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Sr Manager It Operations Jobs (NOW HIRING)

Ironclad

Senior Manager, IT Operations

San Francisco, CA · On-site

$175K - $216K/yr

Senior Manager, IT Operations What You'll Do * Lead and develop the IT Operations function, including coaching and growing a team of IT engineers and contractors, setting clear priorities, and ...

Ro

Senior Manager, IT Operations

New York, NY

$179K - $213K/yr

The Role As Senior Manager, IT Operations, you are the architect of a frictionless employee experience. You own the reliability and quality of IT service delivery, ensuring that as Ro scales, our ...

TPC Group

Senior Manager, Information Technology

Houston, TX · On-site

$125K - $125K/yr

The Sr. Manager of Information Technology has full responsibility for all aspects of the ... Plans, oversees the designs and directs operational activities of the IT department, as well as ...

Nutanix

Manager, IT Operations- AMER

San Jose, CA · On-site

$104K - $207K/yr

You will report to the Sr. Manager - Global IT Operations, who is known for their hands-on leadership style that emphasizes collaboration and team empowerment. This role is classified as hybrid ...

ICON

Manager, IT Operations (Labs)

Farmingdale, NY · On-site

IT Operations Manager- Labs ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster. As a values ...

Icon plc

Manager, IT Operations (Labs)

Farmingdale, NY · On-site

IT Operations Manager- Labs ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster. As a values ...

NAC Inc

IT Operations Director

Los Angeles, CA · On-site

$149K - $174K/yr

The IT Operations Director is responsible for the day-to-day delivery of IT services at NAC ... senior management or director-level role in IT. · 7+ years of team and project management ...

NAC Architecture

IT Operations Director

Spokane, WA

$124K - $145K/yr

Description The IT Operations Director is responsible for the day-to-day delivery of IT services at ... a senior management or director-level role in IT. 7+ years of team and project management ...

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Sr Manager It Operations information

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$39K

$98.7K

$159.5K

How much do sr manager it operations jobs pay per year?

As of Jun 12, 2026, the average yearly pay for sr manager it operations in the United States is $98,723.00, according to ZipRecruiter salary data. Most workers in this role earn between $73,000.00 and $121,500.00 per year, depending on experience, location, and employer.

What does a Sr Manager IT Operations do?

A Sr Manager IT Operations oversees the daily operations of an organization's IT infrastructure, ensuring systems are reliable, secure, and efficient. They manage IT teams, set operational policies, and coordinate the deployment, maintenance, and support of hardware, software, and networks. Additionally, they often collaborate with other departments to align IT services with business objectives, manage budgets, and drive process improvements. Their role is crucial in minimizing downtime, ensuring cybersecurity, and supporting business growth through technology.

How does a Sr Manager IT Operations typically collaborate with other departments to ensure seamless technology integration?

A Sr Manager IT Operations regularly works with various departments—such as finance, HR, and business units—to understand their technology needs and ensure that IT systems support overall business objectives. This collaboration often involves attending cross-functional meetings, translating technical requirements for non-technical stakeholders, and coordinating project rollouts or updates. Building strong relationships with department heads helps anticipate challenges and ensures that IT solutions are aligned with organizational goals. Effective communication and stakeholder management are essential skills in this role.

What are the key skills and qualifications needed to thrive as a Sr Manager IT Operations, and why are they important?

To thrive as a Sr Manager IT Operations, you need strong expertise in IT infrastructure, service management, and leadership, often supported by a bachelor’s degree in computer science or a related field. Experience with ITIL frameworks, cloud platforms, network management tools, and relevant certifications like ITIL or PMP is typically required. Outstanding problem-solving, communication, and team leadership skills help drive operational excellence and foster cross-departmental collaboration. These competencies are crucial for ensuring reliable IT services, managing risk, and aligning technology initiatives with business goals.

What is the difference between Sr Manager It Operations vs IT Project Manager?

AspectSr Manager It OperationsIT Project Manager
CredentialsBachelor's degree, often with certifications like ITIL, PMPBachelor's degree, PMP or similar project management certifications
Work EnvironmentOversees IT infrastructure, support teams, and daily operationsManages specific IT projects from initiation to completion
Employer & Industry UsageCommon in large organizations managing ongoing IT servicesFound across industries managing project-based IT initiatives
Search & Comparison IntentOften compared for leadership roles in IT operationsCompared for project management roles in IT

The Sr Manager It Operations focuses on managing ongoing IT services and infrastructure, ensuring operational efficiency. In contrast, an IT Project Manager handles specific projects with defined goals and timelines. While both roles require strong IT knowledge and certifications, their primary responsibilities and work focus differ significantly.

