Director Supply Chain Jobs (NOW HIRING)

Position Title: Director, Supply Chain – Location: Princeton (Hybrid) – Reports To: SVP, Drug Discovery and CMC

PMV Pharma is pioneering the development of first‑in‑class p53 regulators for cancer treatment. By bringing together leaders in the field and leveraging over three decades of p53 biology research, PMV Pharma integrates unique biological insights with a strong focus on pharmaceutical development.

We are seeking an experienced Director of Supply Chain to lead end‑to‑end supply chain strategy and execution for a prescription drug, preparing for its first commercial launch. The role will build and manage all supply chain capabilities required to transition from clinical to commercial supply, including demand planning, S&OP, direct oversight and execution of drug product manufacturing, packaging and labeling operations, external manufacturing and distribution readiness, CMO/CPO/3PL management, product release planning, and launch inventory management.

In this small biotech organization, the Director serves as the single‑threaded owner of finished drug product supply, from manufacturing through delivery to the market. The role requires both strategic leadership and hands‑on execution, working cross‑functionally with Technical, Quality, Regulatory, Finance, Commercial, and external partners to ensure launch readiness and ongoing commercial supply continuity.

• Develop and execute the end‑to‑end commercial supply chain strategy and launch readiness plan (manufacturing, packaging/labeling, distribution, logistics) to ensure uninterrupted supply.
• Lead demand forecasting, supply planning, inventory strategy (risk buffers), and scenario modeling to support decisions.
• Define and track supply chain KPIs and dashboards to drive performance and proactively manage risk.

• Own end‑to‑end drug product manufacturing for commercial supply (planning, campaign readiness, execution, and continuity).
• Serve as primary interface to drug product CMOs; align schedules, materials, yields, and release timing; partner with Technical and Quality on deviations and lot disposition.
• Manage tradeoffs across supply risk, inventory, cost, and timelines in a resource‑constrained environment.

• Lead commercial packaging and labeling operations end‑to‑end (CPOs, artwork readiness, serialization readiness, packaging execution).
• Manage label lifecycle (version control, change control, label inventory) to meet regulatory and distribution requirements and minimize obsolescence.

• Lead 3PL operations (warehousing, order fulfillment, distribution, returns, reconciliation) and ensure network readiness via SOPs, SLAs, and KPI monitoring.
• Oversee GDP compliance and import/export activities to enable compliant, reliable distribution.

• Build and run the S&OP process, integrating inputs from Commercial, Finance, Quality, and Operations to align demand, supply, and inventory.
• Develop demand forecasts; manage finished goods, WIP, and packaging inventory to support launch and ongoing supply while minimizing write‑offs and obsolescence.

• Own commercial change control; assess supply, inventory, and distribution impacts of CMC, labeling, site, and process changes.
• Partner with Technical, Quality, and Regulatory to implement post‑approval changes and lifecycle plans (alternate sites, process improvements, scale changes) while minimizing supply disruption.

• Own commercial lot release planning; align testing, documentation, disposition, and distribution release.
• Lead cross‑functional release readiness reviews; partner with Quality and Regulatory to support GMP/GDP compliance, serialization, and distribution requirements.

• Develop and maintain commercial COGS models with Finance/Technical; drive supply‑led cost improvements while maintaining compliance and reliability.
• Lead supply risk assessments and mitigation (safety stock, alternate sourcing); implement and improve supply chain systems (ERP, forecasting, inventory) and supporting SOPs.

• 10+ years of experience in pharmaceutical or biotech supply chain, including at least 5 years in a leadership role.
• Direct, hands‑on experience supporting the commercial launch of a prescription drug, including operational ownership of drug product manufacturing, packaging/labeling, and distribution.
• Strong understanding of GMP/GDP requirements and FDA regulatory expectations.
• Bachelor’s degree in supply chain, engineering, life sciences, operations, or equivalent professional certification.
• Experience managing CMOs, CPOs, and 3PLs in a regulated environment.

• Experience in small‑to‑mid‑size biotech companies transitioning from clinical to commercial stage.
• ERP or supply chain system implementation experience (e.g., NetSuite, SAP, Oracle).
• Serialization and track‑and‑trace experience.

• Strategic thinker with strong operational execution capability.
• Hands‑on leader comfortable wearing multiple hats.
• Skilled in risk management, scenario planning, and cross‑functional alignment.
• Clear, effective communicator with strong stakeholder‑management skills.
• Ability to build structure and discipline in an evolving organization.

The expected salary range for this position is $200,000 to $230,000, representing the potential low and high ends. Actual salaries may vary depending on factors such as experience, skillset, and performance.

The salary range listed is just one component of our total compensation package. PMV Pharma also provides a competitive suite of benefits, including health care benefits (medical, prescription drugs, dental, and vision insurance), paid parental leave benefits and adoption assistance, a generous Paid Time Off program, Employee Stock Purchase Plan, rewards and recognition program and much more.

PMV Pharmaceuticals is an Equal Opportunity Employer, and all applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.