ZipRecruiter

Log In

1

Downstream Purification Jobs (NOW HIRING)

next page

Showing results 1-20

All JobsScience JobsBiology JobsBiologist JobsDownstream Purification Jobs

Downstream Purification information

See salary details

$13

$24

$34

How much do downstream purification jobs pay per hour?

As of Sep 3, 2026, the average hourly pay for downstream purification in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are some common challenges faced in a downstream purification role, and how can they be addressed?

Professionals in Downstream Purification often encounter challenges such as maintaining product yield and purity, troubleshooting equipment malfunctions, and adapting to process variability. Addressing these requires strong analytical skills, attention to detail, and close collaboration with upstream teams and quality assurance. Continuous training on the latest purification technologies and strict adherence to standard operating procedures also help minimize errors and improve efficiency in the production process.

What are the key skills and qualifications needed to thrive in downstream purification, and why are they important?

To excel in Downstream Purification, you need a solid background in biochemistry or chemical engineering, with experience in protein purification techniques and a relevant degree. Familiarity with chromatography systems (e.g., AKTA), filtration technologies, and good manufacturing practice (GMP) certification is highly valuable. Strong analytical thinking, attention to detail, and effective teamwork are important soft skills in this role. These competencies ensure the efficient and reliable production of high-purity biopharmaceutical products, critical for product quality and regulatory compliance.

What is the difference between Downstream Purification vs Downstream Processing?

AspectDownstream PurificationDownstream Processing
FocusPurifying specific products from a mixtureOverall process including purification and initial recovery
CredentialsTypically requires bioprocessing or biotech certificationsSimilar credentials, often overlapping
Work EnvironmentLaboratories, clean rooms, manufacturing facilitiesLabs and production plants
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical, and bioprocessing industries

Downstream Purification is a specialized part of the broader Downstream Processing. While downstream processing includes all steps from initial product recovery to purification, downstream purification specifically focuses on isolating and purifying the target product. Both roles often require similar skills and certifications, and they operate in comparable environments within biotech and pharmaceutical industries.

More about Downstream Purification jobs

What cities are hiring for Downstream Purification jobs?

Cities with the most Downstream Purification job openings:

What states have the most Downstream Purification jobs?

States with the most job openings for Downstream Purification jobs include:

What job categories do people searching Downstream Purification jobs look for?

The top searched job categories for Downstream Purification jobs are:

Downstream Purification jobs near you
Infographic showing various Downstream Purification job openings in the United States as of August 2026, with employment types broken down into 93% Full Time, 1% Part Time, 5% Contract, and 1% Nights. Highlights an 80% Physical, 5% Hybrid, and 15% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Process Engineer, Downstream Purification and Chemical Synthesis

LAMP

Liberty, TX • On-site

Full-time

Posted 7 days ago

Job description

Position Purpose

Owns everything after the fermenter, including broth clarification, purification, the catalytic conversion step and final product purification to specification.

Key Responsibilities

  • Own the downstream process description covering separation, filtration, ion exchange or chromatography, crystallization, drying and solvent recovery.
  • Own the catalytic conversion step, including fixed bed reactor operation, catalyst loading and unloading, activity monitoring and regeneration or replacement planning.
  • Own distillation and purification operations and the product specification control strategy.
  • Translate the process into operating procedures, control narratives and operator training content.
  • Track yield, recovery, purity and solvent losses at each step and drive improvement.
  • Manage polymerization risk, including inhibitor dosing, oxygen requirement and temperature limits, alongside the process safety engineer.
  • Support commissioning of downstream and reaction systems, including catalyst first load and performance verification.
  • Interface with the technology partner and catalyst supplier on performance questions.

Required Qualifications

  • Bachelor's or master's degree in chemical engineering or organic chemistry with process experience.
  • Five or more years in downstream purification or organic chemical synthesis at production scale.
  • Direct experience with separation, crystallization or distillation unit operations.
  • Solvent handling and recovery experience.

Preferred Qualifications

  • Fixed bed catalytic reactor operating experience.
  • Reactive monomer experience.
  • Chromatography or ion exchange purification at scale.