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At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. We are passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring innovative ideas to life. Respiratory & Immunology, part of AstraZeneca BioPharmaceuticals is a key disease area and growth driver to the Company.
Our ambition is to improve and save lives for the millions of people who are living with the complexities of Cardiovascular, Renal & Metabolic (CVRM) diseases. AstraZeneca is uniquely positioned to improve the outcomes of patients living with CVRM diseases today and tomorrow with our strong and expanding portfolio and one of the broadest, deepest, most innovative pipelines in the industry. By 2032, we intend to be leading the world in CVRM therapies, launching up to 15 new life-changing medicines.
To support this ambition, we are seeking a Global Commercial Head, Weight Management, a high-impact, global leadership role responsible for shaping and delivering commercial strategy across our Weight Management portfolio. This individual will play a critical role in defining the future of the category, enabling successful global launches, and driving long-term brand and portfolio value.
What You'll Do

• Shape clear, actionable, winning commercial strategies across multiple assets and indications in the Weight Management portfolio.
• Lead development of integrated global commercial strategies, including pre-launch, launch, and lifecycle planning
• Develop and execute strategic and operational plans covering positioning, segmentation, pricing, value proposition, and target market prioritization
• Represent the global commercial perspective to inform clinical development, regulatory strategy, and lifecycle decisions
• Lead cross-functional global teams to deliver differentiated target product profiles and maximize asset value
• Drive forecasting, business case development, and performance tracking to inform decision-making and portfolio prioritization
• Partner closely with regional and market organizations to ensure alignment from global strategy through to local execution
• Collaborate with Medical, Market Access, Regulatory, R&D, and other key functions to ensure compliant and impactful delivery of commercial plans
• Build strong relationships with external stakeholders including key opinion leaders, advocacy groups, and industry partners
• Lead and develop a high-performing global team, fostering innovation, accountability, and talent development aligned to AstraZeneca values

Minimum Qualifications

• Bachelor's degree in business, life sciences, or related field
• 10+ years experience in the pharmaceutical, biotechnology, or healthcare industry
• Demonstrated success in global or US commercial leadership roles, including launch experience
• Proven track record developing and executing brand or therapeutic area strategies grounded in customer and market insights
• Experience leveraging clinical data to inform strategy and lifecycle planning
• Strong leadership capabilities with experience managing cross-functional and global teams
• Ability to influence senior stakeholders and drive alignment across complex organizations

Preferred Qualifications

• Advanced degree (e.g., MBA, PhD, or MD)
• Experience in CVRM and/or Weight Management
• Strong understanding of global healthcare systems, pricing, and market access dynamics
• Experience with forecasting, financial planning, and business case development
• Demonstrated ability to identify innovative, high-impact strategies and deliver results
• High learning agility, strategic mindset, and strong communication skills

Why AstraZeneca
This position is based at our Boston, MA campus. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and bold world.
AstraZeneca offers an environment where you can thrive by working with new drugs, digital approaches, and ever-changing environments. Our pioneering value-based agreements and Innovative Value Strategy solutions lead the way in the industry. We are driven by our determination to ensure the value of our medicines is realized. Our dynamic environment encourages creativity in designing strategies and innovative access solutions. We thrive on co-creation and draw on diverse perspectives to overcome challenges. Join us to be part of a team that is passionate about making a meaningful impact on patient outcomes.
Ready to make a difference? Apply now to join our team!
The annual base pay for this position ranges from $267,913 - 401,870 USD. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Date Posted
06-Jul-2026
Closing Date
30-Jul-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.