More about Sr Manager It Operations jobs
What cities are hiring for Sr Manager It Operations jobs? Cities with the most Sr Manager It Operations job openings:
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Sr Manager It Operations jobs near you
Infographic showing various Sr Manager It Operations job openings in the United States as of June 2026, with employment types broken down into 86% Full Time, and 14% Contract. Highlights an 86% In-person, and 14% Hybrid job distribution, with an average salary of $98,723 per year, or $47.5 per hour.
Senior Manager, IT Operations

Senior Manager, IT Operations

C4 Therapeutics Inc

Watertown, MA • On-site

$171K - $190K/yr

Full-time

Posted 14 days ago

Job description

About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.

Job Summary

As C4T’s Senior Manager, IT Operations, you will oversee the day-to-day operation of our business-critical applications and IT infrastructure (both cloud and on-premises) while developing the long-term strategy for these systems. In this role, you will ensure high availability, performance, and reliability of all IT services, driving standardization, enhancing monitoring processes, and fostering a culture of continuous improvement. Additionally, you will strengthen and mature IT operational processes, compliance controls, and change management practices to maintain a stable and secure technology ecosystem during a critical growth phase as we advance through late-stage clinical trials. You will also lead the IT Operations team managing direct reports and coordinating with external IT support vendors to deliver efficient support and robust IT services across the organization. Your passion for customer service and for building strong, detail-oriented IT ways of working, cultures, and teams will be key as you play a key role in the evolution of C4T’s information technology infrastructure and operations.


Your Role

  • Oversee and execute daily operations of enterprise applications, infrastructure services, IT support, day-to-day environments (cloud/on-prem).
  • Lead, train, coach, develop and retain personnel on the IT team as assigned, cultivating a high-performance, accountable IT team culture.
  • Implement and continuously improve standardized IT operational processes, including establishing effective monitoring and alerting systems, increasing automation of routine tasks, and maintaining up-to-date documentation for all operational procedures.
  • Own and mature change management workflows, ensuring compliance with GxP, SOX, and internal standards for systems under compliance scope such as NetSuite and Veeva, ensuring that infrastructure and application environments maintain strong security, compliance, and audit readiness.
  • Direct the operation and support of core enterprise applications and collaboration platforms, particularly those in the Microsoft 365 ecosystem (including Microsoft Entra ID/Azure AD, Intune, SharePoint, Teams, etc.), ensuring that these systems are well-integrated, secure, aligned, and evolving with business needs.
  • Build and maintain effective relationships with vendors, application, service, and project owners ensuring IT operations provide reliable service, timely incident resolution, and meet SLAs, aligning IT operations initiatives with broader business objectives and needs.

Your Background

Required:

  • A minimum of ten years of IT experience, with at least five years in IT roles within a Life Science setting (pharmaceutical, biotechnology, or vendor) overseeing critical business applications, systems, and infrastructure and enforcing uptime and performance standards, including previous managerial experience.
  • Strong background overseeing, maintaining, and evolving IT infrastructure (both cloud and on-premises) environments with proven IT operations execution experience across applications, SaaS platforms, infrastructure, and service desk domain, with experience driving, evolving and implementing automation, maintenance, within IT operational processes and systems.
  • Knowledge of operational best practices, including ITIL, Change Management, SOP development, and compliance control maturation with demonstrated success managing and implementing related processes to drive evolution.
  • Proven track record of vendor management responsibilities, including identifying potential technology partners, generating RFPs, reviewing SOWs and MSAs, defining performance metrics and ensuring mutual accountability for the partnership in collaboration with Procurement, Legal, and Finance teams.
  • Familiarity and expertise operating within Quality and Compliance frameworks, such as GxP, SOX, and data integrity principles.

Preferred:

  • Hands on experience operating in late-stage clinical or commercial stage biopharma environments.
  • Working knowledge of the Veeva modules utilized for document management, regulatory submissions, and Quality events.
  • Implementation of AI tools to optimize organizational efficiency and productivity without compromising data security or integrity.
  • Proficiency with common cybersecurity frameworks and best practices.

Compensation

The base pay range for this position at commencement of employment is expected to be between $171,782.00 and $190,340.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.


C4 Therapeutics is an Equal Opportunity Employer.