ZipRecruiter

Log In

1

Downstream Purification Jobs in Raleigh, NC (NOW HIRING)

Astrix Inc

Manufacturing Associate

Cary, NC · On-site

Perform downstream purification using AKTA chromatography systems. * Monitor process parameters and ensure compliance with SOPs and quality standards. * Support batch documentation and data recording.

Amgen

Sr Engineer I

Holly Springs, NC · On-site

$90K - $124K/yr

Provide technical leadership in Downstream (Purification) Bioprocessing for process monitoring, optimization, yield improvement, complex investigation, and product life cycle management * Partner ...

MSCCN

Sr Engineer I - Holly Springs, NC

Holly Springs, NC · On-site

$100K/yr

Support technology transfer, process validation, and plant start-up Provide technical leadership in Downstream (Purification) Bioprocessing for process monitoring, optimization, yield improvement ...

next page

Showing results 1-20

All JobsDownstream Purification JobsDownstream Purification Jobs in Raleigh, NC

Downstream Purification information

See Raleigh, NC salary details

$13

$24

$33

How much do downstream purification jobs pay per hour?

As of Jul 17, 2026, the average hourly pay for downstream purification in Raleigh, NC is $24.25, according to ZipRecruiter salary data. Most workers in this role earn between $19.62 and $28.03 per hour, depending on experience, location, and employer.

What is downstream purification?

Downstream purification is a process in biopharmaceutical manufacturing that involves isolating and refining a target product, such as a protein or antibody, from a mixture of cells, media, and other impurities. It typically includes steps like filtration, chromatography, and concentration to ensure product purity and quality. Downstream purification requires attention to detail, proper use of equipment, and adherence to regulatory standards.

What is the highest paying job in biotechnology?

In biotechnology, senior roles such as Biotech Executive, Director of Research, or Vice President of Biotechnology tend to be the highest paying positions, often earning six-figure salaries. These roles typically require advanced degrees, extensive experience, and leadership skills, with compensation influenced by company size and location.

What are the key skills and qualifications needed to thrive in Downstream Purification, and why are they important?

To excel in Downstream Purification, you need a solid background in biochemistry or chemical engineering, with experience in protein purification techniques and a relevant degree. Familiarity with chromatography systems (e.g., AKTA), filtration technologies, and good manufacturing practice (GMP) certification is highly valuable. Strong analytical thinking, attention to detail, and effective teamwork are important soft skills in this role. These competencies ensure the efficient and reliable production of high-purity biopharmaceutical products, critical for product quality and regulatory compliance.

What are some common challenges faced in a Downstream Purification role, and how can they be addressed?

Professionals in Downstream Purification often encounter challenges such as maintaining product yield and purity, troubleshooting equipment malfunctions, and adapting to process variability. Addressing these requires strong analytical skills, attention to detail, and close collaboration with upstream teams and quality assurance. Continuous training on the latest purification technologies and strict adherence to standard operating procedures also help minimize errors and improve efficiency in the production process.

What is the difference between Downstream Purification vs Downstream Processing?

AspectDownstream PurificationDownstream Processing
FocusPurifying specific products from a mixtureOverall process including purification and initial recovery
CredentialsTypically requires bioprocessing or biotech certificationsSimilar credentials, often overlapping
Work EnvironmentLaboratories, clean rooms, manufacturing facilitiesLabs and production plants
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical, and bioprocessing industries

Downstream Purification is a specialized part of the broader Downstream Processing. While downstream processing includes all steps from initial product recovery to purification, downstream purification specifically focuses on isolating and purifying the target product. Both roles often require similar skills and certifications, and they operate in comparable environments within biotech and pharmaceutical industries.

Is it hard to get a job in biotechnology?

Getting a job in downstream purification within biotechnology can be competitive, often requiring relevant education such as a degree in biochemistry, chemical engineering, or related fields, along with laboratory skills and experience with purification techniques like chromatography. Entry-level positions may be accessible with proper training, but advanced roles typically demand specialized knowledge and certifications. Strong understanding of Good Manufacturing Practices (GMP) and familiarity with bioprocessing tools can improve job prospects.

What biology jobs pay over $100k?

In the field of downstream purification, senior roles such as Process Development Managers, Regulatory Affairs Directors, and Senior Bioprocess Engineers often have salaries exceeding $100,000 annually. These positions typically require advanced degrees, extensive industry experience, and expertise in bioprocessing, quality control, or regulatory compliance.
What are popular job titles related to Downstream Purification jobs in Raleigh, NC? For Downstream Purification jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Downstream Purification jobs in Raleigh, NC look for? The top searched job categories for Downstream Purification jobs in Raleigh, NC are:
Downstream Purification jobs near you
Infographic showing various Downstream Purification job openings in Raleigh, NC as of July 2026, with employment types broken down into 100% Full Time. Highlights an 60% In-person, and 40% Remote job distribution, with an average salary of $50,441 per year, or $24.3 per hour.
Senior AssociateManufacturing-Bulk Drug Substance Downstream-Nights

Senior AssociateManufacturing-Bulk Drug Substance Downstream-Nights

Amgen

Holly Springs, NC

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 8 days ago

Job description

Career CategoryManufacturingJob Description

HOW MIGHT YOU DEFY IMAGINATION?

