Director Eli Lilly Rn Jobs (NOW HIRING)

Description of Role

Centessa is seeking an experiencedSenior Director, Clinical Pharmacologytoprovide scientific and strategic leadership for translationalclinical pharmacology across a diverse pipeline spanning early development throughlatestageand registrational programs.Reporting to the Executive Director, Clinical Pharmacology,this positionis accountable for developing and executing clinical pharmacology strategies that address the unique challenges of neuroscience drug development, including CNS exposure, dose optimization, and translational relevance. The Senior Director partners closely withcrossfunctionalteams, and cross-program teams to achieve broader translational understanding of our assets, and application of that knowledge to development programs. Additionally, they willrepresentclinical pharmacology in regulatory interactions to enable efficient,datadrivenadvancement of therapies across our neuroscience portfolio.

Key Responsibilities

• Lead strategy for collection and interpretation of information across in vitro, in vivo, literature of competitive sources, and clinical data to develop a translational knowledge base to Centessa assets

• Drive doseselectionand optimizationbyintegratingPK, PD, safety, efficacy, andCNSspecificbiomarkers

• Leadmodelinformeddrug development, including population PK, PK/PD, and exposure-response analyses relevant to CNS targetsand clinical safety

• Assess and guide strategies for CNS exposure, brain penetration, target engagement, and translational biomarkers

• Lead clinical pharmacology strategy for CNS and neuroscience programs fromfirstinhumanthrough registrational andpostmarketingstages

• Design, execute, and interpret clinical pharmacology studies, including FIH,multipleascendingdose, DDI, biopharmaceutics, and patient studies

• Serve as the clinical pharmacology lead on program teams, clinicalsubteams, and trial working groups

• Author and oversee clinical pharmacology sections of regulatory documents (e.g., INDs, CTAs, IBs, NDAs)

• Represent clinical pharmacology in interactions with FDA and other global health authorities, supporting dose justification and labeling discussions

• Partner closely with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs

• Oversee CROs and external vendorsconductingclinical pharmacology and modeling activities

• Ensuretimelycommunication and clear interpretation of clinical pharmacology results to internal stakeholders

• Contribute to portfolio strategy, program prioritization, risk mitigation, andlongrangeclinical development planning for CNS assets

• Serve as asubjectmatterexpert on clinical pharmacology

• Mentor and develop clinical pharmacology talent as the pipeline and organization grow

• Ensurehighquality,submissionreadydocumentation aligned with global regulatory standards

Qualifications

• PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline

• 10+ years of experience in clinical pharmacology within biopharma, withdemonstratedimpact intranslational science indrug development

• Strongexpertisein PK, PD, PK/PD integration, exposure-response analyses, and drug-drug interaction assessment

• Extensive experience developing and executing clinical pharmacology strategies for earlythroughlatestageprograms, including registrational support

• Demonstrated experience applying quantitative clinical pharmacologyand translationalapproaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization

• Proficiencywith clinical pharmacology tools and platforms such as NONMEM, R, PhoenixWinNonlin,SimCyp, or equivalent

• Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities

• Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development

• Excellent communication, collaboration, and leadership skills with the ability tooperateeffectively in afastpaced, matrixed environment

Work Location

The Senior Director, Clinical Pharmacology role is based in the US, with occasional travel.