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Upstream Process Development Jobs in Houston, TX

Persona AI

Process Engineer

Houston, TX · On-site

You will lead the development implementation and optimization of a robust manufacturing process of ... Partner with engineering during design reviews to influence DFM/DFA decisions upstream before they ...

Winaxis

SAP Upstream Finance Consultant

Houston, TX · On-site

Job Summary for SAP Upstream Finance Consultant - Specialize in the upstream finance workstream ... developments within PSA. - Provide expertise on SAP Best Practices for business processes and end ...

SIGNOBIO INC

Upstream Associate

Houston, TX · On-site

Our core technology platform is an in-house-developed mammalian cell-based recombinant expression ... processes for high-efficiency production of antigens and antibodies. We are headquartered in ...

Prim

Senior Process Engineer

Houston, TX · On-site

$99K - $128K/yr

... upstream, midstream, and petrochemical markets. Our core focus is Facilities and Pipelines ... Process Flow and P&ID Development * Prepare the Line List * PSV/relief calculations * Flare Study

Upstream Rehabilitation

Physical Therapist

Houston, TX · On-site

$1.5K - $2.0K/wk

Continue developing your leadership and clinical skills through Upstream's professional development ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

Upstream Rehabilitation

Physical Therapist

Pasadena, TX · On-site

$1.5K - $1.9K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

Upstream Rehabilitation

Physical Therapist

Richmond, TX · On-site

$1.3K - $1.7K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

Upstream Rehabilitation

Physical Therapist

Klein, TX · On-site

$1.5K - $1.9K/wk

Continue learning and growing through Upstream's education and development programs Qualifications ... Specific details will be provided during the hiring process. Upstream Rehabilitation is an Equal ...

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Upstream Process Development information

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How much do upstream process development jobs pay per hour?

As of Aug 14, 2026, the average hourly pay for upstream process development in Houston, TX is $25.32, according to ZipRecruiter salary data. Most workers in this role earn between $22.50 and $26.63 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in upstream process development?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.

What are popular job titles related to Upstream Process Development jobs in Houston, TX?

For Upstream Process Development jobs in Houston, TX, the most frequently searched job titles are:

What job categories do people searching Upstream Process Development jobs in Houston, TX look for?

The top searched job categories for Upstream Process Development jobs in Houston, TX are:

What cities near Houston, TX are hiring for Upstream Process Development jobs?

Cities near Houston, TX with the most Upstream Process Development job openings:

Upstream Process Development jobs near you
Infographic showing various Upstream Process Development job openings in Houston, TX as of August 2026, with employment types broken down into 1% As Needed, 86% Full Time, 11% Part Time, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $52,667 per year, or $25.3 per hour.

