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Weekend Prn Rn Jobs in Lancaster, SC (NOW HIRING)

Shiftkey, LLC

RN

Lancaster, SC · On-site

$49/hr

If you're tired of having no control over your schedule or just want to earn more money, PRN shifts could be what you're looking for! ShiftKey enables independent Registered Nurses like you to bid on ...

MUSC

Registered Nurse - Neuro/PCU - PRN

Lancaster, SC · On-site

$1.7K - $2.3K/wk

PRN Status Clause: This is a PRN as-needed position, you must be available to work at least 12 ... Current South Carolina or compact state Registered Nurse license is required. * Current Basic Life ...

MUSC

Registered Nurse

Lancaster, SC · On-site

The RN II provides nursing care using the nursing process, directing team members and collaborating ... Entity MUSC Community Physicians (MCP) Worker Type Employee Worker Sub-Type​ PRN Cost Center ...

Posted today

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Weekend Prn Rn information

See Lancaster, SC salary details

$16

$31

$45

How much do weekend prn rn jobs pay per hour?

As of Sep 2, 2026, the average hourly pay for weekend prn rn in Lancaster, SC is $31.11, according to ZipRecruiter salary data. Most workers in this role earn between $24.81 and $35.87 per hour, depending on experience, location, and employer.

What is a Weekend PRN RN?

A Weekend PRN RN (As Needed Registered Nurse) is a nursing position where the nurse works primarily on weekends and on an as-needed basis. These roles are typically found in hospitals, nursing homes, and healthcare facilities that require additional weekend staffing. PRN nurses do not usually have a set schedule and may be called to fill in for staff shortages. This role offers flexibility but may not guarantee a certain number of hours. Weekend PRN RNs must still meet licensing and certification requirements like full-time nurses.

What are the typical shift expectations and workload for a Weekend PRN RN?

Weekend PRN RN positions usually require nurses to work flexible hours on Saturdays and Sundays, with potential opportunities for additional shifts based on staffing needs. The workload can vary each weekend, depending on patient census and acuity, so adaptability is important. These roles often involve collaborating with a leaner weekend team, requiring strong teamwork and autonomy. While you may not have a set schedule every week, PRN positions can offer valuable hands-on experience and are ideal for nurses seeking flexibility or supplemental income.

What are the key skills and qualifications needed to thrive in the Weekend PRN RN position, and why are they important?

To thrive as a Weekend PRN RN, you need a current RN license, strong clinical assessment abilities, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems, medication administration protocols, and facility-specific safety procedures is important. Flexibility, excellent communication, and the ability to work independently are valuable soft skills for managing varied shifts and patient needs. These competencies ensure that you can provide high-quality care and respond effectively to weekend staffing and patient demands.

Do PRN registered nurses have to work weekends?

PRN registered nurses are scheduled on an as-needed basis and are not typically required to work weekends unless assigned to weekend shifts. Their work schedule depends on the facility's staffing needs and the nurse's availability, often offering flexibility. However, some PRN positions may include weekend shifts if the facility requires coverage during those times.

What job categories do people searching Weekend Prn Rn jobs in Lancaster, SC look for?

The top searched job categories for Weekend Prn Rn jobs in Lancaster, SC are:

What cities near Lancaster, SC are hiring for Weekend Prn Rn jobs?

Cities near Lancaster, SC with the most Weekend Prn Rn job openings:

Weekend Prn Rn jobs near you
Infographic showing various Weekend Prn Rn job openings in Lancaster, SC as of August 2026, with employment types broken down into 1% As Needed, 67% Full Time, 29% Part Time, 2% Contract, and 1% Nights. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution, with an average salary of $64,702 per year, or $31.1 per hour.

Registered Nurse - PRN (As Needed) - Telemetry

MUSC Health & Medical University of SC

Lancaster, SC • On-site

Part-time

Re-posted 5 days ago

MUSC Health rating

7.0

Company rating: 7.0 out of 10

Based on 202 frontline employees who took The Breakroom Quiz

421st of 898 rated healthcare providers

Job description

Job Description Summary
Growth and Success go hand and hand. Let us help you with that. Come join our MUSC Health Family
Entity
Medical University Hospital Authority (MUHA)
Worker Type
Employee
Worker Sub-Type
PRN
Cost Center
CC001507 LAN - MedSurg 5th Floor (LMC)
Pay Rate Type
Hourly
Pay Grade
Health-26
Scheduled Weekly Hours
12
Work Shift
Rotating (United States of America)
Job Description
Registered nurses (RNs) are responsible for providing safe, competent patient care, educating patients and their families about health conditions, and providing advice and emotional support to patients and their families.
PRN Status Clause:
This is a PRN as-needed position, you must be available to work at least 12 hours bi-weekly, as needed according to departmental demands. You may be required to work additional hours if requested by your supervisor to accomplish work objectives. Work hours may vary (increase or decrease) depending on the needs of the unit.
Additional Job Description
Education:
  • Graduate from an accredited school of nursing

License and Certifications:
  • Current South Carolina or compact state Registered Nurse license is required.
  • Current Basic Life Support (BLS) with the American Heart Association (AHA) is required

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees

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About MUSC Health

Sourced by ZipRecruiter

MUSC is located in Charleston, SC, frequently named one of the best places in America to live. If charming, historic, vibrant, cultural, and coastal are adjectives that you find appealing, it's all here. In Charleston, you might find yourself dining at a world class restaurant tonight and relaxing on a boat as you explore our many waterways tomorrow. You might stroll along cobblestone streets, amidst centuries old homes by day and attend a jazz concert by night. Charleston is a place where you can live your life to its fullest.

Industry

Hospitality services

Company size

10,000+ Employees

Headquarters location

Charleston, SC, US

Year founded

1824

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