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Clinical Monitoring Jobs (NOW HIRING)

Prometrika LLC

Clinical Trial Manager

Cambridge, MA · On-site

$140K - $168K/yr

Manage the operational aspects of clinical trials (e.g., study management, site monitoring and management, trial master file (TMF) oversight,) * Coordinate and support regulatory submissions and ...

Immatics NV

Senior Clinical Research Associate

$120K - $135K/yr

The Senior CRA will be responsible for overseeing clinical trial site management and monitoring activities to ensure compliance with ICH-GCP, regulatory requirements, and company SOPs. In this role ...

Vanguard Clinical

Clinical Operations Associate (Pool)

CA · Remote

$70K - $80K/yr

We are experts in clinical trial operations with a focus on Clinical Trial Management, CRO/Vendor Oversight, Trial Master File Management, Clinical Monitoring, Quality Assurance, Data Management and ...

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Clinical Monitoring information

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$12

$41

$69

How much do clinical monitoring jobs pay per hour?

As of Jul 22, 2026, the average hourly pay for clinical monitoring in the United States is $41.13, according to ZipRecruiter salary data. Most workers in this role earn between $28.85 and $52.64 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Clinical Monitoring, and why are they important?

To thrive in Clinical Monitoring, you need a solid background in life sciences or nursing, strong knowledge of clinical trial protocols, and often a relevant degree such as a BS in a scientific field. Familiarity with electronic data capture (EDC) systems, Good Clinical Practice (GCP) guidelines, and certifications like ACRP or SOCRA are highly valued. Exceptional attention to detail, strong organizational skills, and effective communication are crucial soft skills for managing trial sites and ensuring compliance. These competencies are vital for ensuring data integrity, regulatory adherence, and the smooth progress of clinical trials.

What is the difference between Clinical Monitoring vs Clinical Data Management?

AspectClinical MonitoringClinical Data Management
Primary RoleOversees site activities, ensures protocol adherence, monitors patient safetyCollects, validates, and manages clinical trial data
Required CredentialsTypically a degree in life sciences, nursing, or related field; often requires monitoring certificationsDegree in life sciences, biostatistics, or related; data management certifications beneficial
Work EnvironmentOn-site at clinical trial sites or remotely, interacting with site staffPrimarily office-based, working with electronic data capture systems
Industry UsageCommonly used in clinical trial phases, especially during site visitsUsed throughout the trial for data collection, cleaning, and analysis

Clinical Monitoring focuses on overseeing clinical trial sites and ensuring compliance, while Clinical Data Management handles the collection and validation of trial data. Both roles are essential in clinical research, often working closely but with distinct responsibilities.

What is clinical monitoring?

Clinical monitoring is the process of overseeing clinical trials to ensure they are conducted, recorded, and reported in accordance with the protocol, standard operating procedures, Good Clinical Practice (GCP), and regulatory requirements. Clinical monitors, often called Clinical Research Associates (CRAs), are responsible for checking the progress of a clinical trial at research sites, verifying data accuracy, ensuring participant safety, and ensuring compliance with regulations. Their work is essential in maintaining the integrity of clinical data and the safety of trial participants.

What are some common challenges faced by professionals in Clinical Monitoring, and how can they be addressed?

Clinical Monitoring professionals often encounter challenges such as managing multiple study sites, ensuring protocol compliance, and maintaining clear communication with site staff. Navigating regulatory requirements and handling unexpected issues, like protocol deviations or data discrepancies, can also be demanding. To address these, strong organizational skills, proactive communication, and thorough documentation are essential. Building collaborative relationships with site personnel and staying updated on regulatory guidelines can help ensure smoother study progress and data integrity.
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Clinical Monitoring jobs near you
Infographic showing various Clinical Monitoring job openings in the United States as of July 2026, with employment types broken down into 2% As Needed, 73% Full Time, 17% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $85,542 per year, or $41.1 per hour.
Senior Clinical Research Associate

