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Senior Software Engineer Jobs in Rochester, MN (NOW HIRING)

Salas O'Brien

Senior Mechanical Engineer

Rochester, MN · On-site

$102K - $134K/yr

Senior Mechanical Engineer - Bloomington or Rochester, MN (Hybrid) SIGN-ON BONUS up to $10K The ... Perform Load/Energy calculations with software such as Trace 700, IES and similar programs

HGA

Sr Electrical Project Engineer

Rochester, MN · On-site

$101K - $134K/yr

Senior Electrical Project Engineer - Rochester, MN Award-winning Architecture, Engineering ... Familiarity with electrical analysis software (i.e. SKM, Easy Power, Helioscope) and knowledge of ...

HGA

Sr Electrical Project Engineer

Rochester, MN · Hybrid

$101K - $134K/yr

Senior Electrical Project Engineer - Rochester, MN Award-winning Architecture, Engineering ... Familiarity with electrical analysis software (i.e. SKM, Easy Power, Helioscope) and knowledge of ...

Mayo Clinic

Senior IT Analyst/Programmer

Rochester, MN · Hybrid

$102K - $143K/yr

Responsibilities The EHRT Reporting & Analytics team is looking for a Senior Analyst/Programmer to ... Maintains and supports multiple systems or complex software applications and their associated ...

Mayo Clinic

Senior IT Analyst/Programmer

Rochester, MN · Hybrid

$43.50 - $58.75/hr

The EHRT Reporting & Analytics team is looking for a Senior Analyst/Programmer to join our team to ... Maintains and supports multiple systems or complex software applications and their associated ...

Mayo Clinic

Senior IT Analyst/Programmer

Rochester, MN · Hybrid

$45.25 - $61.25/hr

The EHRT Reporting & Analytics team is looking for a Senior Analyst/Programmer to join our team to ... Maintains and supports multiple systems or complex software applications and their associated ...

GDIT

Full Stack Engineer, Mid

Rochester, MN · Hybrid

$140K - $189K/yr

Software Engineering Job Qualifications: Skills: Back-End Development, Data Ingestion, Flask (Web Framework), Python (Programming Language) Certifications: None Experience: 8 + years of related ...

GDIT

Network Engineer Senior

Rochester, MN · On-site

$93K - $108K/yr

Collaborate with network staff to ensure smooth and reliable operation of software and systems for ... Comprehensive knowledge of network engineering principles, methods, and techniques. * Knowledge of ...

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Senior Software Engineer information

See Rochester, MN salary details

$73.7K

$139.9K

$187.4K

How much do senior software engineer jobs pay per year?

As of Jun 19, 2026, the average yearly pay for senior software engineer in Rochester, MN is $139,892.00, according to ZipRecruiter salary data. Most workers in this role earn between $119,600.00 and $157,700.00 per year, depending on experience, location, and employer.

Are senior software engineers still in demand?

Senior software engineers remain in high demand due to ongoing digital transformation across industries. They are sought after for their expertise in programming languages, software development, and system architecture, with opportunities often requiring experience with cloud platforms and modern frameworks.

What is a good salary for a senior software engineer?

A senior software engineer's salary typically ranges from $100,000 to $160,000 annually, depending on experience, location, and industry. In high-cost areas or with specialized skills like cloud computing or machine learning, salaries can exceed this range. Compensation may also include bonuses, stock options, and benefits.

What are Senior Software Engineers?

Senior Software Engineers are experienced professionals who design, develop, and maintain complex software systems. They often lead technical projects, mentor junior team members, and make architectural decisions. Their role involves collaborating with stakeholders to understand requirements, ensuring code quality, and staying up-to-date with the latest technologies. Senior Software Engineers are expected to have strong problem-solving skills and a deep understanding of software development best practices.

What Is a Senior Software Engineer?

A senior software engineer designs, codes, tests, and maintains computer software. While these are your primary responsibilities as a senior software engineer, you may also have supervisory duties. These include overseeing a team of junior software engineers or developers. The senior software engineer title is sometimes used interchangeably with senior developer, and positions for both may share similar job duties and responsibilities. In general, software engineers are distinguished from developers in that software engineers apply engineering principles to software development.

What engineers make $500,000?

Senior software engineers in high-demand industries or at large tech companies can earn $500,000 or more annually, often through a combination of base salary, bonuses, and stock options. Achieving this level typically requires extensive experience, specialized skills in areas like machine learning or cloud computing, and working in competitive markets or leadership roles.

What engineers make $300,000 a year?

Senior Software Engineers with extensive experience, specialized skills in areas like machine learning or cloud computing, and working at large tech companies or in high-cost-of-living regions can earn $300,000 or more annually. Compensation often includes base salary, bonuses, and stock options, especially for those in leadership or highly technical roles.

What are some common challenges Senior Software Engineers face when mentoring junior team members?

Senior Software Engineers often mentor junior colleagues, which can be incredibly rewarding but also presents challenges. Balancing mentorship with project deadlines can be demanding, as it requires strong time management and communication skills. Additionally, adapting explanations to different learning styles and levels of experience can be tricky. However, effective mentorship helps build a stronger team and can lead to enhanced leadership opportunities for the senior engineer.

What is the difference between Senior Software Engineer vs Software Developer?

