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Systems Engineer Ii Jobs (NOW HIRING)

HomeTown Pharmacy Inc

Systems Engineer II

New Era, MI · On-site

Systems Engineer II Work Location: On-site New Era, Michigan HomeTown Pharmacy is a privately owned chain of pharmacies across Michigan, Indiana and Ohio serving, retail, long term care, infusion and ...

Saalex

Systems Engineer II

San Diego, CA · On-site

$95K - $160K/yr

Saalex Corporation is seeking multiple Systems Engineer II in Tidewater, VA and San Diego, CA. Saalex Corp., is an Engineering and Information Technology Services company with a focus on Test Range ...

Saalex

$95 - $160/hr

Saalex Corporation is seeking multiple Systems Engineer II positions in Tidewater, VA and San Diego, CA. Saalex Corp. is an Engineering and IT Services company focused on Test Range Operations ...

Saalex

Systems Engineer II

San Diego, CA · On-site

$95K - $160K/yr

Saalex Corporation is seeking multiple Systems Engineer II in Tidewater, VA and San Diego, CA. Saalex Corp., is an Engineering and Information Technology Services company with a focus on Test Range ...

Saalex Corp.

Systems Engineer II

San Diego, CA · On-site

$95 - $160/hr

Saalex Corporation is seeking multiple Systems Engineer II in Tidewater, VA and San Diego, CA. Saalex Corp., is an Engineering and Information Technology Services company with a focus on Test Range ...

Saalex

$95K - $160K/yr

Saalex Corporation is seeking multiple Systems Engineer II in Tidewater, VA and San Diego, CA. Saalex Corp., is an Engineering and Information Technology Services company with a focus on Test Range ...

TRILLIUM HEALTH RESOURCES

Systems Engineer II

NC · Remote

$68K - $95K/yr

Systems Engineer II Working Title: Systems Engineer II Position Number: 81162 FLSA Status: Exempt Posting Salary Range: $68,640 - $95,127 Office Location: Remote within North Carolina. POSTING ...

New

Saalex

$95K - $160K/yr

Saalex Corporation is seeking multiple Systems Engineer II in Tidewater, VA and San Diego, CA. Saalex Corp., is an Engineering and Information Technology Services company with a focus on Test Range ...

City of Henderson, NV

Systems Engineer II*

Henderson, NV · On-site

$83K - $125K/yr

Competitive Salary Range for Systems Engineer II $83,839.98 - $125,759.96 annually * Salary placement for non-represented positions is based on a comprehensive compensation review and takes into ...

City of Henderson

Systems Engineer II*

Henderson, NV

$83K - $125K/yr

Competitive Salary Range for Systems Engineer II $83,839.98 - $125,759.96 annually. Salary placement for non-represented positions is based on a comprehensive compensation review and takes into ...

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Systems Engineer Ii information

See salary details

$53.5K

$127.2K

$167K

How much do systems engineer ii jobs pay per year?

As of Sep 6, 2026, the average yearly pay for systems engineer ii in the United States is $127,215.00, according to ZipRecruiter salary data. Most workers in this role earn between $98,000.00 and $157,000.00 per year, depending on experience, location, and employer.

What does a Systems Engineer II do?

A Systems Engineer II is responsible for designing, implementing, and maintaining complex IT systems within an organization. They work on tasks such as configuring servers, troubleshooting network issues, and ensuring system security and performance. This role typically requires a few years of experience and involves collaborating with other IT professionals to support and optimize technological infrastructure. Systems Engineer IIs often participate in project planning, system upgrades, and provide technical support to end-users or other teams.

What are the key skills and qualifications needed to thrive as a Systems Engineer II?

To thrive as a Systems Engineer II, you need a strong background in systems architecture, troubleshooting, and a relevant degree in computer science or engineering. Familiarity with scripting languages, virtualization platforms, and certifications such as CompTIA, Microsoft, or Cisco are commonly required. Strong analytical skills, effective communication, and the ability to work collaboratively distinguish top performers in this role. These skills and qualities are crucial for ensuring reliable system operations, efficient problem resolution, and successful project delivery in complex IT environments.

What are the typical collaboration points for a Systems Engineer II within a technical team?

As a Systems Engineer II, you will frequently collaborate with software developers, network engineers, and IT support staff to ensure seamless integration and deployment of systems. You may participate in design meetings, contribute to troubleshooting sessions, and help document system configurations. This role often acts as a bridge between junior engineers and senior technical staff, making communication and teamwork vital for project success.

What is the difference between Systems Engineer Ii vs Systems Engineer I?

