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Senior Software Engineer Jobs in Rochester, MN (NOW HIRING)

Senior AI-ML Engineer

Rochester, MN · On-site +1

$106K - $145K/yr

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

Senior AI-ML Engineer

Rochester, MN · On-site +1

$106K - $145K/yr

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

Senior AI-ML Engineer

Rochester, MN · On-site +1

$106K - $145K/yr

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

Senior AI/ML Engineer (Hybrid)

Rochester, MN

$102K - $140K/yr

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

New

Senior Mechanical Engineer

Rochester, MN · On-site

$102K - $134K/yr

Senior Mechanical Engineer - Bloomington or Rochester, MN (Hybrid) SIGN-ON BONUS up to $10K The ... Perform Load/Energy calculations with software such as Trace 700, IES and similar programs

Senior AI/ML Engineer (Hybrid)

Rochester, MN

$102K - $140K/yr

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

New

Senior AI/ML Engineer (Hybrid)

Rochester, MN · On-site

$106K - $145K/yr

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

New

Join GDIT as a Systems Engineer Senior and build an impactful career in enterprise IT, ... Initialize, configure, and troubleshoot software interfaces * Manage and monitor all installed ...

Sr VDC Engineer

Rochester, MN · On-site

$109K - $142K/yr

Gilbane is seeking a Senior VDC Engineer to lead constructability and coordination tasks on a ... Utilizes 3D design software to identify, communicate, and resolve project challenges * Utilize ...

Sr Electrical Project Engineer

Rochester, MN · On-site

$101.20 - $134.80/hr

Sr Electrical Project Engineer - Rochester, MN Job Location: US-MN-Rochester. Overview We are ... Working knowledge of Revit; familiarity with electrical analysis software such as SKM, Easy Power ...

Senior VDC Engineer

Rochester, MN · On-site

$70 - $100/hr

Utilizes 3D design software to identify, communicate, and resolve project challenges * Utilizes ... Bachelor's degree in Architecture, Engineering, Building Information Modeling (BIM) or related ...

Senior Electrical Project Engineer Location: Rochester, MN Are you looking to join a vibrant ... Familiarity with electrical analysis software (i.e. SKM, Easy Power, Helioscope) and knowledge of ...

Showing results 21-40

Senior Software Engineer information

See Rochester, MN salary details

$76.7K

$145.7K

$195.2K

How much do senior software engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior software engineer in Rochester, MN is $145,655.00, according to ZipRecruiter salary data. Most workers in this role earn between $124,500.00 and $164,200.00 per year, depending on experience, location, and employer.

What is a senior software engineer?

A senior software engineer designs, codes, tests, and maintains computer software. While these are your primary responsibilities as a senior software engineer, you may also have supervisory duties. These include overseeing a team of junior software engineers or developers. The senior software engineer title is sometimes used interchangeably with senior developer, and positions for both may share similar job duties and responsibilities. In general, software engineers are distinguished from developers in that software engineers apply engineering principles to software development.

What are the key skills and qualifications needed to thrive as a senior software engineer, and why are they important?

To thrive as a Senior Software Engineer, you need advanced programming skills, deep understanding of software architecture, and several years of experience in software development, often supported by a relevant degree. Familiarity with tools like Git, CI/CD pipelines, cloud platforms, and expertise in technologies such as Java, Python, or JavaScript are typically required. Leadership, problem-solving, and effective communication are crucial soft skills for mentoring teams and collaborating across departments. These skills ensure the delivery of robust, scalable solutions and drive successful project outcomes in complex technical environments.

What are some common challenges senior software engineers face when mentoring junior team members?

Senior Software Engineers often mentor junior colleagues, which can be incredibly rewarding but also presents challenges. Balancing mentorship with project deadlines can be demanding, as it requires strong time management and communication skills. Additionally, adapting explanations to different learning styles and levels of experience can be tricky. However, effective mentorship helps build a stronger team and can lead to enhanced leadership opportunities for the senior engineer.