AspectSenior Software EngineerSoftware Developer
CredentialsBachelor's or higher in CS or related field; experience often 5+ yearsBachelor's in CS or related field; entry to mid-level experience
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing features, debugging
Industry UsageUsed across tech companies, startups, enterpriseCommon in software firms, startups, freelance work
Search & ComparisonOften compared for experience level, responsibilitiesCompared for entry-level to mid-level roles

The main difference between a Senior Software Engineer and a Software Developer lies in experience, responsibilities, and scope. Senior Software Engineers typically have more experience, lead projects, and mentor others, while Software Developers focus on coding and feature development. Both roles are essential in tech companies, but the Senior Software Engineer position involves higher-level planning and leadership.

What are the key skills and qualifications needed to thrive as a Senior Software Engineer, and why are they important?

To thrive as a Senior Software Engineer, you need advanced programming skills, deep understanding of software architecture, and several years of experience in software development, often supported by a relevant degree. Familiarity with tools like Git, CI/CD pipelines, cloud platforms, and expertise in technologies such as Java, Python, or JavaScript are typically required. Leadership, problem-solving, and effective communication are crucial soft skills for mentoring teams and collaborating across departments. These skills ensure the delivery of robust, scalable solutions and drive successful project outcomes in complex technical environments.
More about Senior Software Engineer jobs
What are the most commonly searched types of Software Engineer jobs in Rochester, MN? The most popular types of Software Engineer jobs in Rochester, MN are:
What are popular job titles related to Senior Software Engineer jobs in Rochester, MN? For Senior Software Engineer jobs in Rochester, MN, the most frequently searched job titles are:
What job categories do people searching Senior Software Engineer jobs in Rochester, MN look for? The top searched job categories for Senior Software Engineer jobs in Rochester, MN are:
What cities near Rochester, MN are hiring for Senior Software Engineer jobs? Cities near Rochester, MN with the most Senior Software Engineer job openings:
Senior Software Engineer jobs near you
Senior Principal AI/ML Engineer - Research Sovereign AI

Senior Principal AI/ML Engineer - Research Sovereign AI

Mayo Clinic

Rochester, MN

$115K - $158K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 21 days ago

Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 680 frontline employees who took The Breakroom Quiz

134th of 873 rated healthcare providers

Job description

Position Summary

The Senior Principal AI/ML Engineer  for AI Representation & EMR Vectorization is the senior technical leader and lead scientist responsible for architecting Mayo Clinic's unified multimodal EMR representation layer. This role defines and builds the scientific substrate used by foundational models, clinical agents, and research applications. The individual serves as a hands-on expert and player-coach, guiding technical strategy while contributing directly to model development, graph construction, and representation science. Over time, this position will build and lead a specialized team. 

Key Responsibilities

Scientific & Technical Leadership

  • Design and implement Mayo's multimodal EMR representation AI architecture, including text, imaging, waveform, structured data, temporal sequences, and multi-visit trajectories.
  • Develop graph-based representations and knowledge graphs linking patients, events, attributes, clinical concepts, and embeddings.
  • Integrate graph reasoning, vector similarity search, and hybrid vector-graph pipelines for retrieval-augmented models and agentic reasoning.
  • Define standards for temporal modeling, drift-aware embeddings, and sequence alignment across encounters.

Hands-On Modeling & Engineering

  • Build large-scale embedding pipelines using transformer-based models, contrastive learning, graph neural networks, and hybrid architectures.
  • Implement efficient query layers using vector stores and graph databases.
  • Develop interpretable embedding diagnostics, attribution tools, and graph-based audits to enable safe clinical use.
  • Explore and implement methods for explaining similarity, graph traversals, temporal evolution, and patient-neighborhood reasoning.

Cross-functional Collaboration

  • Work with AI researchers on specialty-specific embeddings, representation refinement, and research prototypes.
  • Collaborate with clinicians to operationalize clinically meaningful features, phenotypes, and longitudinal concepts.
  • Provide scientific input to the Foundational Model Science Program to ensure alignment between representations and model architectures.

Team Leadership

  • Serve as founding technical lead of the Reasoning EMR Representation team.
  • Mentor junior scientists and engineers; build a future team specializing in representation learning and graph-based reasoning.
Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law".  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Required

  • Master's in Computer Science, Machine Learning, Biomedical Engineering, or related field. 9 years of relevant experience, or a bachelor's degree with 11 years of relevant experience. 
  •  Extensive (9+ years) experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an acute understanding of healthcare technology.
  • Hands-on expertise with graph databases, and knowledge graph construction.
  • Strong experience with transformer-based models, contrastive learning, and temporal modeling.

  • Experience designing or deploying vector search systems and hybrid vector-graph reasoning pipelines.

Preferred

  • PhD or Master's in Computer Science, Machine Learning, Biomedical Engineering, or related field.
  • 10+ years experience building production ML systems, including multimodal architectures and representation learning.
  • Experience with EMR data, healthcare multimodality, or clinical data integration.
  • Experience building patient similarity models, temporal embedding systems, or phenotype discovery pipelines.
  • Strong background in explainability, causality, or interpretable ML.
  • Prior experience in a player-coach or team-lead role.

What Mayo Clinic employees say

Pay

Benefits

Hours and flexibility

Workplace

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About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919

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