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Legend Biotech is seeking an Executive Director, Global Program Leader as part of the Research & Development team based in Somerset, NJ.

Role Overview

The Executive Director, Global Program Leader (GPL) is a senior strategic leadership role responsible for the overall development, execution, and governance of Legend Biotech's in vivo CAR-T programs.

Reporting directly to the President of R&D, the GPL serves as the single point of accountability for leading cross-functional teams to define and execute integrated global development strategies from IND enabling through clinical proof-of-concept, late-stage development, registration, and lifecycle management. The GPL ensures alignment of program strategy, timelines, resources, and operational execution across Research, Clinical Development, Regulatory Affairs, Translational Sciences, Technical Development, Manufacturing, Commercial, Business Development, and other key functions.

The successful candidate will combine strong scientific and clinical development expertise with exceptional leadership, strategic thinking, and execution capabilities to advance innovative in vivo CAR-T therapies for patients worldwide.

Key Responsibilities

• Partner closely with Clinical Development and Regulatory Affairs to design efficient development pathways that maximize speed to proof-of-concept, pivotal development, and global approvals.

• Guide critical regulatory interactions and major health authority milestones.

• Ensure readiness and alignment for INDs, CTAs, BLA/MAA submissions, and lifecycle management activities.

• Chair Global Program Teams and provide leadership across all functional areas involved in program execution.

• Foster effective collaboration among Research, Translational Medicine, Clinical Development, Regulatory Affairs, Biometrics, CMC, Quality, Manufacturing, Commercial, Finance, and Business Development.

• Drive cross-functional problem-solving and ensure timely resolution of strategic and operational risks.

• Establish clear governance processes, decision frameworks, and accountability mechanisms.

• Present program strategies, risks, and recommendations to executive leadership and governance committees.

• Lead preparation of development scenarios, investment analyses, milestone recommendations, and portfolio reviews.

• Provide regular updates to senior management on program status, emerging opportunities, and critical risks.

• Ensure effective risk management and contingency planning throughout development.

• Represent Legend Biotech in interactions with external partners, collaborators, investigators, key opinion leaders, and other stakeholders.

• Support business development assessments, diligence activities, and partnership opportunities related to in vivo CAR-T technologies.

• Serve as a scientific and strategic ambassador for Legend's in vivo CAR-T platform.

• Build a high-performance, patient-focused, and collaborative program culture.

• Mentor and develop program management and cross-functional team members.

• Champion innovation, accountability, and operational excellence across development teams.

Requirements

• MD, PhD, PharmD, or equivalent advanced scientific or medical degree required.

• Advanced training in oncology, immunology, cell and gene therapy, hematology, or related disciplines preferred.

• Minimum 10+ years of biotechnology or pharmaceutical industry experience in drug development.

• Minimum 5+ years of leadership experience managing complex, global development programs.

• Demonstrated success advancing biologics, cell therapies, gene therapies, or other advanced therapeutic programs through clinical development.

• Direct experience leading cross-functional development teams in a matrix environment.

• Experience supporting global regulatory interactions and major regulatory submissions.

• Experience in oncology, immunology, cell therapy, gene therapy, or in vivo genetic medicines strongly preferred.

• Deep understanding of global drug development, clinical development, and registration pathways.

• Strong knowledge of cell and gene therapy development, including emerging in vivo CAR-T technologies.

• Exceptional strategic thinking and portfolio management capabilities.

• Demonstrated ability to influence senior leaders and drive decisions in complex environments.

• Outstanding communication, presentation, and executive stakeholder management skills.

• Strong business acumen, financial awareness, and risk-management capabilities.

• Proven ability to lead diverse global teams and achieve ambitious development goals.

• Ability to operate effectively in a dynamic, fast-paced biotechnology environment.

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