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Senior Variant Scientist Jobs (NOW HIRING)

Baylor Genetics

Clinical Genomic Scientist - WGS

This position involves clinical documentation review, case analysis, candidate variant selection ... Clinical Genomic Scientist - WGS review - Senior * 7 years of experience with whole exome or whole ...

Integrated Resources, Inc

Sr. Scientist

San Diego, CA · On-site

$40 - $43/hr

Title: Sr. Scientist Location: San Diego, CA ( Onsite) Duration: 8 Months W2 contract with high ... variant analysis, particle analysis, CE-SDS, and other physical-property characterization. The ...

New

Variant Bio

Executive Administrator

Seattle, WA · Hybrid

... biotech, life sciences, or venture-backed company. Given the dynamic nature of a startup ... QUALIFICATIONS Must Have... * 5+ years of experience supporting C-suite or senior executives (CEO, ...

Ampersand

Senior Scientist I, Microfluidics

Boston, MA · On-site

$99K - $135K/yr

The Role Ampersand Biomedicines is seeking a Senior Scientist I to help build and apply cell-based, high-throughput capabilities for engineered antibody and protein variant library screening. This ...

Natera

Senior Bioinformatics Scientist

$117K - $146K/yr

Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics Research team and ... variant calling workflows. * Experience in algorithm development and data analysis, including ...

Triveni Bio

Director, AI and Data Science

Watertown, MA · On-site

$240K - $255K/yr

Lead human genetics analyses, including human genetics scoring, variant interpretation, and ... scientists to senior leaders * Self-starter mindset: Comfortable with ambiguity; able to ...

Natera

Senior Bioinformatics Scientist

San Carlos, CA · On-site

$130K - $163K/yr

Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics Research team and ... variant calling workflows. * Experience in algorithm development and data analysis, including ...

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Senior Variant Scientist information

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How much do senior variant scientist jobs pay per year?

As of Sep 13, 2026, the average yearly pay for senior variant scientist in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What is a senior variant scientist?

Senior Variant Scientists are specialized professionals in genetics and genomics who analyze and interpret genetic variants, often from DNA sequencing data. They play a critical role in clinical diagnostics, research, and precision medicine by determining which genetic changes are associated with disease. Their work involves reviewing scientific literature, using bioinformatics tools, and collaborating with clinicians to provide accurate variant classifications. Senior Variant Scientists typically have advanced degrees in genetics or related fields and several years of experience in genetic analysis.

How do senior variant scientists typically collaborate with other teams during the process of variant interpretation and reporting?

Senior Variant Scientists play a pivotal role in multidisciplinary teams by collaborating closely with clinical geneticists, bioinformaticians, and laboratory technicians. They often participate in variant review meetings, contribute expert opinions during case discussions, and help refine protocols for variant classification. Regular communication ensures that data interpretation aligns with clinical guidelines, and that reporting is accurate and actionable. This collaborative environment supports high-quality results and continuous learning, offering opportunities for leadership and cross-functional project involvement.

What are the key skills and qualifications needed to thrive as a senior variant scientist, and why are they important?

To thrive as a Senior Variant Scientist, you need a deep understanding of molecular genetics, genomic data analysis, and variant interpretation, typically supported by a PhD or equivalent experience in genetics or related fields. Proficiency with bioinformatics tools (such as GATK, ANNOVAR, or VEP), next-generation sequencing platforms, and familiarity with clinical databases like ClinVar are crucial. Strong problem-solving, analytical thinking, and effective communication skills distinguish top performers in this role. These competencies are vital for delivering accurate variant assessments that guide clinical decision-making and advance research in genomics.
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Senior Variant Scientist jobs near you
Infographic showing various Senior Variant Scientist job openings in the United States as of September 2026, with employment types broken down into 100% Full Time. Highlights an 82% In-person, and 18% Remote job distribution, with an average salary of $110,545 per year, or $53.1 per hour.