Senior Clinical Research Associate

eGenesis

Cambridge, MA • On-site

Full-time

Re-posted 11 days ago

Job description

About eGenesis
eGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company's proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses. EGEN-2784, a genetically engineered porcine kidney, is the Company's lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.
eGenesis is seeking a Senior Clinical Research Associate with 4+ years of experience monitoring complex clinical trials in pharmaceutical, biotechnology, and CRO environments. Demonstrated experience in independently managing investigative sites and conducting site qualification, initiation, routine monitoring (on-site and remote), and closeout visits, while ensuring compliance with ICH-GCP, regulatory requirements, and study protocols. Proven ability to oversee site performance, maintain data integrity through source data verification and CRF review, and ensure timely documentation in eTMF, CTMS, and EDC systems. Skilled in supporting site start-up, training investigators and site staff, and providing operational guidance to academic medical centers and sites with limited IND experience. The ideal person for this role is experienced in identifying operational risks, implementing mitigation strategies, and managing high volume clinical data to maintain patient safety and data quality and study compliance. You will work under the guidance of the Lead CRA or Clinical Operations leadership to execute monitoring strategies and ensure consistent oversight of assigned sites. We are looking for a collaborative team member who works closely with investigative sites and cross-functional teams to support enrollment, resolve operational challenges and maintain inspection readiness.
PRIMARY RESPONSIBILITIES
  • Conduct site qualification, initiation, routine monitoring (on-site and remote), and closeout visits in accordance with the Clinical Monitoring Plan and study timelines
  • Independently manage assigned investigative sites, including academic medical centers with limited IND experience, providing operational guidance to ensure protocol compliance, data quality, and effective management of high-volume clinical data
  • Oversee clinical trial conduct at assigned sites to ensure protocol compliance, patient safety, data integrity, and accurate documentation
  • Perform source data verification and review case report forms (CRFs) to ensure completeness, accuracy, and compliance with study requirements
  • Prepare/finalize monitoring visit reports and follow-up communications within required timelines
  • Train and support Principal Investigators and site staff on protocol procedures, regulatory requirements and GCP compliance
  • Support site start-up and activation activities, including collection, review, and tracking of regulatory and essential documents
  • Contribute to investigator selection and site feasibility assessments during study planning
  • Partner with investigative sites to support patient recruitment and retention efforts and address enrollment barriers
  • Monitor site performance and key study metrics (e.g., recruitment, data entry timelines, query resolution) to assess site performance and identify potential operational or compliance risks
  • Evaluate site operational challenges, implement practical solutions to support site performance and study compliance, and escalate significant issues project leadership as appropriate
  • Provide operational guidance and education to investigative site personnel, particularly at academic centers with limited IND experience, to support protocol implementation, regulatory compliance, and management of complex study procedures and data requirements
  • Support risk-based monitoring activities by evaluating site performance indicators and identifying emerging operational or compliance risks
  • Maintain accurate and timely documentation of monitoring activities and study records within the eTMF, CTMS, and other required tracking systems
  • Collaborate with Clinical Operations and cross-functional teams to support effective study execution
  • Support audit and regulatory inspection readiness, including participation in preparation activities and documentation review

QUALIFICATIONS
  • Bachelor's degree in life sciences, nursing, or related field required; advanced degree preferred
  • 4+ years of clinical monitoring experience in the pharmaceutical, biotechnology, or CRO industry
  • Experience managing academic medical center sites and supporting investigators or site teams with limited experience in industry-sponsored IND trials
  • Experience managing sites with high data volume and ensuring timely source documentation, CRF completion, and query resolution
  • Direct monitoring experience conducting all monitoring visit types including site qualification, site initiation, interim monitoring, and close-out visits
  • High preference for monitoring complex clinical trials involving critically ill or high-acuity patient populations (e.g., gene/cell therapy or transplant)
  • Strong knowledge of ICH-GCP guidelines, regulatory requirements, and clinical trial operations
  • Experience independently managing multiple investigative sites across the monitoring lifecycle and working in a cross-functional team environment
  • Strong organizational, communication, and problem-solving skills
  • Familiarity with eTMF, CTMS, and electronic data capture (EDC) systems
  • Team oriented and flexible; ability to respond quickly to shifting demands and opportunities
  • High attention to detail and commitment to quality
  • Ability to travel as required to conduct on-site monitoring visits

Base pay range for this job is $105,600-$158,400.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

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