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Contract Clinical Trial Manager Jobs (NOW HIRING)

C4 Therapeutics Inc

Clinical Trial Manager

Watertown, MA · On-site

$138K - $153K/yr

In collaboration with the Clinical Operations leadership, develop, manage, and track clinical trial budgets including providing ongoing reporting and forecasting to finance (inclusive of site budget ...

Kymera Therapeutics

Clinical Trial Manager

Watertown, MA

$115K - $200K/yr

... other contract personnel. * Manage study timelines and metrics to ensure completion of study ... Review and analyze clinical trial data to identify trends and potential issues. * Ensure tracking ...

Frontier Medicines

Clinical Trial Manager

Boston, MA · Hybrid

$120K - $150K/yr

Frontier Medicines is seeking two Clinical Trial Managers to support the day-to-day execution of our oncology clinical trials as they advance through clinical development. Working under the guidance ...

Kymera Therapeutics

Clinical Trial Manager

Watertown, MA · On-site

$115K - $200K/yr

... other contract personnel. * Manage study timelines and metrics to ensure completion of study ... Review and analyze clinical trial data to identify trends and potential issues. * Ensure tracking ...

Prometrika LLC

Clinical Trial Manager

Cambridge, MA · On-site

$140K - $168K/yr

Manage the feasibility, selection, training and evaluation of study personnel (contract and ... clinical trial operations * Demonstrated experience managing multiple studies, sites and vendors ...

Ocugen Inc

Clinical Trial Manager

Malvern, PA · On-site

Position Summary The Clinical Trial Manager (CTM) is responsible for the overall operational management and execution of clinical trials from initiation through close-out. This includes leading the ...

OCUGEN OPCO INC

Clinical Trial Manager

Malvern, PA · On-site

Position Summary The Clinical Trial Manager (CTM) is responsible for the overall operational management and execution of clinical trials from initiation through close-out. This includes leading the ...

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How much do contract clinical trial manager jobs pay per hour?

As of Sep 3, 2026, the average hourly pay for contract clinical trial manager in the United States is $62.52, according to ZipRecruiter salary data. Most workers in this role earn between $50.72 and $70.43 per hour, depending on experience, location, and employer.

What is a contract clinical trial manager?

A Contract Clinical Trial Manager is a professional who oversees the planning, execution, and management of clinical trials for pharmaceutical, biotech, or medical device companies on a contractual basis. Unlike full-time employees, contract clinical trial managers are typically hired for specific projects or time periods to ensure compliance with regulatory requirements, manage study timelines, and coordinate with cross-functional teams. Their responsibilities include supervising site selection, budget management, and ensuring data quality and patient safety throughout the trial. They play a crucial role in bringing new treatments to market by ensuring trials are conducted efficiently and ethically.

What are the key skills and qualifications needed to thrive as a contract clinical trial manager?

To thrive as a Contract Clinical Trial Manager, you need expertise in clinical research processes, project management, regulatory compliance, and a degree in life sciences or related field. Familiarity with electronic data capture (EDC) systems, clinical trial management systems (CTMS), and certifications such as ACRP or SOCRA are commonly required. Excellent organizational skills, attention to detail, and strong communication enable effective coordination with sponsors, sites, and cross-functional teams. These skills ensure clinical trials meet regulatory standards, timelines, and quality benchmarks critical for successful drug development.

What are some common challenges faced by contract clinical trial managers, and how can they be effectively addressed?

Contract Clinical Trial Managers often navigate challenges such as coordinating multiple stakeholders, adhering to tight timelines, and managing protocol deviations across diverse research sites. To address these, strong communication skills and proactive project management are essential. Developing clear processes for documentation, regular team check-ins, and maintaining flexibility help ensure that trials remain compliant and on schedule. Additionally, leveraging technology for real-time data tracking can streamline collaboration and issue resolution.

What is the difference between Contract Clinical Trial Manager vs Clinical Research Associate?

AspectContract Clinical Trial ManagerClinical Research Associate
CredentialsTypically requires a Bachelor's degree in life sciences, clinical research certification preferredUsually holds a Bachelor's degree in life sciences or related field, with some certifications
Work EnvironmentManages multiple trials, oversees teams, often works remotely or on-site at trial locationsMonitors clinical sites, ensures protocol compliance, works primarily on-site at trial locations
Employer & Industry UsageHired by pharmaceutical companies, CROs, or biotech firms for trial managementEmployed by sponsors or CROs to monitor and support clinical sites

The Contract Clinical Trial Manager focuses on overseeing entire clinical trials, managing teams, and ensuring trial milestones are met. In contrast, the Clinical Research Associate primarily monitors clinical sites to ensure compliance and data integrity. Both roles require similar educational backgrounds but differ in scope and responsibilities within the clinical research process.

