Upstream Process Development Scientist Experience in development of mammalian cell culture processes for the production of recombinant proteins is a plus. Knowledge of protein chemistry and ...
Upstream Process Development Scientist Experience in development of mammalian cell culture processes for the production of recombinant proteins is a plus. Knowledge of protein chemistry and ...
The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processes for in vivo therapeutic programs. This role will contribute ...
The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processes for in vivo therapeutic programs. This role will contribute ...
Design, analyze and interpret lab experiments, purification data, in-process trends, productivity and quality attributes to support upstream process development. Lead efforts to evaluate different ...
Design, analyze and interpret lab experiments, purification data, in-process trends, productivity and quality attributes to support upstream process development. Lead efforts to evaluate different ...
Design, analyze and interpret lab experiments, purification data, in-process trends, productivity and quality attributes to support upstream process development. * Lead efforts to evaluate different ...
Design, analyze and interpret lab experiments, purification data, in-process trends, productivity and quality attributes to support upstream process development. * Lead efforts to evaluate different ...
The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processesfor invivo therapeutic programs. This role will contribute ...
The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processesfor invivo therapeutic programs. This role will contribute ...
The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processesfor invivo therapeutic programs. This role will contribute ...
The Scientist, Upstream Process Development will support development, optimization, and characterization of scalable cell culture processesfor invivo therapeutic programs. This role will contribute ...
Associate Scientist/Scientist, Upstream Process Development Salary range: * Associate Scientist: 100,000-120,000 per year * Scientist: 120,000-150,000 per year Are you eager to drive innovation at ...
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Associate Scientist/Scientist, Upstream Process Development Salary range: * Associate Scientist: 100,000-120,000 per year * Scientist: 120,000-150,000 per year Are you eager to drive innovation at ...
New
Position Summary The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of ...
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Position Summary The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of ...
Position Summary The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of ...
Position Summary The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of ...
Vice President, Upstream Process Development MIDWEST OR (Preferably) OMAHA, NE ABOUT US: We use American corn and existing bioethanol infrastructure to produce critical chemicals right here at home ...
Vice President, Upstream Process Development MIDWEST OR (Preferably) OMAHA, NE ABOUT US: We use American corn and existing bioethanol infrastructure to produce critical chemicals right here at home ...
Position Summary The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of ...
Position Summary The primary role of the Associate Scientist, Upstream Process Development is to execute laboratory experiments in the development, optimization, characterization, and scale-up of ...
Vice President, Upstream Process Development MIDWEST OR (Preferably) OMAHA, NE ABOUT US: We use American corn and existing bioethanol infrastructure to produce critical chemicals right here at ...
Quick apply
Vice President, Upstream Process Development MIDWEST OR (Preferably) OMAHA, NE ABOUT US: We use American corn and existing bioethanol infrastructure to produce critical chemicals right here at ...
Client is seeking an experienced and driven scientist/engineer to lead late-stage upstream cell culture process development activities for clinical and commercial-stage large molecule programs. This ...
Client is seeking an experienced and driven scientist/engineer to lead late-stage upstream cell culture process development activities for clinical and commercial-stage large molecule programs. This ...
Vice President, Upstream Process Development MIDWEST OR (Preferably) OMAHA, NE ABOUT US: We use American corn and existing bioethanol infrastructure to produce critical chemicals right here at home ...
Vice President, Upstream Process Development MIDWEST OR (Preferably) OMAHA, NE ABOUT US: We use American corn and existing bioethanol infrastructure to produce critical chemicals right here at home ...
Participates in and/or leads upstream process development of first-in-human and commercial processes by efficiently developing high yield, robust, and scalable cell culture processes. Responsible for ...
Participates in and/or leads upstream process development of first-in-human and commercial processes by efficiently developing high yield, robust, and scalable cell culture processes. Responsible for ...
Associate Principal Scientist, Upstream Process Development
Rahway, NJ · On-site
$142 - $224/hr
Participates in and/or leads upstream process development of first-in-human and commercial processes by efficiently developing high yield, robust, and scalable cell culture processes. * Responsible ...
Associate Principal Scientist, Upstream Process Development
Rahway, NJ · On-site
$142 - $224/hr
Participates in and/or leads upstream process development of first-in-human and commercial processes by efficiently developing high yield, robust, and scalable cell culture processes. * Responsible ...
Participates in and/or leads upstream process development of first-in-human and commercial processes by efficiently developing high yield, robust, and scalable cell culture processes. * Responsible ...
Participates in and/or leads upstream process development of first-in-human and commercial processes by efficiently developing high yield, robust, and scalable cell culture processes. * Responsible ...
Principal Scientist, Upstream Process Development
Rahway, NJ · On-site
$173 - $273/hr
Leading biologic upstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable cell culture processes. * Providing technical ...
Principal Scientist, Upstream Process Development
Rahway, NJ · On-site
$173 - $273/hr
Leading biologic upstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable cell culture processes. * Providing technical ...
Leading biologic upstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable cell culture processes. * Providing technical ...
Leading biologic upstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable cell culture processes. * Providing technical ...
Leading biologic upstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable cell culture processes. * Providing technical ...