What is the difference between Senior Software Engineer vs Software Developer?

AspectSenior Software EngineerSoftware Developer
CredentialsBachelor's or higher in CS or related field; experience often 5+ yearsBachelor's in CS or related field; entry to mid-level experience
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing features, debugging
Industry UsageUsed across tech companies, startups, enterpriseCommon in software firms, startups, freelance work
Search & ComparisonOften compared for experience level, responsibilitiesCompared for entry-level to mid-level roles

The main difference between a Senior Software Engineer and a Software Developer lies in experience, responsibilities, and scope. Senior Software Engineers typically have more experience, lead projects, and mentor others, while Software Developers focus on coding and feature development. Both roles are essential in tech companies, but the Senior Software Engineer position involves higher-level planning and leadership.

What does a senior software engineer do?

A senior software engineer designs, develops, and maintains software applications, often leading projects and mentoring junior team members. They analyze requirements, write code, perform testing, and collaborate with cross-functional teams to ensure quality and efficiency. Proficiency in programming languages, problem-solving skills, and experience with development tools are essential for this role.

What are the most commonly searched types of Software Engineer jobs in Rochester, MN?

The most popular types of Software Engineer jobs in Rochester, MN are:

What are popular job titles related to Senior Software Engineer jobs in Rochester, MN?

For Senior Software Engineer jobs in Rochester, MN, the most frequently searched job titles are:

What job categories do people searching Senior Software Engineer jobs in Rochester, MN look for?

The top searched job categories for Senior Software Engineer jobs in Rochester, MN are:

What cities near Rochester, MN are hiring for Senior Software Engineer jobs?

Cities near Rochester, MN with the most Senior Software Engineer job openings:

Infographic showing various Senior Software Engineer job openings in Rochester, MN as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $145,655 per year, or $70 per hour.

Senior AI-ML Engineer

Mayo Clinic

Rochester, MN • On-site, Remote

$106K - $145K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 9 days ago


Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 699 frontline employees who took The Breakroom Quiz

127th of 888 rated healthcare providers


Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.

Responsibilities

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer sciences. They work closely with a multidisciplinary team, including clinicians, user experience designers, product managers, IT professionals, and external partners, to develop and deploy effective, efficient, and ethical AI/ML solutions into clinical practice to enhance patient care and operational efficiency.
 

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to production. You understand the clinical environment well, including workflows, challenges, and requirements of healthcare providers and patients. You will leverage advanced techniques in AI/ML to analyze vast amounts of healthcare data, including patient records, medical imaging, and genomic information, to develop AI solutions that meet clinical needs and are integrated smoothly into clinical processes. You will develop, integrate, and standardize software components and create, maintain, and follow quality system procedures. You will guide the engineering of systems that are pivotal to developing and deploying these solutions, which encompass everything from design requirements, development, component creation, verification, non-clinical validation, and risk mitigation to ensure our digital health technology products meet and exceed regulatory requirements and setting new benchmarks for safety and effectiveness in clinical settings. Your expertise will also extend to facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines. 
This role is instrumental in providing consultative services to departments and divisions, offering insights into complex business problems. Your ability to communicate complex findings in easily understandable terms to non-technical users will bridge the gap between sophisticated AI technologies and clinical applications.