You'veworked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills,experience,and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over10 million patientsworldwide. Come do your bestworkalongside other innovative, driven professionals in this meaningful role.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the AmgenFleXBatch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. TheFleXBatch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

Senior AssociateManufacturing-Bulk Drug Substance Downstream-Nights

Live

What youwill do

Let'sdo this.Let'schange the world. In this dynamic role,you will beaSenior Associate inthemanufacturing organization atAmgenNorth Carolina (ANC).The essential position, which supports our critical 24/7 manufacturing operations,worksa 12-hour 2-2-3 schedule from 5:45pmto6:15am.Associates will beexecutingoperations on the floorin our downstreamareaandwillberesponsible forthe manufacturing of cGMP (Current Good Manufacturing Practices) drug substances.

With general direction, the Senior Associateis responsible forexecuting on-the-floor operations within manufacturingin accordance withcGMP practices.As Amgen relies upon the regular attendance of staff members to meet legitimate business needs, staff must be able to work assigned 12-hourshift, including during inclement weather, some holidays and requested overtime in support of our 24/7 operations.

Responsibilitieswill include...

Compliance:

  • Completes workin accordance withestablished cGMP procedures and policies (Standard Operating Procedures [SOPs], Manufacturing Procedures [MPs], Job Hazard Analysis [JHAs], Code of Federal Regulations [CFR]) with strict adherence to safety and compliance

  • Initiate quality non-conformance (NC) reports

  • Interact with regulatory agencies asneeded andguided

  • Assure proper gowning and aseptic techniques arealways followed

Process/Equipment/Facilities:

  • Understanding of downstream purification operation (Column Chromatography, TFF, Viral Filtration, Viral Inactivation)

  • Perform hands-ondownstream biotechoperations(Column Chromatography, Tangential Flow Filtration, Viral Filtration, Viral Inactivation, Column Packing among others)including set-up,operation,cleaning, sanitization,monitoringof equipment and assigned area

  • Runandmonitorcritical process tasksperassigned procedures

  • Perform in-process sampling,operateanalytical equipment, andcompleteprocess documentation(ElectronicBatchRecords[EBR])

  • Completewashroom activities:cleaning equipment, small to large scale, used in production activities

  • Initiate and own manufacturing relatedprocessdeviations

  • Identify, recommend, and implement innovative process improvements and optimizations related to daily routine functions

  • Assistin the review ofdocumentation for assigned functions (i.e.,equipment logs,EBRs)

  • Collaborateas part of across-functional team (i.e.,QA/QC,F&E (Facilities & Engineering), PPIC,Mfg.,PD (Process Development), Regulatory, etc.) in completing production activities

  • Responsible forrecognizing andelevating problems during daily operations

  • Participate in the implementation of programs and CAPAs (Corrective Action Preventive Action) with an eye toward continuous improvement

  • Drive safety in all operations, andassistthe manager in escalating concerns as needed

  • Maintain an organized, clean, and workable space

Administrative:

  • Draft and revise documents (SOPs, technical reports, and MPs)

  • Interacts with managementas an advisorin planningandinescalatingpotential concerns withtheschedule and/or process

Win

What we expectofyou

We are all different, yet we all use our unique contributions to serve patients. The hard-working professional weseekis ateam player with these qualifications.

Basic Qualifications:

  • HighSchoolDiploma/GED + 4yearsmanufacturing and/orotherregulatedenvironmentexperience

Or

  • Associate'sDegree+ 2 yearsmanufacturing and/orotherregulated environment experience

Or

  • Bachelor'sDegree+ 6 monthsmanufacturing and/orotherregulatedenvironmentexperience

Or

  • Master'sDegree

Preferred Qualifications:

  • Completion of NCBioWorksCertification Program

  • Experience in biotechnology or pharmaceuticalplant start up

  • Knowledge andprocessexperience within a cGMP manufacturingfacility or other highlyregulated environment

  • Understanding of downstream purification operation (Column Chromatography, TFF, Viral Filtration, Viral Inactivation)

  • Excellent verbal and written communication(technical) skills

  • Proficient Microsoft Office skills, and knowledge of other electronic systems such as EBR/MES, Delta V, and Electronic Quality Systems

Thrive

What you can expectofus

As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plancomprisinghealth and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

#AmgenNorthCarolina

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities areprovidedreasonable accommodation toparticipatein the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

.

Salary Range

86,048.05USD -116,417.95USD

Apply