Leading biologic upstream process development for first-in-human and commercial processes by efficiently developing high yield, robust and scalable cell culture processes. * Providing technical ...
Upstream Process Development information
See salary details
$18.99 - $20.67
4% of jobs
$20.67 - $22.36
5% of jobs
$23.45 is the 25th percentile. Wages below this are outliers.
$22.36 - $24.04
24% of jobs
The median wage is $25.07 / hr.
$24.04 - $25.72
27% of jobs
$27.40 is the 75th percentile. Wages above this are outliers.
$25.72 - $27.40
15% of jobs
$27.40 - $29.09
13% of jobs
$29.09 - $30.77
5% of jobs
$30.77 - $32.45
4% of jobs
$32.45 - $34.13
2% of jobs
$34.13 - $35.82
1% of jobs
$35.82 - $37.50
0% of jobs
$18
$26
$37
How much do upstream process development jobs pay per hour?
As of Aug 25, 2026, the average hourly pay for upstream process development in the United States is $26.51, according to ZipRecruiter salary data. Most workers in this role earn between $23.56 and $27.88 per hour, depending on experience, location, and employer.
What are the key skills and qualifications needed to thrive in upstream process development?
Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.
What are some common challenges faced in upstream process development and how do teams typically address them?
One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.
What is the difference between Upstream Process Development vs Downstream Process Development?
| Aspect | Upstream Process Development | Downstream Process Development |
|---|---|---|
| Focus | Development of cell culture, fermentation, and bioreactor processes | Purification, filtration, and formulation of bioproducts |
| Skills & Credentials | Bioprocess engineering, molecular biology, biochemistry | Bioprocessing, chromatography, analytical chemistry |
| Work Environment | Laboratories, bioreactors, pilot plants | Purification facilities, labs, quality control |
| Industry Usage | Biotech, pharmaceutical manufacturing | Biotech, pharmaceutical manufacturing |
Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.
What are common upstream process development jobs?
Common upstream process development jobs include roles such as upstream process scientist, process engineer, and bioprocess development specialist. These positions focus on optimizing cell culture, fermentation, and bioreactor processes to improve product yield and quality, often requiring knowledge of bioreactor operation, cell biology, and process scale-up. Skills in laboratory techniques, process modeling, and regulatory compliance are also important in these roles.
What is an upstream process development job?
An upstream process development job involves designing, optimizing, and scaling the early stages of biopharmaceutical production, such as cell culture and fermentation processes. Professionals in this role typically work with bioreactors, laboratory equipment, and process analytical tools to improve yield and quality of biological products. Strong knowledge of microbiology, biochemistry, and process engineering is essential, along with adherence to regulatory standards.
More about Upstream Process Development jobs
What cities are hiring for Upstream Process Development jobs?
Cities with the most Upstream Process Development job openings:
What states have the most Upstream Process Development jobs?
States with the most job openings for Upstream Process Development jobs include:
What job categories do people searching Upstream Process Development jobs look for?
The top searched job categories for Upstream Process Development jobs are:
- Upstream Process Development Scientist
- Vice President Scientist Process Chemistry
- Senior Scientist Process Chemistry
- Senior Scientist Downstream Process Development
- Associate Scientist Cell Culture
- Associate Process Development Scientist
- Scientist Cell Culture Process Development
- Phd Drug Development Scientist
- Scientist Cell Culture Phd
- Stealth Mode Biotech
Upstream Process Development
South Plainfield, NJ
Integrated Resources INC •Â
Recruiting and Staffing Services • 51 - 200 employees51 - 200 employees
Full-time
Re-posted 6 days ago
Job description
Company Description
A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.
Job Description
Upstream Process Development Scientist
Experience in development of mammalian cell culture processes for the production of recombinant proteins is a plus. Knowledge of protein chemistry and purification techniques and purification process development experience is preferred. Basic knowledge of cGMP policies and procedures. Basic knowledge of regulatory requirements of the pharmaceutical / biotechnology industry.
Key Responsibilities:
Design and execute experiments for production of proteins using microbial fermentation processes.     Design, analyze and interpret lab experiments, purification data, in-process trends, productivity and quality attributes to support upstream process development.
Lead efforts to evaluate different fermentation media, feeds, and feeding strategies to improve product yield and quality including proper folding of protein
Scale up process developed at research stage to manufacture adequate amounts of protein to support clinical trials
Author technical documentation including process validation protocols and reports.
Evaluate process robustness, investigate causes of process variances, and take steps to maximize process reproducibility.
Qualifications
Basic qualifications: Ph.D., MS or BS in Chemical/Biochemical Engineering or related Biological Sciences is required. For a candidate with a Ph.D. >3 yrs. of industrial experience; candidate with an MS >5 yrs. industrial experience and for a candidate with a BS, >7 years of industrial experience in developing upstream microbial fermentation processes for the production of bio-pharmaceuticals is required. Specific experience in development of microbial expression processes for soluble protein production is preferred.
Additional Information
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About Integrated Resources
Sourced by ZipRecruiter
Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.
Industry
Recruiting and staffing services
Company size
51 - 200 Employees
Headquarters location
Edison, NJ, US
Year founded
1996