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Contract Clinical Trial Manager Jobs (NOW HIRING)

C4 Therapeutics Inc

Clinical Trial Manager

Watertown, MA · On-site

$138K - $153K/yr

In collaboration with the Clinical Operations leadership, develop, manage, and track clinical trial budgets including providing ongoing reporting and forecasting to finance (inclusive of site budget ...

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Kymera Therapeutics

Clinical Trial Manager

Watertown, MA · On-site

$115K - $200K/yr

... other contract personnel. * Manage study timelines and metrics to ensure completion of study ... Review and analyze clinical trial data to identify trends and potential issues. * Ensure tracking ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · On-site

$120K - $150K/yr

Frontier Medicines is seeking two Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · Hybrid

$120K - $150K/yr

Frontier Medicines is seeking two Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance ...

Kymera Therapeutics

Clinical Trial Manager

Watertown, MA · On-site

$115K - $200K/yr

... other contract personnel. * Manage study timelines and metrics to ensure completion of study ... Review and analyze clinical trial data to identify trends and potential issues. * Ensure tracking ...

TransMedics

Clinical Trial Manager

Andover, MA

Manage clinical site interactions (including assistance with IRB/EC applications, contract negotiations, enrollment tracking, clinical trial material and clinical supply requests, issue resolution ...

CareDx, Inc.

Clinical Trial Manager

Brisbane, CA · Remote

The Clinical Trial Manager (CTM) is responsible for the management of clinical trials from study ... Conduct internal review of investigator contracts and payments, as necessary. * Provide cross ...

Prometrika LLC

Clinical Trial Manager

Cambridge, MA · On-site

$140K - $168K/yr

Manage the feasibility, selection, training and evaluation of study personnel (contract and ... clinical trial operations * Demonstrated experience managing multiple studies, sites and vendors ...

Verastem

Clinical Trial Manager

Boston, MA

$100K - $125K/yr

Negotiate master service agreements, work orders, contracts, and amendments for sites/vendors ... Manager to discuss overall clinical trial(s) plans, update forecasting, and identify potential ...

TransMedics

Clinical Trial Manager

Andover, MA · On-site

Manage clinical site interactions (including assistance with IRB/EC applications, contract negotiations, enrollment tracking, clinical trial material and clinical supply requests, issue resolution ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · On-site

$120K - $150K/yr

Frontier Medicines is seeking two Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance ...

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How much do contract clinical trial manager jobs pay per hour?

As of Aug 8, 2026, the average hourly pay for contract clinical trial manager in the United States is $62.52, according to ZipRecruiter salary data. Most workers in this role earn between $50.72 and $70.43 per hour, depending on experience, location, and employer.

What is a contract clinical trial manager?

A Contract Clinical Trial Manager is a professional who oversees the planning, execution, and management of clinical trials for pharmaceutical, biotech, or medical device companies on a contractual basis. Unlike full-time employees, contract clinical trial managers are typically hired for specific projects or time periods to ensure compliance with regulatory requirements, manage study timelines, and coordinate with cross-functional teams. Their responsibilities include supervising site selection, budget management, and ensuring data quality and patient safety throughout the trial. They play a crucial role in bringing new treatments to market by ensuring trials are conducted efficiently and ethically.

What are the key skills and qualifications needed to thrive as a contract clinical trial manager?

To thrive as a Contract Clinical Trial Manager, you need expertise in clinical research processes, project management, regulatory compliance, and a degree in life sciences or related field. Familiarity with electronic data capture (EDC) systems, clinical trial management systems (CTMS), and certifications such as ACRP or SOCRA are commonly required. Excellent organizational skills, attention to detail, and strong communication enable effective coordination with sponsors, sites, and cross-functional teams. These skills ensure clinical trials meet regulatory standards, timelines, and quality benchmarks critical for successful drug development.

What is the difference between Contract Clinical Trial Manager vs Clinical Research Associate?

