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System Safety Engineer Jobs in Missouri (NOW HIRING)

Agile Defense

System Engineer (MBSE)

Saint Louis, MO · Hybrid

System Engineer (MBSE) Location: Hybrid, St Louis, MO Clearance Level: Secret, Must Have Clearance ... Perform analyses for affordability, safety, reliability, maintainability, testability ...

Orscheln Industries

Product Engineer

Moberly, MO · On-site

$64K/yr

... System Safety Analysis (MTBF, Maintainability, FMECA) o FMECA (Failure Modes Effects and ... Engineer must possess excellent written and verbal communication skills and be capable of ...

Orscheln Industries

Product Engineer

Moberly, MO

$64K/yr

... System Safety Analysis (MTBF, Maintainability, FMECA) o FMECA (Failure Modes Effects and ... Engineer must possess excellent written and verbal communication skills and be capable of ...

Orscheln Industries

Product Engineer

Moberly, MO · On-site

... System Safety Analysis (MTBF, Maintainability, FMECA) o FMECA (Failure Modes Effects and ... Engineer must possess excellent written and verbal communication skills and be capable of ...

BioFire Diagnostics

Lead System Engineer

Hazelwood, MO

$150K - $205K/yr

Is accountable for the technical engineering aspects of R&D projects assuring proper documentation, respect of good scientific, quality and safety procedures, with a focus on system integration.

Biomerieux

Lead System Engineer

Hazelwood, MO · On-site

$150K - $205K/yr

Is accountable for the technical engineering aspects of R&D projects assuring proper documentation, respect of good scientific, quality and safety procedures, with a focus on system integration.

bioMerieux

Lead System Engineer

Hazelwood, MO

$150K - $205K/yr

Is accountable for the technical engineering aspects of R&D projects assuring proper documentation, respect of good scientific, quality and safety procedures, with a focus on system integration.

bioMérieux

Lead System Engineer

Hazelwood, MO · On-site

$150K - $205K/yr

Is accountable for the technical engineering aspects of R&D projects assuring proper documentation, respect of good scientific, quality and safety procedures, with a focus on system integration.

Jobgether

$37 - $74/hr

Our partner is looking for a Senior Safety Methods Engineer based in Netherlands. This role ... Develop system-level thermal-hydraulic analysis methods, including modeling strategies, numerical ...

U.S. Engineering

Safety Coordinator

Kansas City, MO · On-site

Engineering Service. We deliver award-winning mechanical contracting, construction, service, and ... Proficiency in Microsoft Office Suite; familiarity with safety or service management systems ...

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System Safety Engineer information

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How much do system safety engineer jobs pay per hour?

As of Aug 8, 2026, the average hourly pay for system safety engineer in Missouri is $62.74, according to ZipRecruiter salary data. Most workers in this role earn between $50.96 and $74.18 per hour, depending on experience, location, and employer.

What is a system safety engineer?

System Safety Engineers are professionals responsible for identifying, assessing, and mitigating risks associated with complex systems to ensure they operate safely and reliably. They analyze potential hazards, design safety protocols, and work closely with engineering teams to implement safety standards throughout the lifecycle of a product or system. Their work is critical in industries such as aerospace, automotive, defense, and energy, where system failures can have significant consequences. System Safety Engineers often use specialized tools and methodologies, such as hazard analysis and risk assessment, to support safety and regulatory compliance.

What are some common challenges system safety engineers face when working on multidisciplinary projects?

System Safety Engineers often work with cross-functional teams that include design, operations, and software professionals. A key challenge is ensuring that safety requirements are clearly communicated and integrated throughout all phases of system development. Balancing safety goals with project constraints like budget and timeline can also be demanding, as can managing the documentation and verification processes across different engineering disciplines. Success in this role requires strong collaboration and communication skills, as well as a proactive approach to identifying and mitigating potential safety hazards.

What is the difference between System Safety Engineer vs Reliability Engineer?

AspectSystem Safety EngineerReliability Engineer
Required CertificationsISO 26262, MIL-STD-882, PE licenseSix Sigma, Certified Reliability Engineer (CRE)
Work EnvironmentManufacturing, aerospace, automotive, defenseManufacturing, aerospace, electronics, energy
Employer & Industry UsageSafety-critical systems, risk mitigationProduct durability, failure analysis

While both roles focus on system performance, the System Safety Engineer emphasizes identifying and mitigating safety risks in complex systems, often working with safety standards and compliance. The Reliability Engineer concentrates on ensuring product reliability and longevity, analyzing failure modes and improving system durability. Both roles are vital in safety-critical industries but serve distinct functions in system development and maintenance.

What are the key skills and qualifications needed to thrive as a system safety engineer, and why are they important?

To thrive as a System Safety Engineer, you need a solid background in engineering principles, risk assessment, and safety analysis, usually supported by a degree in engineering or a related field. Familiarity with safety-critical standards (such as MIL-STD-882 or ISO 26262), hazard analysis tools, and systems modeling software is typically required. Strong analytical thinking, attention to detail, and effective communication skills help you excel in cross-functional teams. These skills are essential to proactively identify and mitigate risks, ensuring the safe and reliable operation of complex systems.

What does a system safety engineer do?

A system safety engineer helps to develop, refine, and update safety protocols and software that controls a large system and ensures that even if aspects of the system fail, it does not put the entire system at jeopardy. For example, if a subsystem on a spaceship fails, your duties as a system safety engineer are to determine how to make sure that it does not affect other systems or endanger the critical life support systems. Systems safety engineering is essential in a wide range of fields, from civil engineering and aeronautics to software and hardware engineering and power plant systems.

