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Flexible Protein Biochemistry Postdoc Jobs (NOW HIRING)

Postdoctoral Fellow, Neurology

Galveston, TX · On-site

$46K - $62K/yr

The postdoctoral fellow will conduct, report and present research in his/her field of study under ... Investigate the biochemistry and cellular mechanisms for the formation and toxicity in protein ...

The postdoctoral fellow will conduct, report and present research in his/her field of study under ... Investigate the biochemistry and cellular mechanisms for the formation and toxicity in protein ...

Postdoctoral Fellow, Neurology

Galveston, TX · On-site

$46K - $62K/yr

The postdoctoral fellow will conduct, report and present research in his/her field of study under ... Investigate the biochemistry and cellular mechanisms for the formation and toxicity in protein ...

Experience in protein expression and purification and in biochemical characterization of proteins ... Medical,prescription drug,dental,vision,life and AD&D,flexible spending accounts,and long-term ...

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Flexible Protein Biochemistry Postdoc information

What does a flexible protein biochemistry postdoc do?

A Flexible Protein Biochemistry Postdoc is a research scientist who investigates the structure, function, and dynamics of proteins, often with a focus on protein flexibility and conformational changes. They design and conduct experiments using techniques such as X-ray crystallography, NMR spectroscopy, cryo-EM, and computational modeling to understand how protein flexibility impacts biological processes. Their work supports advancements in drug discovery, biotechnology, and fundamental science, often collaborating with multidisciplinary teams.

What are the key skills and qualifications needed to thrive as a flexible protein biochemistry postdoc?

To thrive as a Flexible Protein Biochemistry Postdoc, you need a PhD in biochemistry or a related field, with expertise in protein expression, purification, and characterization. Experience with advanced techniques such as NMR spectroscopy, X-ray crystallography, or mass spectrometry, as well as proficiency in data analysis software, is typically required. Strong problem-solving skills, attention to detail, and effective collaboration and communication abilities are essential soft skills. These competencies are crucial for driving innovative research, producing reliable results, and contributing effectively within multidisciplinary scientific teams.

What are some common challenges faced by postdocs in flexible protein biochemistry, and how can they be addressed?

Postdocs in flexible protein biochemistry often encounter challenges such as expressing and purifying dynamic or disordered proteins, which may not behave predictably compared to structured proteins. Additionally, interpreting experimental data from techniques like NMR or cryo-EM, which are sensitive to protein flexibility, can be complex and time-consuming. These challenges can be addressed by collaborating closely with structural biologists, leveraging advanced computational tools, and staying updated on new protocols for handling intrinsically disordered proteins. Regular communication with interdisciplinary teams and attending specialized workshops can also enhance problem-solving and technical skills in this evolving field.
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Infographic showing various Flexible Protein Biochemistry Postdoc job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 67% Full Time, 29% Part Time, and 3% Contract. Highlights an 88% Physical, 1% Hybrid, and 11% Remote job distribution.

Full-time

Re-posted 28 days ago


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Job description

GENERAL REQUISITION INFORMATION
EEO Statement:
UNMC is an Equal Employment Opportunity Employer, including an equal opportunity employer of protected veterans and individuals with disabilities.
Location Omaha, NE Requisition Number: 2026 - 279 Department Pathology, Microbiology & Immunology 50000521 Business Unit(College/Institute) College of Medicine FTE:
100
Reg-Temp Full-Time Regular Work Schedule Monday - Friday, 8:00AM - 5:00PM; some evening or weekends Requisition Category Research - Academic Requisition Title Postdoctoral Research Associate Job Title/Academic Rank Postdoctoral Research Associate Additional Requisition Title Appointment Type A1 - REG OTHER ACAD SAL Salary Range Salary is commensurate with experience Job/EEO Category Professional Non-Faculty (Includes Other Academic) Job Requisition Begin Date 08/10/2026
Position Qualification
Position Summary
Dr. Jian Xie's laboratory in the Department of Pathology, Microbiology, and Immunology at the University of Nebraska Medical Center (UNMC), a nationally recognized institution ranked Tier 1 in Primary Care and Tier 2 in Research, is seeking an outstanding candidate for a Postdoctoral Research Associate position. The successful candidate will investigate the roles of cell surface RNAs and glycoRNAs in viral entry and infection, with a particular emphasis on oncogenic viruses such as human papillomavirus (HPV).

Although RNA was traditionally considered to be confined to the nucleus and cytoplasm, recent studies have revealed that a subset of RNAs is glycosylated and displayed on the cell surface (cell surface glycoRNAs) (Cell, 2021; Cell, 2024; Nature, 2026). These discoveries have further led to the unexpected finding that RNA-binding proteins (RBPs) are common components of the cell surface (Cell, 2025; Nature Biotechnology, 2025; Molecular Cell, 2025). Positioned at the interface between the cell and its environment, cell surface RNAs (csRNAs) and cell surface RNA-binding proteins (csRBPs) are strategically situated to regulate fundamental biological processes, including cell-cell communication, pathogen recognition, and receptor-mediated signaling. Emerging evidence suggests that these newly identified surface molecules form functional complexes with important roles in immune regulation and cancer biology (Cell, 2024; Nature, 2025). However, the mechanistic principles governing their functions during pathogen infection remain unknown.
The Xie laboratory studies virus-host interactions in viral infection, cancer, and innate immunity (PNAS, 2026; PNAS, 2025; Science Advances, 2021; Cell Reports, 2020). Our recent work indicates that csRNAs and csRBPs are critical determinants of HPV infection and may constitute a previously unrecognized class of viral entry receptors. This research is supported by an NIH R35 award and is conducted through strong collaborations with leading laboratories at Yale University and Harvard University. https://www.ncbi.nlm.nih.gov/myncbi/jian.xie.3/bibliography/public/

The successful candidate will receive individualized, mentor-guided training and gain access to emerging concepts, experimental systems, and technologies developed by the laboratory and its collaborators. The candidate will design and conduct studies involving RNA and protein biochemistry, virology, cell biology, and molecular biology. Responsibilities will include experimental design; data collection, analysis, and interpretation; presentation of findings at institutional, regional, national, and international scientific meetings; preparation of manuscripts and grant applications; and mentoring of graduate students and other junior researchers, as appropriate. The ideal candidate will be highly motivated, creative, collaborative, and intellectually independent, with a strong interest in developing innovative hypotheses and experimental approaches.
Applicants must submit a CV, a cover letter describing their research interests, experience, and career goals, and contact information for three references.
Questions regarding the position may be directed to Jian Xie, PhD.
Required Qualifications
Ph.D. in RNA biology, cell biology, biochemistry, virology/microbiology, immunology, genetics, biological sciences, or related field.
Supplemental Qualifications
Experience in RNA biochemistry, molecular and cellular biology is required.
Direct experience with proteomics, live cell imaging or super-resolution, virology, or protein biochemistry is preferred.

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