AspectContract Clinical Trial ManagerClinical Research Associate
CredentialsTypically requires a Bachelor's degree in life sciences, clinical research certification preferredUsually holds a Bachelor's degree in life sciences or related field, with some certifications
Work EnvironmentManages multiple trials, oversees teams, often works remotely or on-site at trial locationsMonitors clinical sites, ensures protocol compliance, works primarily on-site at trial locations
Employer & Industry UsageHired by pharmaceutical companies, CROs, or biotech firms for trial managementEmployed by sponsors or CROs to monitor and support clinical sites

The Contract Clinical Trial Manager focuses on overseeing entire clinical trials, managing teams, and ensuring trial milestones are met. In contrast, the Clinical Research Associate primarily monitors clinical sites to ensure compliance and data integrity. Both roles require similar educational backgrounds but differ in scope and responsibilities within the clinical research process.

What are some common challenges faced by contract clinical trial managers, and how can they be effectively addressed?

Contract Clinical Trial Managers often navigate challenges such as coordinating multiple stakeholders, adhering to tight timelines, and managing protocol deviations across diverse research sites. To address these, strong communication skills and proactive project management are essential. Developing clear processes for documentation, regular team check-ins, and maintaining flexibility help ensure that trials remain compliant and on schedule. Additionally, leveraging technology for real-time data tracking can streamline collaboration and issue resolution.
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Contract Clinical Trial Manager jobs near you
Infographic showing various Contract Clinical Trial Manager job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $130,034 per year, or $62.5 per hour.

Clinical Trial Manager

SAGIMET BIOSCIENCES INC.

San Mateo, CA

$90 - $100/hr

Full-time

Posted 24 days ago

Job description

Description

The Clinical Trial Manager manages and leads the day-to-day clinical trial activities related to the development and execution of cross-functional and third-party vendor activities and deliverables. Additional responsibilities include Independent oversight of outsourced clinical studies, protocol review for operational feasibility and consistency, CRO/vendor feasibility, request for proposal and bid defense process, country/site feasibility, tracking site selection, activation, and patient recruitment. The Clinical Trial Manager will also focus on the management of project timelines, relevant study plans (e.g. monitoring, study operations, quality, communications, etc.), EDC and IXRS set up and development and/or review of clinical data management conduct (e.g. eCRFs, CRF guidelines). 


 Essential Responsibilities:

 Clinical operations leader and main point of contact with counterpart at outside vendor, CRO and/or trial sites; daily review and identification of potential issues or problems and communicates/escalates to project team. 

Assist in the critical development and review of key study documents (e.g. Protocols, ICF, study plans eCRF, etc.). 

Develop, maintain and promote effective and collaborative working relationships with and among internal team members and external vendors and 3rd party personnel. 

Participate in Clinical Operations meetings as assigned.  

Lead reviews of key data to identify trends, discrepancies, errors etc. to ensure ongoing quality of conduct in accordance with the protocol and vendor contracts, including on-going review of emerging data for tables, listings, and figures. 

Work with junior CTM for oversight of in-house review of site monitoring reports and tracking to ensure appropriate monitoring of trial conduct and satisfactory resolution of outstanding issues. 

Work with junior CTM for oversight of Trial Master Files (TMF) oversight plan and laisses with CRO for annual quality check; ensuring tracking of ICH-GCP and/or FDA CRF21 essential study documents. 

Track patient and recruitment status using applicable spreadsheets and web portal tools. 

Assist in yearly IND updates including IBs and DSUR. 

Requirements

A minimum of a Bachelor's degree or equivalent is required, preferably in Life Sciences (e.g. Biology, Chemistry, Biochemistry, Nursing, Pharmacy) 

A minimum of ten years clinical operations experience 

A minimum of three years of experience leading clinical trials from start-up to database lock 

Experience with all three parts of leading a global Phase 2 and/or Phase 3 clinical trial: start up, treatment phase and database lock. 

Experience in start up and oversight of central lab, including depth specification review. 

Knowledge of sample collect and analysis process at the study level and may perform reconciliation and/or tracking of sample manifests. 

Experience with data privacy and GDPR guidelines.  

Experience with the independent management and oversight of CROs/vendors required. 

Experience with double blind/placebo controlled studies required. 

Experience within a small biotech organization and flexibility to pivot quickly and think outside the box. 

Excellent attention to detail, accuracy in work and possesses strong analytical skills. 

Must think critically and creatively and be able to work independently to determine appropriate actions to resolve complex problems. 

Comprehensive knowledge of FDA and/or EMEA Regulations, ICH Guidelines, and GCPs governing the conduct of clinical trials 

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