Genomics Sr Staff Scientist

Palo Alto, CA • On-site

Stanford Health Care
See more jobs at Stanford Health Careexternal

Full-time

Re-posted 2 days ago

Job description

If you're ready to be part of our legacy of hope and innovation, we encourage you to take the first step and explore our current job openings. Your best is waiting to be discovered.
Day - 08 Hour (United States of America)
This is a Stanford Health Care job.
A Brief Overview
As a member of the Clinical Laboratory team, the Genomic Senior Staff Scientist will collaborate with a diverse team including laboratory directors, genetic counselors, laboratory technologists, bioinformaticians, and clinicians, who work together to provide clinical genetic and genomic test results.
Within this team, the Genomic Senior Staff Scientist is responsible for variant prioritization and interpretation derived from clinical sequencing data, i.e. evaluating the clinical relevance of genetic variants identified by clinical diagnostic tests using appropriate internal and external guidelines, including relevant evidence obtained from the scientific literature. Additional responsibilities include, but are not limited to, drafting clinical reports, contributing to quality and process improvement or development projects, assisting in the design, development and evaluation of new clinical-grade molecular diagnostic tests, evaluating and implementing evolving variant interpretation standards and workflows, and assisting in onboarding new team members.
Locations
Stanford Health Care
What you will do
  • Identify clinically significant sequence variants (germline and/or somatic), using established tools and workflows
  • Collect genetic, clinical, and molecular information from peer-reviewed scientific journals and public data sources
  • Critically analyze and verify the accuracy of published data and abstract information relevant to individual clinical case analyses
  • Review patient medical records and abstract information relevant to individual clinical case analyses
  • Independently classify clinically significant sequence variants (germline and/or somatic)
  • Summarize results of analyses and effectively communicate results in both written and verbal formats
  • Meet interpretation turn-around times required in a clinical laboratory setting to provide prompt patient care. Demonstrate efficiency in daily tasks to complete assigned volume within the target turn-around time.
  • Proactively identify or volunteer to address production pressure points and take on projects to improve workplace productivity
  • Participate in the development of new clinical-grade genetic tests and/or enhancements of existing assays
  • Assist in clinical validation of new tests and workflow updates
  • Assist in the development or integration of new analysis systems, software tools, and workflows for new and existing laboratory tests
  • Identify and report errors or inconsistencies in analysis tools or online resources
  • Participate in software system verification and other quality improvement projects. Create verification documentation and SOP documentation drafts. Provide suggestions and feedback for SOP improvements of existing tests
  • Lead the implementation of productivity enhancements
  • Curate genes for new test development (Mendelian (germline) and/or oncology (somatic)
  • Contribute to preparations for audits (documentation, quality monitoring, etc.) to meet CAP/CLIA requirements
  • Create reference or training resource materials
  • Consistently adhere to C-I-CARE standards in all interactions with team members and external collaborators. Collaborate to resolve misunderstandings and issues early before they impact timelines, team spirit or morale

Education Qualifications
  • PhD or MS in Molecular Biology, Genetics, or a related discipline/field, from an accredited college or university.

Experience Qualifications
  • Four (4) or more years of work experience in the field of genetics or cancer genetics, or combination of relevant experiences.
  • One (1) year or more of work experience in a CLIA-certified clinical laboratory performing diagnostic testing.
  • Of the above, at least one (1) year experience must be with NGS-based tests and at least one (1) year experience in germline or cancer diagnostic testing.

Required Knowledge, Skills and Abilities
  • Experience in next generation sequencing and classification/curation of variants
  • Ability to understand scientific literature and experimental procedures, as well as the limitations and applications of this information in a clinical setting. Experience in critically evaluating genetic data, research publications and online resources
  • Experience in databases, tools, and resources commonly used in human or model organism genetics and genomics required (e.g. ClinVar/ClinGen, gnomAD, ExAC, HGMD, COSMIC)
  • Experience working in multidisciplinary team-based projects
  • Ability to propose/identify and lead the implementation of significant productivity enhancements, particularly changes to decrease turnaround times and/or reduce costs
  • Change management champion
  • Detail-orientation with strong analytical skills
  • Computer skills, including word processing and spreadsheet applications
  • Strong written and oral English communication skills
  • Experience with databases, tools, and resources (e.g. ClinVar, gnomAD, ExAC, HGMD, COSMIC ) commonly used in human or model organism genetics and genomics required
  • Experience in variant interpretation in a clinical genetic testing laboratory required
  • Experience working both independently and on team-based projects
  • Perform day-to-day operations independently with little assistance from other team members or laboratory directors
  • Participate in clinical validation of a new test or update to existing test with minimal supervision. Create validation documentation and SOP documentation drafts requiring minimal corrections

Preferred Knowledge, Skills and Abilities
  • Knowledge to independently design and complete clinical validations, as well as oversee development and drafting of validation and SOP documentation.
  • Excellent communication skills (oral and written), attention to detail, problem-solving ability
  • Clear understanding of CAP requirements

Licenses and Certifications
  • None

These principles apply to ALL employees:
SHC Commitment to Providing an Exceptional Patient & Family Experience
Stanford Health Care sets a high standard for delivering value and an exceptional experience for our patients and families. Candidates for employment and existing employees must adopt and execute C-I-CARE standards for all of patients, families and towards each other. C-I-CARE is the foundation of Stanford's patient-experience and represents a framework for patient-centered interactions. Simply put, we do what it takes to enable and empower patients and families to focus on health, healing and recovery.
You will do this by executing against our three experience pillars, from the patient and family's perspective:
  • Know Me: Anticipate my needs and status to deliver effective care
  • Show Me the Way: Guide and prompt my actions to arrive at better outcomes and better health
  • Coordinate for Me: Own the complexity of my care through coordination

Equal Opportunity Employer Stanford Health Care (SHC) strongly values diversity and is committed to equal opportunity and non-discrimination in all of its policies and practices, including the area of employment. Accordingly, SHC does not discriminate against any person on the basis of race, color, sex, sexual orientation or gender identity and/or expression, religion, age, national or ethnic origin, political beliefs, marital status, medical condition, genetic information, veteran status, or disability, or the perception of any of the above. People of all genders, members of all racial and ethnic groups, people with disabilities, and veterans are encouraged to apply. Qualified applicants with criminal convictions will be considered after an individualized assessment of the conviction and the job requirements.
Base Pay Scale: Generally starting at $66.52 - $88.14 per hour
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training. This pay scale is not a promise of a particular wage.

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