ZipRecruiter

Log In

1

Downstream Purification Jobs (NOW HIRING)

AMRESCO

Associate Scientist - Downstream

Bridgewater, NJ

$69K - $110.98K/yr

Executes and supports downstream purification (e.g. monoclonal antibodies, fusion proteins, etc.) on a bench-scale jointly with other scientists or independently. * Conducts pilot-scale material ...

next page

Showing results 1-20

People also search for

All JobsDownstream Purification Jobs

Downstream Purification information

See salary details

$13

$24

$34

How much do downstream purification jobs pay per hour?

As of May 31, 2026, the average hourly pay for downstream purification in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Downstream Purification, and why are they important?

To excel in Downstream Purification, you need a solid background in biochemistry or chemical engineering, with experience in protein purification techniques and a relevant degree. Familiarity with chromatography systems (e.g., AKTA), filtration technologies, and good manufacturing practice (GMP) certification is highly valuable. Strong analytical thinking, attention to detail, and effective teamwork are important soft skills in this role. These competencies ensure the efficient and reliable production of high-purity biopharmaceutical products, critical for product quality and regulatory compliance.

What are some common challenges faced in a Downstream Purification role, and how can they be addressed?

Professionals in Downstream Purification often encounter challenges such as maintaining product yield and purity, troubleshooting equipment malfunctions, and adapting to process variability. Addressing these requires strong analytical skills, attention to detail, and close collaboration with upstream teams and quality assurance. Continuous training on the latest purification technologies and strict adherence to standard operating procedures also help minimize errors and improve efficiency in the production process.

What is downstream purification?

Downstream purification refers to the series of processes used to isolate and purify a target product, such as a protein or antibody, from a complex mixture after it has been produced by cells or microorganisms. This is a critical step in biotechnology and pharmaceutical manufacturing, involving techniques like filtration, chromatography, and centrifugation to remove impurities and contaminants. The goal is to achieve a high level of purity and quality for the final product, ensuring it meets regulatory standards for use in research, diagnostics, or therapeutics.

What is the difference between Downstream Purification vs Downstream Processing?

AspectDownstream PurificationDownstream Processing
FocusPurifying specific products from a mixtureOverall process including purification and initial recovery
CredentialsTypically requires bioprocessing or biotech certificationsSimilar credentials, often overlapping
Work EnvironmentLaboratories, clean rooms, manufacturing facilitiesLabs and production plants
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical, and bioprocessing industries

Downstream Purification is a specialized part of the broader Downstream Processing. While downstream processing includes all steps from initial product recovery to purification, downstream purification specifically focuses on isolating and purifying the target product. Both roles often require similar skills and certifications, and they operate in comparable environments within biotech and pharmaceutical industries.

More about Downstream Purification jobs
What cities are hiring for Downstream Purification jobs? Cities with the most Downstream Purification job openings:
What states have the most Downstream Purification jobs? States with the most job openings for Downstream Purification jobs include:
What job categories do people searching Downstream Purification jobs look for? The top searched job categories for Downstream Purification jobs are:
Downstream Purification jobs near you
Infographic showing various Downstream Purification job openings in the United States as of May 2026, with employment types broken down into 82% Full Time, 12% Part Time, 1% Temporary, and 5% Contract. Highlights an 57% Physical, 10% Hybrid, and 33% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Downstream Purification Scientist

Globalchannelmanagement

Boston, MA

$46 - $47/hr

Full-time

Posted 20 days ago

Job description

Downstream Purification Scientist needs 2 years of hands-on purification experience in an academic or industry setting

Downstream Purification Scientist requires:

  • Hands-on experience in Cesium chloride (CsCl) density gradient ultracentrifugation, ion-exchange chromatography, affinity purification, and tangential flow filtration (TFF), with a strong understanding of purification principles and data analysis.
  • Master's degree in biology, biochemistry, chemical engineering, biotechnology, or related field.
  • AAV or other viral vector CsCl density gradient and column purification.
  • Experience with AKTA systems and Unicorn software.

Downstream Purification Scientist duties:

  • Execute purification processes including CsCl density gradient ultracentrifugation, affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and other polishing steps.
  • Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs. Perform TFF operations for buffer exchange and concentration of intermediate or final products.
  • Support experimental design, data collection, and documentation following established procedures and GMP/GLP best practices.
  • Assist in troubleshooting and optimization of purification processes.
  • Analyze in-process and purified samples using relevant analytical methods (e.g., UV, SDS-PAGE, ddPCR, ELISA, or HPLC).
  • Collaborate cross-functionally with upstream, analytical, and manufacturing teams.
  • Maintain lab equipment, manage buffers and column inventory, and ensure compliance with safety and documentation standards.