   Leading component design, development, integration, and standardization to create AI-driven solutions that seamlessly integrate into clinical practice to enhance patient care and clinic operations.
   Collaborating with a multidisciplinary team, including clinicians, user experience designers, product managers, and IT professionals, to understand user needs, workflows, and clinical requirements and assess feasibility. Translating user feedback and requirements into design concepts and usability specifications for AI solutions.
   Leveraging machine learning techniques such as deep learning, natural language processing, computer vision, large language models, etc., to lead the design, development, and deployment of end-to-end AI solutions for healthcare applications.
   Establishing evaluation methodologies and performance metrics to assess AI solutions' effectiveness, usability, and impact in real-world healthcare settings.
   Explaining data analysis results to guide strategic choices and clarify complex insights for non-technical users to connect AI technologies and clinical applications. 
   Overseeing the engineering of systems crucial for developing and deploying AI solutions.
   Facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines.
   Contributing to implementing the best practices and standards for AI development and deployment methodologies, tools, and platforms.
   Providing mentorship, guidance, and technical leadership to junior engineers within the AI enablement team. 
   Providing consultative services on areas of expertise to clinical work units or AI product teams, offering insights and strategies to address complex business problems.
   Providing training and education to healthcare staff on AI tools and technologies.
   Contributing to developing new AI methods and technologies that can advance the state-of-the-art in healthcare AI. 

This position is a combination of remote and on-site work; individual must live within a 100 mile driving distance to the Arizona, Jacksonville or Rochester Mayo Clinic campus.

**Visa sponsorship is not available for this position.  Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.


Qualifications

  A master's degree in engineering, computer science, mathematics, health science, or a related field with 4 years of experience, a bachelor's degree with 6 years of experience. 
  Extensive experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an understanding of healthcare technology.
  Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes.
  Proficiency in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders.
  Demonstrated expertise in cloud infrastructure environment and software development tools.
  Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. 
  Skilled in AI/ML techniques and frameworks.
  Familiarity with best practices in data engineering, data science, AI Engineering, and the MLOps communities.
  Demonstrated initiative in administration, education, software development, and technical reporting. 
  A commitment to mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.


Preferred Qualifications: 
  A Ph.D. or other doctorate is preferred. 
  Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc.
  Knowledge of the healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards.
  Familiarity with systems or quality engineering best practices, regulatory standards, and compliance frameworks, with the ability to adapt these effectively to different project scenarios.
  Demonstrated experience leading technical/quantitative teams in a regulated environment.
  Demonstrated experience creating risk management files and verification/validation strategies for digital health technology products within the healthcare industry.
  Strong expertise in user-centered design, human factors engineering, usability testing methodologies, and evaluation across AI product development. Ability to conduct expert reviews using established usability practices and methods. Presents findings in easy-to-understand terms for the business or clinical practice.


Exemption Status
Exempt
Compensation Detail
$137,134.40 - $205,691.20 / year
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Monday - Friday, 8:00 a.m. - 5:00 p.m. (local time)
International Assignment
No
Site Description
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'.  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter
Pam SivlyQualifications:

  A master's degree in engineering, computer science, mathematics, health science, or a related field with 4 years of experience, a bachelor's degree with 6 years of experience. 
  Extensive experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an understanding of healthcare technology.
  Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes.
  Proficiency in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders.
  Demonstrated expertise in cloud infrastructure environment and software development tools.
  Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. 
  Skilled in AI/ML techniques and frameworks.
  Familiarity with best practices in data engineering, data science, AI Engineering, and the MLOps communities.
  Demonstrated initiative in administration, education, software development, and technical reporting. 
  A commitment to mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.


Preferred Qualifications: 
  A Ph.D. or other doctorate is preferred. 
  Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc.
  Knowledge of the healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards.
  Familiarity with systems or quality engineering best practices, regulatory standards, and compliance frameworks, with the ability to adapt these effectively to different project scenarios.
  Demonstrated experience leading technical/quantitative teams in a regulated environment.
  Demonstrated experience creating risk management files and verification/validation strategies for digital health technology products within the healthcare industry.
  Strong expertise in user-centered design, human factors engineering, usability testing methodologies, and evaluation across AI product development. Ability to conduct expert reviews using established usability practices and methods. Presents findings in easy-to-understand terms for the business or clinical practice.


What Mayo Clinic employees say

Pay

Benefits

Hours and flexibility

Workplace

Get the full story on Breakroom


Mayo Clinic logo

About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919