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Downstream Purification Jobs (NOW HIRING)

247Hire

Process Engineer

Raleigh, NC · On-site

$170.48 - $242.80/hr

The facility will includefive 10,000 L bioreactorsandone downstream purification train, covering both upstream and downstream operations. The ANC2 project is currently in theequipment design phase.

New

Biogen

NC · On-site

$33.17 - $43.27/hr

This role's primary focus is Downstream (Purification): * Column Chromatography * Viral Filtration * Ultra-Filtration * Bulk Dispensing of the drug substance What You'll Do * Execute daily ...

Biogen

NC · On-site

$31.25 - $40.87/hr

This role's primary focus is Downstream (Purification): * Column Chromatography * Viral Filtration * Ultra-Filtration * Bulk Dispensing of the drug substance What You'll Do * Execute daily ...

Lonza

Biotechnologist I

Portsmouth, NH · On-site

$15.25 - $19.25/hr

Working in a GMP manufacturing environment, you will operate production equipment, execute downstream purification processes, and ensure products are manufactured safely and to the highest quality ...

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Downstream Purification information

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How much do downstream purification jobs pay per hour?

As of Sep 3, 2026, the average hourly pay for downstream purification in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are some common challenges faced in a downstream purification role, and how can they be addressed?

Professionals in Downstream Purification often encounter challenges such as maintaining product yield and purity, troubleshooting equipment malfunctions, and adapting to process variability. Addressing these requires strong analytical skills, attention to detail, and close collaboration with upstream teams and quality assurance. Continuous training on the latest purification technologies and strict adherence to standard operating procedures also help minimize errors and improve efficiency in the production process.

What are the key skills and qualifications needed to thrive in downstream purification, and why are they important?

To excel in Downstream Purification, you need a solid background in biochemistry or chemical engineering, with experience in protein purification techniques and a relevant degree. Familiarity with chromatography systems (e.g., AKTA), filtration technologies, and good manufacturing practice (GMP) certification is highly valuable. Strong analytical thinking, attention to detail, and effective teamwork are important soft skills in this role. These competencies ensure the efficient and reliable production of high-purity biopharmaceutical products, critical for product quality and regulatory compliance.

What is the difference between Downstream Purification vs Downstream Processing?

AspectDownstream PurificationDownstream Processing
FocusPurifying specific products from a mixtureOverall process including purification and initial recovery
CredentialsTypically requires bioprocessing or biotech certificationsSimilar credentials, often overlapping
Work EnvironmentLaboratories, clean rooms, manufacturing facilitiesLabs and production plants
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical, and bioprocessing industries

Downstream Purification is a specialized part of the broader Downstream Processing. While downstream processing includes all steps from initial product recovery to purification, downstream purification specifically focuses on isolating and purifying the target product. Both roles often require similar skills and certifications, and they operate in comparable environments within biotech and pharmaceutical industries.

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What states have the most Downstream Purification jobs?

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Downstream Purification jobs near you
Infographic showing various Downstream Purification job openings in the United States as of August 2026, with employment types broken down into 93% Full Time, 1% Part Time, 5% Contract, and 1% Nights. Highlights an 80% Physical, 5% Hybrid, and 15% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Manufacturing Associate II, Downstream

Tanvex BioPharma Inc

San Diego, CA • On-site

$66K - $78K/yr

Full-time

Posted 23 days ago

Job description

Under general supervision, the Manufacturing Associate II, Downstream, will perform routine manufacturing activities in GMP manufacturing areas including purification and the associated sub-processes/ preparation. Operations will be performed according to Standard Operating Procedures (SOPs) and batch records. Perform manufacturing steps, execute routine batch records, and revise documents such as batch records and SOPs as needed. Flexible shift schedule and overtime may be required.
Technical:
  • Perform tasks using defined protocols or procedures which contribute to the achievement of project milestones.
  • Perform GMP manufacturing activities in assigned areas.
  • Set-up, operate, maintain and clean downstream bioprocessing equipment, which includes but is not limited to chromatography systems, UF/DF and Viral filtration skids and mixers.
  • Perform basic troubleshooting of bioprocess equipment.
  • Perform manual cleaning and sterilization of manufacturing areas, parts and components.

Compliance:
  • Follow Standard Operating Procedures (SOPs), current Good Manufacturing Practices (cGMPs), plant safety guidelines and other established procedures during the manufacturing process to produce quality products.
  • Accurately complete and maintain detail-oriented process-related documentation of equipment logs and batch records following the manufacturing Good Documentation Practices (GDP).
  • Draft and revise SOPs and batch records.

Teamwork and Communication:
  • Participate in regularly scheduled team meetings to discuss ideas, troubleshoot issues, go over lessons learned and identify future projects or tasks.
  • Address production issues and report any compliance related concerns to supervisor and/or management as soon as possible.
  • Fosters teamwork and is expected to suggest project improvements

Requirements
Education and Experience
  • Advanced degree in life sciences or related discipline with 0 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.
  • Bachelor's degree with 3 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.
  • High School Diploma/GED with 6 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.

Knowledge, Skills and Abilities:
  • Downstream/Purification experience and skills in Protein Chromatography, TFF, Depth Filtration, Viral Filtration, Bulk Drug Substance Formulation, and Final Filtration. Aseptic Sampling of process pools and buffers. Buffer Preparation, Tubing assemblies and Autoclaving Operations.
  • Knowledge of UNICORN and Common Control Platform (CCP) Software is preferred.
  • Fundamental knowledge of current biologics regulations and cGMP for drug substance operation.
  • Proficient with Microsoft Word and Excel.
  • Able to work with pressurized systems, steam, and corrosive chemicals with necessary safety precautions.
  • Demonstrated ability to follow and document activities in written procedures and/or logbooks.
  • Detail-oriented, strong team player.
  • Effective collaboration skills and the ability to work cross functionally across categories and internal stakeholders.

Salary Description
$66,421 - $78,044

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