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Director Clinical Operations Jobs in Colorado (NOW HIRING)

AMC Health

VP, Clinical Operations

Denver, CO · On-site

The VP will partner closely with Medical Directors, Product, Technology, Data Science, and Client Success teams to support program implementation, clinical workflow optimization, and operational ...

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Director Clinical Operations information

See Colorado salary details

$63.1K

$153.5K

$297.1K

How much do director clinical operations jobs pay per year?

As of Aug 22, 2026, the average yearly pay for director clinical operations in Colorado is $153,489.00, according to ZipRecruiter salary data. Most workers in this role earn between $107,300.00 and $182,400.00 per year, depending on experience, location, and employer.

What does a director of clinical operations do?

A director of clinical operations manages the daily operations of a healthcare facility or a specific department within a clinic or hospital. As a director of clinical operations, your responsibilities include scheduling staff to ensure proper coverage of patients and overseeing the productivity of your team to meet the organization's expectations. You define policies and procedures, facilitating further training when necessary. The director of clinical operations must also assess the performance of the medical team under your supervision regularly and mainstream processes when possible. Medical device manufacturers and pharmaceutical companies often hire a director of clinical operations to oversee research, lab, and testing operations.

What does a director of clinical operations do?

A Director of Clinical Operations is responsible for overseeing the day-to-day management and strategic direction of clinical trials and research activities within healthcare organizations or pharmaceutical companies. They ensure that clinical studies are conducted efficiently, ethically, and in compliance with regulatory requirements. This role involves supervising teams, managing budgets, developing protocols, and liaising with stakeholders to ensure successful trial outcomes. Directors of Clinical Operations play a crucial role in bringing new medical treatments to market by ensuring studies run smoothly from start to finish.

What are the key skills and qualifications needed to thrive as a director of clinical operations?

To thrive as a Director of Clinical Operations, you need a robust background in clinical management, regulatory compliance, and healthcare administration, often supported by a relevant degree and substantial leadership experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications like PMP or CCRA are commonly required. Exceptional leadership, strategic thinking, and communication skills help drive teams, manage stakeholders, and oversee complex projects. These skills are critical for ensuring clinical programs run efficiently, meet regulatory standards, and deliver high-quality patient outcomes.

How does a director of clinical operations typically collaborate with cross-functional teams to ensure successful clinical trial execution?

A Director of Clinical Operations regularly collaborates with cross-functional teams such as regulatory affairs, data management, medical affairs, and biostatistics to ensure clinical trials are executed on time, within budget, and in compliance with regulations. This role involves leading team meetings, aligning project timelines, and facilitating communication between internal stakeholders and external partners like CROs and vendors. Strong coordination skills are essential, as the Director must balance diverse priorities and resolve any operational issues that arise, ensuring all teams work toward shared objectives.

What is the difference between Director Clinical Operations vs Clinical Project Manager?

AspectDirector Clinical OperationsClinical Project Manager
CredentialsTypically requires advanced degrees (e.g., MS, PhD) and extensive industry experienceUsually holds a bachelor's or master's degree in a related field, with relevant project management certifications
Work EnvironmentOversees multiple projects and teams across departments, strategic planningManages individual clinical trials, coordinates project activities, and timelines
Employer & Industry UsageUsed in pharmaceutical, biotech, and healthcare companies for senior leadership rolesCommonly employed in clinical research organizations and pharmaceutical companies for trial management

The main difference is that the Director Clinical Operations focuses on strategic oversight and leadership across multiple clinical trials, while the Clinical Project Manager handles the day-to-day management of specific clinical studies. Both roles require strong industry knowledge, but the director position involves broader responsibilities and higher-level decision-making.

Is a director of clinical operations a high position?

A director of clinical operations is a senior leadership role responsible for overseeing clinical trial activities, managing teams, and ensuring regulatory compliance. It is considered a high-level position within the healthcare and pharmaceutical industries, often requiring extensive experience and strategic skills.
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What cities in Colorado are hiring for Director Clinical Operations jobs?

Cities in Colorado with the most Director Clinical Operations job openings:

Director Clinical Operations jobs near you
Infographic showing various Director Clinical Operations job openings in Colorado as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 11% Part Time, 2% Temporary, 2% Contract, and 1% Nights. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution, with an average salary of $153,489 per year, or $73.8 per hour.

Associate Director, Clinical Operations

EDGEWISE Therapeutics, Inc.

Boulder, CO • On-site

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 17 days ago

Job description

When you join the Edgewise team, you become part of something bigger: a group of people dedicated to new advances in cardiovascular science, committed to improving the lives of people and families facing the challenges of serious cardiovascular diseases.

Our ability to succeed depends on a cross-functional team embracing our core values.

Connection

We connect with patients and families to better understand their experience and needs which help guide our plans. We connect with our team to foster our unique skills and abilities. We treat each other with respect and embrace diversity.

We are intensely focused on our mission to invent medicines that truly make a difference for patients. We excel within our core competencies and understand the value our role brings to the team. We leverage the collective knowledge and skills of our team and external experts to achieve our goals.

Courage

We are charting a new course. We learn from the patients we serve – their tenacity and courage fuel our passion. We are driven by our urgent need for innovative therapies. We support final decisions and move forward as a team. We celebrate successes, embrace failures and continuously learn.

We are proud to offer excellent benefits to our team.

We provide comprehensive insurance including robust medical, dental, vision, and life and disability coverage for you and yourfamily.

We offer market competitive compensation including competitive base salary and discretionary bonus; opportunities for company ownership via stock option grants and an employee stock purchase plan; and a competitive 401(k) plan, complete with company matching.

Work Life Balance

Flexible scheduling: Many of our positions have flexibility built in. Whether this be work hours or remote/hybrid work options, we understand the needs of today’s workforce. For our on‑site and research team, we offer lunches, healthy snacks and a beautiful work environment. We believe that our team does their best work and thrives when they have balance in their lives.

Generous Paid Time Off: Take advantage of our generous PTO policy, including vacation days, sick leave, paid holidays, and annual company shut‑down.

Professional Growth Continued Learning

We encourage development with access to training programs, workshops, and professional certifications. We also have a robust tuition reimbursement program.

Bolder in Boulder &Beyond

We’re changing the landscape of cardiovascular muscle disease in one of the world’s most beautiful settings: Boulder Colorado and around the world.

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