AspectSystems Engineer ISystems Engineer II
Required CredentialsBachelor's degree in IT, Computer Science, or related field; basic certifications like CompTIA Network+Same as Systems Engineer I, often with additional certifications like Cisco CCNA or Microsoft certifications
Work EnvironmentEntry-level, supporting IT infrastructure, troubleshooting, and system maintenanceMore complex projects, system design, and troubleshooting responsibilities
Employer & Industry UsageCommon in tech, finance, healthcare, and government sectorsSimilar industries, with increased expectations for independent problem-solving

Systems Engineer II typically has more experience and handles more complex tasks than Systems Engineer I, often requiring additional certifications and a deeper understanding of systems. They work in similar environments but are expected to operate more independently and contribute to larger projects.

What is the role of a Systems Engineer II?

A Systems Engineer II is responsible for designing, implementing, and maintaining complex IT systems and infrastructure. They troubleshoot technical issues, optimize system performance, and often work with tools like scripting languages and monitoring software. This role typically requires strong technical skills, problem-solving abilities, and relevant certifications such as CompTIA or Cisco.
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Systems Engineer Ii jobs near you
Infographic showing various Systems Engineer Ii job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 85% Full Time, 9% Part Time, 4% Contract, and 1% Nights. Highlights an 90% Physical, 2% Hybrid, and 8% Remote job distribution, with an average salary of $127,215 per year, or $61.2 per hour.

Systems Engineer II

Motion Recruitment

Santa Clara, CA

Contractor

Re-posted 16 days ago

Job description


Job Title: Systems Engineer II
Location: Santa Clara, CA 95050 (Onsite)
Duration: 12 Months with strong possibility of extension
Job Description:
The Sequencing team is seeking a passionate Systems Engineer II to join the Systems Integration Group supporting Next Generation Sequencing (NGS) products. This is a hands-on role in which the Systems Engineer II will contribute to feasibility, development, and integration activities for end-to-end NGS solutions.
As a member of the Systems Integration team, this individual will work with a Single Molecule Sequencing platform to optimize operating protocols, design and perform wet-lab experiments, support integration of system subcomponents, and help improve the overall sequencing solution.
Key Responsibilities
  • Design, execute, analyze, and document experiments to support feasibility, development, integration, verification, and validation of NGS workflows.
  • Perform sample preparation, library preparation, sequencing-related experiments, and verification studies.
  • Use the Single Molecule Sequencing platform to optimize final operating protocols and support system-level integration activities.
  • Interpret experimental results using appropriate experimental design and statistical analysis methods.
  • Troubleshoot instrument, workflow, or assay-related failures using standard root cause analysis methods.
  • Collaborate with subject matter experts to understand failure modes and identify appropriate solutions.
  • Develop, execute, and document test cases based on product requirements for verification and validation activities.
  • Maintain accurate, well-organized, and concise laboratory records using best laboratory practices.
  • Work cross-functionally with assay, instrumentation, software, bioinformatics, and systems teams to resolve integration challenges.
  • Support continuous improvement of sequencing performance, including coverage, throughput, robustness, reproducibility, and overall system reliability.
Required Qualifications
  • Bachelor's degree in chemistry, science, engineering, or a related field with 5 years of relevant experience, or a Master's degree in a related field with 1-3+ years of relevant experience.
  • Demonstrated hands-on experience with PCR, DNA sequencing methods, raw sample preparation, nucleic acid extraction, library preparation, and/or NGS sequencing.
  • At least 2 years of experience using MATLAB, Git, Python, or similar tools for data analysis and/or automation.
  • Experience with statistical tools and methods, such as Python, JMP, regression analysis, and ANOVA.
  • At least 2 years of experience with Design of Experiments methodology and application of statistical process control.
  • Demonstrated ability to troubleshoot technical issues and identify root causes in laboratory, instrument, or workflow settings.
  • Strong documentation skills and commitment to following best laboratory practices.
Preferred Qualifications
  • Proven track record of performing in a fast-paced, matrixed environment.
  • Ability to work independently while collaborating effectively across functions.
  • Demonstrated ability to influence technical decisions and stakeholders without direct authority.
  • Experience solving unique, ambiguous, or unpredictable problems that may impact project or organizational goals.
  • Strong planning, prioritization, multitasking, and follow-through skills.
  • Highly energetic, focused, and adaptable working style.
  • Strong interpersonal, verbal communication, and relationship-building skills.
  • Demonstrated ability to build and maintain effective relationships with key stakeholders.

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