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Contract Clinical Trial Manager jobs near you
Infographic showing various Contract Clinical Trial Manager job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 50% In-person, and 50% Remote job distribution, with an average salary of $130,034 per year, or $62.5 per hour.

Clinical Trial Manager/ Sr. Clinical Trial Manager

City Therapeutics

Cambridge, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 23 days ago

Job description

Clinical Trial Manager/ Sr. Clinical Trial Manager
At City Tx, we're building the next generation of siRNA medicines-and a team bold enough to redefine what RNA therapeutics can do. We are pushing the science further and translating breakthrough ideas into meaningful medicines for patients.
We're looking for curiosity, and a willingness to roll up your sleeves and contribute wherever you can make an impact. We are looking for people who embrace ambitious challenges, move with purpose, collaborate generously, and are excited to help build both breakthrough medicines and an exceptional company. If you're energized by ambitious science, meaningful problems, and the opportunity to build something from the ground up, we'd love to hear from you.
We are seeking a motivated Clinical Trial Manager / Senior Clinical Trial Manager (CTM/Sr. CTM) to lead the cross-functional Clinical Study Team, plan and manage the operational aspects of assigned clinical trials ensuring their successful delivery.. In this role, you will serve as the primary point of contact for study leadership, providing strategic direction and operational oversight from endorsement and start-up through execution, close-out, and reporting.
You will partner closely with internal stakeholders, CROs, Investigators/clinical sites and external vendors to deliver Phase 1 dose-escalation through later-phase global clinical trials on time and within budget,, ensuring quality and compliance with ICH-GCP and regulatory requirements.
This is a full-time onsite opportunity
Responsibilities:
  • Plan and manage the operational aspects of clinical trials throughout the trial's lifecycle (study start-up, execution and maintenance, close-out, and reporting), ensuring that milestones, objectives, and deliverables are aligned with the Clinical Development Plan and program and company goals.
  • Lead cross-functional clinical study teams and serve as the primary point of contact for trial-related activities and updates to internal leadership.
  • Contribute to clinical trial strategy, including supporting protocol development, country and site selection, vendor identification, risk management, and development of study timelines and budgets.
  • Oversee the development and maintenance of key study documents such as informed consent forms, study management plans, submission packages, GDPR compliance materials, and annual reports.
  • Drive vendor and CRO performance through oversight plans, performance tracking, and issue resolution.
  • Foster strong partnerships with investigators, site staff, external partners and internal stakeholders to support efficient study execution and achievement of enrollment and delivery targets.
  • Identify and proactively manage study risks with mitigation strategies and appropriate escalation. Ensure compliance with GCP, SOPs, and regulatory requirements across all operational activities. Champion inspection readiness and support audits and regulatory inspections, including CAPA development.
  • Lead the study-level budgeting and site contracting process, in partnership with legal and finance teams. Monitor vendor financial performance and review invoices, change orders, and scopes of work to ensure financial accountability.
  • Oversee CRO management of the Trial Master File (TMF), ensuring completeness and quality. Ensure timely and accurate registration and updates in clinical trial registries (e.g., ClinicalTrials.gov).
  • Identify and implement opportunities to improve clinical operations processes and drive efficiency. Contribute to departmental goals and strategic initiatives.

Qualifications:
  • Bachelor's degree in a life sciences or healthcare-related discipline (advanced degree a plus).
  • Minimum of 6 years of experience in clinical trial management within biotech or pharmaceutical industry.
  • Strong project management skills with a proactive, solutions-oriented mindset.
  • Excellent interpersonal, communication, and organizational skills.
  • Proven ability to manage vendors and CROs, driving accountability and high-quality deliverables.
  • Deep knowledge of clinical trial regulations and guidelines (ICH-GCP, FDA, EMA, etc.).
  • Ability to work independently and collaboratively in a dynamic, cross-functional team environment.
  • Willingness to travel up to 15%, including international travel.

City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment Agency inquiries or submissions will not be accepted at this time.
Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match. Per Year Salary Range: $164,000 to $185,000
City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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