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Senior Variant Scientist Jobs (NOW HIRING)

Nationwide Children's Hospital

Accurately identifies, classifies, and documents variants following practice guidelines under the direction of the Laboratory Directors and Senior and Lead Variant Scientists. Assists with the day-to ...

Quest Diagnostics

Sr. Scientist (NGS/LRS)

Marlborough, MA · On-site

$103K/yr

The senior scientist will lead the design and execution of complex development projects, ensuring ... Deep understanding of genomics and genetics, including variant interpretation and solutioning for ...

Variant Bio

Senior Security Engineer

Seattle, WA · On-site

$184K - $241K/yr

Variant Bio is developing life-saving therapies by studying the genes of people with exceptional ... S. in Computer Science or related field, or equivalent experience. * 8+ years designing and ...

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Variant Bio

Senior Security Engineer

Seattle, WA · On-site

$184K - $241K/yr

ABOUT THE ROLE At Variant Bio, protecting the data entrusted to us by our partner communities is ... S. in Computer Science or related field, or equivalent experience. * 8+ years designing and ...

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Senior Variant Scientist information

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How much do senior variant scientist jobs pay per year?

As of Jul 14, 2026, the average yearly pay for senior variant scientist in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What are Senior Variant Scientists?

Senior Variant Scientists are specialized professionals in genetics and genomics who analyze and interpret genetic variants, often from DNA sequencing data. They play a critical role in clinical diagnostics, research, and precision medicine by determining which genetic changes are associated with disease. Their work involves reviewing scientific literature, using bioinformatics tools, and collaborating with clinicians to provide accurate variant classifications. Senior Variant Scientists typically have advanced degrees in genetics or related fields and several years of experience in genetic analysis.

How do Senior Variant Scientists typically collaborate with other teams during the process of variant interpretation and reporting?

Senior Variant Scientists play a pivotal role in multidisciplinary teams by collaborating closely with clinical geneticists, bioinformaticians, and laboratory technicians. They often participate in variant review meetings, contribute expert opinions during case discussions, and help refine protocols for variant classification. Regular communication ensures that data interpretation aligns with clinical guidelines, and that reporting is accurate and actionable. This collaborative environment supports high-quality results and continuous learning, offering opportunities for leadership and cross-functional project involvement.

What are the key skills and qualifications needed to thrive as a Senior Variant Scientist, and why are they important?

To thrive as a Senior Variant Scientist, you need a deep understanding of molecular genetics, genomic data analysis, and variant interpretation, typically supported by a PhD or equivalent experience in genetics or related fields. Proficiency with bioinformatics tools (such as GATK, ANNOVAR, or VEP), next-generation sequencing platforms, and familiarity with clinical databases like ClinVar are crucial. Strong problem-solving, analytical thinking, and effective communication skills distinguish top performers in this role. These competencies are vital for delivering accurate variant assessments that guide clinical decision-making and advance research in genomics.
More about Senior Variant Scientist jobs
What cities are hiring for Senior Variant Scientist jobs? Cities with the most Senior Variant Scientist job openings:
What are the most commonly searched types of Variant Scientist jobs? The most popular types of Variant Scientist jobs are:
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Senior Variant Scientist jobs near you
Infographic showing various Senior Variant Scientist job openings in the United States as of July 2026, with employment types broken down into 1% As Needed, 91% Full Time, 5% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $110,545 per year, or $53.1 per hour.
Clinical Genomics Variant Scientist - Next Generation Seq

Clinical Genomics Variant Scientist - Next Generation Seq

Nationwide Children's Hospital

Columbus, OH • On-site

Full-time

Re-posted 26 days ago

Nationwide Children's Hospital rating

6.9

Company rating: 6.9 out of 10

Based on 129 frontline employees who took The Breakroom Quiz

531st of 1,020 rated hospitals

Job description

Overview:
Job Description Summary:
Accurately identifies, classifies, and documents variants following practice guidelines under the direction of the Laboratory Directors and Senior and Lead Variant Scientists. Assists with the day-to-day operations of variant assessment, curation, and documentation to accurately identify and classify genomic alterations detected through genomic testing and translational studies.
Job Description:
Essential Functions:
  • Performs technical review of sequencing (Sanger and Next-Generation) and other molecular data.
  • Provides accurate and timely variant assessment, including evaluation of published literature and clinical data to provide precise, thorough, and thoughtful clinical interpretation of results.
  • Maintains laboratory variant knowledgebase. Assists with curation and harmonization of variant classification changes over time. Maintains knowledge of CAP laboratory requirements related to sequencing and variant analysis. Writes procedures and other documents in support of ongoing laboratory accreditation.
  • Possesses knowledge of current theories and principals of human medical genetics, cancer genetics and hereditary cancer disorders.
  • Thoroughly documents findings, per laboratory standard operating procedures. Assists with research, development, validation, and documentation of new genomic assays. Demonstrates knowledge of and upholds applicable laws and regulations. Maintains knowledge of techniques, procedures, and protocols. Reviews and acknowledges procedures as required.
  • Assists in process development and improvement within the department including participating in quality assurance, continuing education programs, and department meetings.

Education Requirement:
  • Master's Degree in molecular genetics, human genetics, or molecular pathology, required.
  • PhD in biological sciences, preferred.

Licensure Requirement:
(not specified)
Certifications:
(not specified)
Skills:
  • Strong analytical skills and ability to critically read and interpret data from scientific publications.
  • Ability to do technical writing, as well as good communication and computer skills.
  • Good organizational and interpersonal skills.
  • Ability to initiate and work on several projects at a time with minimal supervision; motivation to follow through to completion while adhering to deadlines and maintaining accurate records.

Experience:
  • Two years of significant and relevant experience including variant classification (including Genetic Counselors with relevant experience), required.
  • Two years of experience in genetics, preferred.
  • Extensive experience in data mining and organization.

Physical Requirements:
OCCASIONALLY: Bend/twist, Climb stairs/ladder, Flexing/extending of neck, Fume /Gases /Vapors, Hand use: grasping, gripping, turning, Lifting / Carrying: 11-20 lbs, Lifting / Carrying: 21-40 lbs, Loud Noises, Reaching above shoulder, Repetitive hand/arm use, Squat/kneel
FREQUENTLY: Standing, Walking
CONTINUOUSLY: Audible speech, Color vision, Computer skills, Decision Making, Depth perception, Hearing acuity, Interpreting Data, Lifting / Carrying: 0-10 lbs, Peripheral vision, Problem solving, Seeing - Far/near, Sitting
Additional Physical Requirements performed but not listed above:
The position requires excellent manual dexterity, good visual acuity and hearing, and excellent communication skills as well as a better-than-average ability to write.
"The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individuals so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under their supervision. EOE M/F/Disability/Vet"

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About Nationwide Children's Hospital

Sourced by ZipRecruiter

Nationwide Children's Hospital, established in 1894, is a leading pediatric healthcare system based in Columbus, Ohio, United States. They serve as a primary pediatric network, providing wellness, preventive, diagnostic, treatment, and rehabilitative care for infants, children, adolescents, and adults with congenital disease. Being the third-largest pediatric hospital in the nation, Nationwide Children's Hospital prides itself on its relentless commitment to children and their families, driven by their core values of respect, integrity, determination, empathy, and solidarity. The institution's comprehensive mission is to enhance the health of children by providing high-quality, family-centered care, conducting groundbreaking research, advocating for pediatric health, and training top healthcare professionals.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Columbus, OH, US

Year founded

1892

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