management and clinical specimen annotation.
ADDITIONAL APPLICATION INFORMATION
- Prefer candidate to have knowledge of tissue processing for single cell studies, metabolomics, and microbiome studies
- Prefer candidate with skills in clinical database management and clinical specimen annotation.
POSITION INFORMATION
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000 . depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits , including medical, dental, paid time off , retirement , tuition benefits, educational opportunities, and individual and team recognition
Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.
This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html