Process Safety & Technical Risk Manager

Caturus Management Services, LLC

Houston, TX • On-site

Full-time

Re-posted 23 hours ago

Job description

Process Safety & Technical Risk Manager
Department: HSSE
Employment Type: Full Time
Location: US TX Houston - Corporate Office
Description
About Us:
The Caturus platform founded by Kimmeridge - an alternative asset manager focused on the energy sector - supports Kimmeridge's overarching goal of providing low-cost energy on demand with the lowest carbon footprint.
Kimmeridge's vision in creating Caturus is to build the only independent, fully integrated natural gas and LNG export platform in the U.S. through a combination of its upstream operations and via Commonwealth LNG, a 9.5 million tonnes per annum liquefied natural gas export terminal in southwestern Louisiana on the U.S. Gulf Coast. The combined entities are committed to delivering responsibly sourced, low-emission fuel to domestic and international markets.
Caturus is a Houston-based, private exploration and production company seeking to materially grow production through development of deep, high pressure, dry gas windows of the Eagle Ford and Austin Chalk, as well as Haynesville formations located in Texas and Louisiana while maintaining a relentless focus on safety.
Commonwealth LNG was founded by industry veterans who decided to re-engineer the LNG construction model. Using proven best practices, Commonwealth is committed to building a world-class LNG export facility while focusing on safety, managing risk and achieving best-in-class environmental standards.
Job Description
Position Summary:
This position leads process safety and technical (major accident) risk management enterprise-wide, across both our US onshore upstream operations and Commonwealth LNG. The role provides the technical authority to ensure major accident hazards are systematically identified, assessed, reduced to As Low As Reasonably Practicable (ALARP), and controlled through a demonstrable system of barriers, and serves as custodian of the Commonwealth LNG safety case - a voluntary best-practice commitment, not a regulatory requirement - and of upstream process safety integrity and barrier management.
This position strengthens Caturus' safety culture by embedding robust process safety management, asset integrity, and barrier assurance throughout the asset lifecycle. The role has no direct reports and delivers through technical authority, influence, and the direction of specialist consultants and contractors. This role supports operations across all Caturus assets and will be located in Houston, TX, with travel to upstream facilities and the Commonwealth LNG terminal.
Key Accountabilities:
  • Own and continuously improve the corporate Process Safety Management (PSM) framework, aligned with OSHA PSM (29 CFR 1910.119) and EPA RMP (40 CFR 68) for our US onshore upstream operations, and with 49 CFR Part 193 / NFPA 59A for Commonwealth LNG.
  • Ensure all 14 PSM elements are implemented and sustained across upstream and LNG operations.
  • Serve as custodian of the Commonwealth LNG safety case, demonstrating that major accident hazards are identified and that adequate barriers and controls are in place and effective.
  • Define and maintain Safety-Critical Elements (SCEs) and their performance standards, and assure that preventive and mitigative barriers perform as claimed.
  • Lead and assure major-accident risk studies, including HAZID, HAZOP, LOPA, QRA, consequence modeling, facility siting and exclusion-zone analysis, and bow-tie analyses.
  • Lead upstream process safety integrity and barrier management against major accident events (loss of containment, blowout, well integrity loss).
  • Oversee Safety Instrumented Systems and functional safety to IEC 61511 / 61508, including SIL determination and verification.
  • Govern asset and mechanical integrity for safety-critical equipment, including anomaly, deferral, and override management.
  • Operate the Management of Change (MOC) process for changes affecting major accident risk, across plant, process, organizational, and procedural change.
  • Lead process safety incident and near-miss investigations and track corrective actions to closure.
  • Define and report leading and lagging process safety performance indicators in line with API RP 754 and IOGP guidance to leadership and the board.
  • Serve as the process safety interface with PHMSA, FERC, OSHA, and EPA, supporting permitting, inspections, and the FERC LNG authorization process.
  • Scope, direct, and quality-assure specialist consultants and contractors delivering process safety and technical risk work (QRA, consequence modeling, SIL studies, verification).
  • Ensure compliance with health, safety, and environmental policies, procedures, and documentation standards.

Qualifications
Education, Certificates, and Licenses:
  • Bachelor's degree required (Master's preferred) in Chemical, Process, Mechanical, or Safety Engineering, or a related field.
  • Professional registration (PE or Chartered Engineer) and/or process safety certification (e.g., CCPSC) strongly preferred.

Experience:
  • 10+ years of experience in process safety / technical safety within oil and gas required.
  • US onshore upstream (E&P) process safety experience required; global upstream experience preferred.
  • LNG process safety experience required.
  • Barrier management experience required, including definition and assurance of Safety-Critical Elements (SCEs) and performance standards.
  • Safety case experience required (must have) - demonstrated experience developing, maintaining, or defending a facility safety case.
  • Experience leading PHA/QRA studies and engaging regulators (PHMSA, FERC, OSHA) preferred.

Knowledge, Skills, and Abilities:
  • Deep knowledge of oil and gas process safety and technical (major accident) risk management across upstream and LNG.
  • Strong understanding of the LNG safety case regime and of upstream process safety integrity and barrier management (SCEs, performance standards, bow-ties).
  • Command of major-accident risk assessment techniques (HAZID, HAZOP, LOPA, QRA, consequence modeling) and ALARP demonstration.
  • Knowledge of OSHA PSM, EPA RMP, 49 CFR Part 193, NFPA 59A, and relevant API and IEC standards.
  • Ability to manage and direct specialist consultants and contractors, including scope definition and commercial control.
  • Strong leadership, communication, and influencing skills, with the credibility to challenge at all levels and hold technical authority.

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