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Upstream Process Development Jobs in Bothell, WA

Experience in both early- and late-stage bioreactor operations, mammalian stable cell line development, and upstream process development is preferred. * Demonstrated expertise in advanced ...

... upstream development (product design, material selection) and downstream integration (FATP). You ... Manufacturing Process Development: Develop optimized, scalable manufacturing processes for robotics ...

... upstream development (product design, material selection) and downstream integration (FATP). You ... Responsibilities Manufacturing Process Development: Develop optimized, scalable manufacturing ...

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Upstream Process Development information

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How much do upstream process development jobs pay per hour?

As of Sep 15, 2026, the average hourly pay for upstream process development in Bothell, WA is $29.64, according to ZipRecruiter salary data. Most workers in this role earn between $26.35 and $31.15 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in upstream process development?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What are common upstream process development jobs?

Common upstream process development jobs include roles such as upstream process scientist, process engineer, and bioprocess development specialist. These positions focus on optimizing cell culture, fermentation, and bioreactor processes to improve product yield and quality, often requiring knowledge of bioreactor operation, cell biology, and process scale-up. Skills in laboratory techniques, process modeling, and regulatory compliance are also important in these roles.

What is an upstream process development job?

An upstream process development job involves designing, optimizing, and scaling the early stages of biopharmaceutical production, such as cell culture and fermentation processes. Professionals in this role typically work with bioreactors, laboratory equipment, and process analytical tools to improve yield and quality of biological products. Strong knowledge of microbiology, biochemistry, and process engineering is essential, along with adherence to regulatory standards.

What are popular job titles related to Upstream Process Development jobs in Bothell, WA?

For Upstream Process Development jobs in Bothell, WA, the most frequently searched job titles are:

What job categories do people searching Upstream Process Development jobs in Bothell, WA look for?

The top searched job categories for Upstream Process Development jobs in Bothell, WA are:

What cities near Bothell, WA are hiring for Upstream Process Development jobs?

Cities near Bothell, WA with the most Upstream Process Development job openings:

Infographic showing various Upstream Process Development job openings in Bothell, WA as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 80% Full Time, 15% Part Time, 1% Temporary, and 2% Contract. Highlights an 84% Physical, 4% Hybrid, and 12% Remote job distribution, with an average salary of $61,652 per year, or $29.6 per hour.

Senior Scientist I, Purification Process Development

Redmond, WA • On-site

$126K - $137K/yr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 27 days ago


Key responsibilities

  • Support purification process development at the bench and pilot scale, focusing on low-cost biotherapeutics manufacturing.

  • Lead a team of scientists in purification process development, characterization, validation, and technology transfer to cGMP manufacturing.

  • Design, execute, and analyze experiments, and communicate scientific data to internal teams, clients, and partners.


Job description

Job Title

Senior Scientist I, Purification Process Development

Location

Redmond, WA

Reports To

Director, Process Sciences

About Us

At Just‑Evotec, we believe curiosity is the spark that drives innovation and success. We thrive on challenging the status quo, learning from one another, and pushing the boundaries of what’s possible.

Role Overview

The Purification Process Development group seeks an enthusiastic and hardworking team member who is passionate about expanding worldwide access to biotherapeutics through continuous bioprocessing technology. This person will support purification process development at the bench and pilot scale, focusing on low‑cost biotherapeutics manufacturing.

Responsibilities
  • Lead a diverse group of scientists in purification process development, characterization, and validation, including technology transfer to cGMP manufacturing for hybrid and continuous processes.
  • Serve as an internal technical resource for cGMP manufacturing and Process Design, and act as a subject‑matter expert for external clients and partners on purification processes, authoring CMC regulatory sections.
  • Lead platform or complex client early‑stage (FIH) and late‑stage Process Characterization projects, as well as technology development projects.
  • Serve as a Project Team Lead to execute client projects that involve multiple functional areas for platform and early‑stage (FIH) projects.
  • Communicate scientific information, experimental plans, and data to internal project teams, senior management, external clients, vendors, and technology development collaborators.
  • Independently design, execute, and analyze statistically designed experiments (DOE).
  • Author SOPs, reports, and slides that summarize, organize, and interpret experiment results with review by appropriate team members.
  • Train, mentor, and supervise staff and interns.
  • Drive technology development for process intensification and continuous manufacturing to reduce manufacturing costs and footprint through improvements in culture productivity, control of product quality, and data management.
  • Support the management of staff, capital resources, and planning within the department.
  • Perform other assigned tasks as needed.
Qualifications
  • BS/MS in Engineering, Biochemistry, Biology, or related field with 8+ years of experience, or Ph.D. in the same areas with 4+ years of experience.
  • Expertise in purification technology and process development, transfer to cGMP manufacturing plants, and authoring CMC sections of regulatory filings.
  • Experience with commercial process development, process characterization, and validation.
  • Expertise in design of experiments (DOE) and statistical analysis.
  • Experience in training, mentoring, and supervising team members and leading development teams for external client projects and collaborations.
  • Experience with high‑throughput process development systems is a plus.
  • Analytical skills using tools such as JMP, R, or Python.
  • General understanding of cell biology, fluid dynamics, and protein chemistry, with broader knowledge in upstream and analytical sciences.
  • Experience working in a cGMP or clean‑room setting (knowledge of GMP is helpful for process/tech transfer activities).
Benefits & Opportunities
  • Base salary range: $126,000 to $137,000, subject to skills, experience, and market value.
  • Discretionary annual bonus.
  • Comprehensive health benefits including medical, dental, vision.
  • Short‑term and long‑term disability; company‑paid basic life insurance.
  • 401(k) company match.
  • Flexible work arrangements and generous paid time off, holidays, and paid family leave.
  • Wellness and transportation benefits.
Growth Opportunities

We provide continuous learning and development through professional courses, mentorship, and new projects, and we foster an inclusive environment where curiosity is encouraged.

Equal Opportunity Employer

Evotec (US) Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status.

Company Overview

Just‑Evotec Biologics is a first‑to‑industry platform that leverages AI/ML technologies and world‑leading molecular design, cell line development, process intensification, and continuous manufacturing strategies to advance biotherapeutics from discovery through clinical stages to commercial launch. Our team combines deep experience in data, protein, process, and manufacturing sciences, including automation, to accelerate access to biotherapeutics for partners and our proprietary projects.

Contact

Learn more at www.just-evotecbiologics.com.

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