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Downstream Purification Jobs (NOW HIRING)

This role supports the execution of cell culture processes and downstream purification within a pilot-scale lab environment. The ideal candidate will have hands-on experience in cell culture ...

Purification Scientist

Boston, MA · On-site

$44 - $46/hr

Monday-Friday | 8:00 AM-5:00 PM (40 hrs/week Position Summary Seeking an early-career Biologist / Purification Scientist to join the Downstream Process Development team in Boston, MA. This role will ...

Field Application Scientist

Boston, MA · On-site

$157.90K - $236.90K/yr

Provide technical leadership by demonstrating application and theoretical knowledge of chromatography and downstream purification to design-inPuroliteResins. * Deliver scientific support for ...

$46.30K - $62.80K/yr

Characterize protein purification and downstream unit operations including clarification, centrifugation, depth filtration, and sterile filtration to understand their impact on product yield, purity ...

Field Application Scientist

Boston, MA · On-site

$157.90K - $236.90K/yr

Provide technical leadership by demonstrating application and theoretical knowledge of chromatography and downstream purification to design-in Purolite Resins. * Deliver scientific support for ...

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Downstream Purification information

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How much do downstream purification jobs pay per hour?

As of May 31, 2026, the average hourly pay for downstream purification in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Downstream Purification, and why are they important?

To excel in Downstream Purification, you need a solid background in biochemistry or chemical engineering, with experience in protein purification techniques and a relevant degree. Familiarity with chromatography systems (e.g., AKTA), filtration technologies, and good manufacturing practice (GMP) certification is highly valuable. Strong analytical thinking, attention to detail, and effective teamwork are important soft skills in this role. These competencies ensure the efficient and reliable production of high-purity biopharmaceutical products, critical for product quality and regulatory compliance.

What are some common challenges faced in a Downstream Purification role, and how can they be addressed?

Professionals in Downstream Purification often encounter challenges such as maintaining product yield and purity, troubleshooting equipment malfunctions, and adapting to process variability. Addressing these requires strong analytical skills, attention to detail, and close collaboration with upstream teams and quality assurance. Continuous training on the latest purification technologies and strict adherence to standard operating procedures also help minimize errors and improve efficiency in the production process.

What is downstream purification?

Downstream purification refers to the series of processes used to isolate and purify a target product, such as a protein or antibody, from a complex mixture after it has been produced by cells or microorganisms. This is a critical step in biotechnology and pharmaceutical manufacturing, involving techniques like filtration, chromatography, and centrifugation to remove impurities and contaminants. The goal is to achieve a high level of purity and quality for the final product, ensuring it meets regulatory standards for use in research, diagnostics, or therapeutics.

What is the difference between Downstream Purification vs Downstream Processing?

AspectDownstream PurificationDownstream Processing
FocusPurifying specific products from a mixtureOverall process including purification and initial recovery
CredentialsTypically requires bioprocessing or biotech certificationsSimilar credentials, often overlapping
Work EnvironmentLaboratories, clean rooms, manufacturing facilitiesLabs and production plants
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical, and bioprocessing industries

Downstream Purification is a specialized part of the broader Downstream Processing. While downstream processing includes all steps from initial product recovery to purification, downstream purification specifically focuses on isolating and purifying the target product. Both roles often require similar skills and certifications, and they operate in comparable environments within biotech and pharmaceutical industries.

More about Downstream Purification jobs
What cities are hiring for Downstream Purification jobs? Cities with the most Downstream Purification job openings:
What states have the most Downstream Purification jobs? States with the most job openings for Downstream Purification jobs include:
Infographic showing various Downstream Purification job openings in the United States as of May 2026, with employment types broken down into 82% Full Time, 12% Part Time, 1% Temporary, and 5% Contract. Highlights an 57% Physical, 10% Hybrid, and 33% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Scientist, Downstream Process Development

Bristol Myers Squibb

Devens, MA

$103.08K - $124.91K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted yesterday


Job description

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary:

The Scientist position will be part of the Biologics Downstream Development department in Devens, MA that is responsible for early and late stage process development of BMS' growing biologics pipeline. The candidate will be responsible for developing efficient, robust, and scalable downstream purification processes - including chromatography and filtration unit operations - for therapeutic biologics. The candidate will be working in a dynamic and collaborative team environment with opportunities to lead development and matrix teams, while enhancing our ever-growing biologics portfolio.

Key Responsibilities:

  • Develop and implement scalable purification processes for biologics drugs to meet established timelines.
  • Design, execute and perform data analysis for downstream process development laboratory studies, including protein A affinity, ion exchange, hydrophobic interaction, and mixed-mode chromatography, as well as ultrafiltration/diafiltration (UF/DF), membrane filtration and depth filtration processes.
  • Organize and interpret results, present to matrix team and management.
  • Support process scale-up and tech transfer activities in pilot plant and clinical manufacturing sites.
  • Support clinical manufacturing by reviewing documents and/or using technical expertise to ensure successful manufacturing campaigns.
  • Author electronic notebook records, process descriptions, process development reports, and other documentation/technical reports for progression of assets and/or support of regulatory filings.

Qualifications & Experience:

  • PhD in Biotechnology, Protein Chemistry, Biochemistry or Chemical/Biochemical Engineering, with 0-2 years, or MS with 2-4 years, or BS with 5-7 years of relevant industrial and/or academic experience preferred.
  • Hands-on experience with downstream bioprocessing unit operations, including chromatography (e.g., affinity, ion exchange, HIC) OR membrane-based separations (e.g., UF/DF, depth filtration), is required.
  • Knowledge of protein purification, protein stability, and demonstrated experimental skills for laboratory work are required.
  • Knowledge of protein characterization and analytical techniques is preferred.
  • Knowledge of statistical experimental design and data analysis is preferred.
  • Critical qualities include a high degree of initiative, good verbal and written communication skills, strong scientific skills and attention to detail, and the ability to work collaboratively in a team environment.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Devens - MA - US: $103,080 - $124,908

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

  • Health Coverage: Medical, pharmacy, dental, and vision care.

  • Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

  • Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

Work-life benefits include:

Paid Time Off

  • US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

  • Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.

R1601773 : Scientist, Downstream Process Development