ZipRecruiter

Log In

1

Downstream Engineer Jobs (NOW HIRING)

Legend Biotech USA, Inc.

Legend Biotech is seeking a Principal Engineer, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.Role OverviewThe Principal Engineer ...

previous pagenext page

Showing results 21-40

All JobsManufacturing JobsProduct Manufacturing JobsProcess Engineer JobsDownstream Engineer Jobs

Downstream Engineer information

See salary details

$36.5K

$107.3K

$137.5K

How much do downstream engineer jobs pay per year?

As of Aug 23, 2026, the average yearly pay for downstream engineer in the United States is $107,282.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,500.00 and $136,000.00 per year, depending on experience, location, and employer.

What is a downstream engineer?

Downstream Engineers are professionals who work in the downstream sector of the oil and gas industry, which involves the refining of crude oil, processing of raw natural gas, and the distribution and marketing of petroleum products. They are responsible for designing, operating, and optimizing processes in refineries and petrochemical plants to ensure efficient and safe production. Downstream Engineers also work on improving product quality, reducing environmental impact, and troubleshooting operational issues. Their roles often require strong knowledge of chemical engineering, process optimization, and safety regulations.

What are some common challenges faced by downstream engineers when optimizing refinery processes?

Downstream Engineers often face the challenge of balancing efficiency, safety, and environmental compliance while optimizing refinery processes. They must troubleshoot complex systems, identify bottlenecks, and implement solutions that maximize yield without compromising product quality or safety standards. Additionally, adapting to evolving regulations and integrating new technologies, such as digital process control systems, requires continuous learning and collaboration with multidisciplinary teams. These challenges make the role dynamic and rewarding for engineers who enjoy problem-solving and innovation.

What are the key skills and qualifications needed to thrive as a downstream engineer, and why are they important?

To thrive as a Downstream Engineer, you need a solid background in chemical or petroleum engineering, process optimization, and industrial safety, usually supported by a relevant engineering degree. Familiarity with process simulation software (like Aspen HYSYS or ChemCAD), industry standards, and certifications such as Professional Engineer (PE) are typically required. Strong analytical thinking, problem-solving, and effective communication skills help you collaborate with multidisciplinary teams and address operational challenges. These skills and qualifications are vital for ensuring safe, efficient, and compliant operation of refining and petrochemical processes.

What are the most commonly searched types of Downstream Engineer jobs?

The most popular types of Downstream Engineer jobs are:

What states have the most Downstream Engineer jobs?

States with the most job openings for Downstream Engineer jobs include:

Downstream Engineer jobs near you
Infographic showing various Downstream Engineer job openings in the United States as of August 2026, with employment types broken down into 94% Full Time, 2% Part Time, and 4% Contract. Highlights an 85% Physical, 6% Hybrid, and 9% Remote job distribution, with an average salary of $107,282 per year, or $51.6 per hour.

Principal Engineer, Lentivirus Downstream Process Development

Legend Biotech US

Somerset, NJ

Full-time

Posted 24 days ago

Job description

Legend Biotech is seeking a Principal Engineer, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Engineer, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our
innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)-including clarification, chromatography, TFF, sterile filtration and fill/finish-ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
  • Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
  • Provide hands-on training as needed.
  • Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs.
  • Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
  • Communicate the potential for issues and delays along with solutions and mitigation approaches.
  • In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
  • Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
  • Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
  • Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
  • Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
  • Tech transfer process to/from other Legend sites or CDMOs.
  • Resolve conflict and proactively identify/address performance issues.
  • Ensure compliance with regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, bioprocessing engineering or a related field.
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
  • Strong engineering knowledge of the principles of scaledown model and the interaction of biomolecules, materials and machinery.
  • Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred).
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field.
  • Ability to implement closed-system processes and maximize cost effectiveness.
  • Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
  • Creative, strategic thinking.
  • Strong troubleshooting skills.
  • Preferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery.
  • Preferred experience in handling large scale(>50L) purification process.

#Li-JR1

#Li-Onsite

Apply