More about System Safety Engineer jobs
What are the most commonly searched types of System Safety Engineer jobs in Missouri? The most popular types of System Safety Engineer jobs in Missouri are:
What are popular job titles related to System Safety Engineer jobs in Missouri? For System Safety Engineer jobs in Missouri, the most frequently searched job titles are:
What job categories do people searching System Safety Engineer jobs in Missouri look for? The top searched job categories for System Safety Engineer jobs in Missouri are:
What are popular job titles related to System Safety Engineer jobs in MO? For System Safety Engineer jobs in MO, the most frequently searched job titles are:
System Safety Engineer jobs near you
Infographic showing various System Safety Engineer job openings in Missouri as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 99% Physical, and 1% Remote job distribution, with an average salary of $130,496 per year, or $62.7 per hour.

System Engineer (MBSE)

Agile Defense

Saint Louis, MO • Hybrid

Full-time

Re-posted 4 days ago

Job description

About Agile Defense
 
At Agile Defense we know that action defines the outcome and new challenges require new solutions. That's why we always look to the future and embrace change with an unmovable spirit and the courage to build for what comes next.
 
Our vision is to bring adaptive innovation to support our nation's most important missions through the seamless integration of advanced technologies, elite minds, and unparalleled agility-leveraging a foundation of speed, flexibility, and ingenuity to strengthen and protect our nation's vital interests.

Requisition #: 1647
Job Title: System Engineer (MBSE)
Location: Hybrid, St Louis, MO
Clearance Level: Secret, Must Have Clearance to Start
Job Description

This position Applies a collaborative, interdisciplinary systems engineering approach to plan, design, develop, integrate, and verify complex systems and system-of-systems solutions throughout the lifecycle. Analyzes customer and operational requirements to define system performance, ensure compatibility across technical and program interfaces, and optimize overall system architecture. Conducts engineering analyses to support affordability, reliability, maintainability, safety, cybersecurity, certification, and mission assurance objectives. Leads requirements management, risk and issue management, technology readiness assessments, and systems engineering processes while resolving cross-functional technical challenges to ensure successful mission outcomes.

  • Perform analysis to optimize total system and/or system architecture to solve complex mission planning problems.
  • Apply interdisciplinary, collaborative approaches to plan, design, develop and verify system solutions.
  • Define and coordinate system performance requirements and integrate technical parameters.
  • Define high level functional and performance requirements and verification methods, subsequent analysis, decomposition, and derivation of requirements, allocation of those lower-level requirements to physical and functional architectural elements, and tracking them through design, verification, integration, and operational validation.
  • Perform analyses for affordability, safety, reliability, maintainability, testability, survivability, human systems integration, survivability, vulnerability, susceptibility, system security, regulatory, certification, product assurance, product security (cyber security) and other specialties quality factors into a preferred configuration to ensure mission success.
  • Utilization of Model-Based Systems Engineering (MBSE) tools such as Cameo, and mathematical modeling and simulation to develop system definitions and perform trade studies in assigned areas
  • Perform risk assessments and generate mitigation plans for various programs with regard to compliance with system requirements and customer capabilities
  • Develop verification and validation methods, processes, logic, and plans in support of program milestones.
  • Develop and document software system requirements
  • Analyze and translate requirements into system architecture, hardware and software designs and interface specifications
  • Test and validate to ensure system designs meet operational and functional requirements.
Education and Background
  • Bachelor, Master or Doctorate of Science degree from an accredited course of study, in Computer Engineering, Software Engineering, Computer Science, Mathematics, or other technical degreeExperience with software configuration management tools such as Team Foundation Server/Azure DevOps
  • Experience writing and analyzing test procedures and software requirements
  • Experience with OFP (Operational Flight Program) SIL (System Integration Lab) testing
Years of Experience
5+ years 
Required Skills
5+ years of experience in system engineering, 1+ years of experience with Scaled Agile Framework or Agile Methodologies
Working Conditons
Typical office environment.
Our Core Values
 
Employees of Agile Defense are our number one priority, and the importance we place on our culture here is fundamental. Our culture is alive and evolving, but it always stays true to its roots. Here, you are valued as a family member, and we believe that we can accomplish great things together. Agile Defense has been highly successful in the past few years due to our employees and the culture we create together. 
 
What makes us Agile? We call it the 6Hs, the values that define our culture and guide everything we do. Together, these values infuse vibrancy, integrity, and a tireless work ethic into advancing the most important national security and critical civilian missions. It's how we show up every day. It's who we are.
 
  • Happy - Be Infectious. Happiness multiplies and creates a positive and connected environment where motivation and satisfaction have an outsized effect on everything we do.
  • Helpful - Be Supportive. Being helpful is the foundation of teamwork, resulting in a supportive atmosphere where collaboration flourishes, and collective success is celebrated.
  • Honest - Be Trustworthy. Honesty serves as our compass, ensuring transparent communication and ethical conduct, essential to who we are and the complex domains we support.
  • Humble - Be Grounded. Success is not achieved alone, humility ensures a culture of mutual respect, encouraging open communication, and a willingness to learn from one another and take on any task.
  • Hungry - Be Eager. Our hunger for excellence drives an insatiable appetite for innovation and continuous improvement, propelling us forward in the face of new and unprecedented challenges.
  • Hustle - Be Driven. Hustle is reflected in our relentless work ethic, where we are each committed to going above and beyond to advance the mission and achieve success.
 
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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