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Senior Variant Scientist Jobs (NOW HIRING)

Nationwide Children's Hospital

Accurately identifies, classifies, and documents variants following practice guidelines under the direction of the Laboratory Directors and Senior and Lead Variant Scientists. Assists with the day-to ...

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How much do senior variant scientist jobs pay per year?

As of May 29, 2026, the average yearly pay for senior variant scientist in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Variant Scientist, and why are they important?

To thrive as a Senior Variant Scientist, you need a deep understanding of molecular genetics, genomic data analysis, and variant interpretation, typically supported by a PhD or equivalent experience in genetics or related fields. Proficiency with bioinformatics tools (such as GATK, ANNOVAR, or VEP), next-generation sequencing platforms, and familiarity with clinical databases like ClinVar are crucial. Strong problem-solving, analytical thinking, and effective communication skills distinguish top performers in this role. These competencies are vital for delivering accurate variant assessments that guide clinical decision-making and advance research in genomics.

How do Senior Variant Scientists typically collaborate with other teams during the process of variant interpretation and reporting?

Senior Variant Scientists play a pivotal role in multidisciplinary teams by collaborating closely with clinical geneticists, bioinformaticians, and laboratory technicians. They often participate in variant review meetings, contribute expert opinions during case discussions, and help refine protocols for variant classification. Regular communication ensures that data interpretation aligns with clinical guidelines, and that reporting is accurate and actionable. This collaborative environment supports high-quality results and continuous learning, offering opportunities for leadership and cross-functional project involvement.

What are Senior Variant Scientists?

Senior Variant Scientists are specialized professionals in genetics and genomics who analyze and interpret genetic variants, often from DNA sequencing data. They play a critical role in clinical diagnostics, research, and precision medicine by determining which genetic changes are associated with disease. Their work involves reviewing scientific literature, using bioinformatics tools, and collaborating with clinicians to provide accurate variant classifications. Senior Variant Scientists typically have advanced degrees in genetics or related fields and several years of experience in genetic analysis.
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What cities are hiring for Senior Variant Scientist jobs? Cities with the most Senior Variant Scientist job openings:
What are the most commonly searched types of Variant Scientist jobs? The most popular types of Variant Scientist jobs are:
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What job categories do people searching Senior Variant Scientist jobs look for? The top searched job categories for Senior Variant Scientist jobs are:
Senior Variant Scientist jobs near you
Infographic showing various Senior Variant Scientist job openings in the United States as of May 2026, with employment types broken down into 1% As Needed, 96% Full Time, and 3% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $110,545 per year, or $53.1 per hour.
Variant Assessment Scientist II- Oncology (REMOTE, USA)

Variant Assessment Scientist II- Oncology (REMOTE, USA)

Ambry Genetics

Remote

$112K - $120K/yr

Full-time

Posted 9 days ago

Job description

Compensation:

$112,000-$120,000

Variant Assessment Scientist II (Oncology): Remote USA

Job Overview:

Responsibilities include variant analysis of diagnostic molecular genetic test results; evaluation of published literature, clinical data and review of both functional and in silico data to provide accurate, thorough, and thoughtful clinical interpretation of results. Write research articles in collaboration with other medical professionals and colleagues outside and inside the organization, if data is relevant to the scientific community. Additional responsibilities as designated by supervisor/manager and/or with increasing seniority (Senior Variant Assessment Scientist).

Duties and Responsibilities:

  • Write and interpret molecular test results, including relevant medical literature reviews and summary.

  • Participate in updating variant classification guidelines and developing gene specific classification guidelines.

  • Research novel ways to assess sequence variants.

  • Manage and follow guidelines of variant pre-classification workflow to maximize reporting results within published turn-around times.

  • Train new variant team members or clinical team.

Education and Knowledge:

  • PhD and/or MD with expertise in molecular genetics, human genetics, molecular pathology or related field. MS in molecular biology, genetics or related field with exceptional expertise and outstanding job performance may also be considered

Technical Competencies:

  • Thorough and ongoing knowledge of current theories and principles of human genetics. Excellent written and verbal communication skills to convey difficult information in a clear, kind, and respectful manner. Willingness and ability to work in and contribute to a fast-paced, highly collaborative environment.

Experience:

  • Prior experience in variant assessment and reporting specialty preferred.

  • Minimum +2 years of experience with variant assessment.

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