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Senior Scientist Downstream Process Development Jobs

Kelly Services

Senior Scientist

Lincoln, NE

$79K - $123K/yr

Senior Scientist, Research & Development Location: Lincoln, Nebraska (Onsite) Schedule: Monday ... from R&D into manufacturing environments. * Develop scalable upstream and downstream processes ...

Kelly Services

Senior Scientist

Lincoln, NE · On-site

$79K - $123K/yr

Senior Scientist, Research & Development Location: Lincoln, Nebraska (Onsite) Schedule: Monday ... from R&D into manufacturing environments. * Develop scalable upstream and downstream processes ...

Amgen, Inc.

Process Development Sr Scientist

Thousand Oaks, CA · On-site

$96K - $131K/yr

Process Development Sr Scientist What you will do Let's do this. Let's change the world. In this vital role you will join Amgen's Attribute Sciences (AS) department within the Process Development (PD ...

Amgen

Process Development Sr Scientist

Thousand Oaks, CA · On-site

$96K - $131K/yr

Process Development Sr Scientist What you will do Let's do this. Let's change the world. In this vital role you will join Amgen's Attribute Sciences (AS) department within the Process Development (PD ...

AbbVie

Senior Scientist II Process Development

Worcester, MA

$91K - $124K/yr

... Research Scientist I to join the Purification Development group within Biologics Drug Substance ... The core deliverable of downstream team is to develop robust manufacturing processes and advance ...

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Senior Scientist Downstream Process Development information

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How much do senior scientist downstream process development jobs pay per year?

As of Jun 20, 2026, the average yearly pay for senior scientist downstream process development in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What does a Senior Scientist in Downstream Process Development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a Senior Scientist in Downstream Process Development, and why are they important?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What is the salary of a senior scientist?

The salary of a Senior Scientist Downstream Process Development typically ranges from $90,000 to $150,000 annually, depending on experience, location, and company size. Senior scientists often have advanced degrees and specialized skills in bioprocessing, which can influence compensation levels.

How much does a process development scientist make?

A process development scientist typically earns between $80,000 and $130,000 annually, depending on experience, education, and the specific industry. Salaries in California tend to be higher due to the cost of living and demand for biotech and pharmaceutical expertise.

What is the highest paid type of scientist?

In general, specialized scientists such as pharmaceutical scientists, biotechnologists, and those in executive or leadership roles tend to have the highest salaries. Senior Scientist Downstream Process Development professionals with extensive experience and advanced skills in bioprocessing and GMP environments can also command high compensation, especially in the biotech and pharmaceutical industries.

What are some common challenges faced by Senior Scientists in Downstream Process Development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.

What is a downstream process scientist?

A downstream process scientist specializes in the purification and formulation of biopharmaceutical products after they are produced in bioreactors. They develop and optimize methods such as filtration, chromatography, and centrifugation to ensure product quality and compliance with regulatory standards. This role often requires knowledge of bioprocessing tools, laboratory techniques, and quality control procedures.
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Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $110,545 per year, or $53.1 per hour.
Research Associate, Process Development Downstream

Research Associate, Process Development Downstream

Avid Bioservices

Tustin, CA

$58K - $73K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 14 days ago

Job description

Looking to join a passionate team dedicated to developing and manufacturing life-saving biopharmaceuticals? Avid Bioservices is a leading clinical and commercial biologics CDMO focused on creating innovative solutions to meet the needs of our clients and improve patient outcomes.
Your Role:
The Research Associate, Process Development Downstream will provide laboratory support for Process Development by assisting in the downstream process and/or method development. The Research Associate may be assigned various tasks within the department and outside the department as needed.

Key Responsibilities:
  • Assist in downstream process development and routine purification of antibodies and proteins. Activities include but are not limited to buffer formulation development, buffer preparation, chromatography method development and execution, and filtration process development and operation.
  • Assist in performing in-process and/or routine analytical assays to support downstream development effort. Assays will include protein concentration by A280, and HPLC assays.
  • Execute a process involving chromatography skid, filtration setup, and intermediate testing instruments with minimal supervision.
  • Assist in scale up and process/tech transfer of buffer preparation and downstream process.
  • Compile, analyze data, and write reports, which will be presented in Process Development group meetings or to clients as needed.
  • Experience in High throughput technologies, lab automation and/or process intensification would be advantageous, but not necessary.
  • Evaluate new technologies and/or products under guidance.
  • Perform other duties as assigned.
Minimum Qualifications:
  • B.S. degree in a Biological Science.
  • 1-2 years of relevant industry experience with demonstrated working knowledge of scientific principles.
Position Type/Expected Hours of Work:
This role is a full-time onsite position. Days and hours of work are Monday through Friday, 8:00 a.m. to 5:00 p.m. unless otherwise stated by Supervisor. The employee must also, if instructed, have the ability to work overtime and/or weekends when necessary.
Compensation:
We offer competitive compensation packages for this role, including a base salary, performance-based bonuses, and comprehensive benefits such as health, dental, and vision insurance, 401(k) matching, and paid time off.
The compensation range for this role is $58,400 - $73,000 annually depending on experience and qualifications. Additionally, we offer opportunities for career growth and development as well as a supportive and inclusive work environment.
We understand the importance of attracting and retaining top talent. The expected base pay range for this position is ($58,400 - $73,000) plus bonus and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. Our benefits include health, dental and vision insurance benefits to ensure your well-being.
Who you are:
  • You have a "bring it on!" team player approach and an unshakable positive attitude, always ready to tackle anything that comes your way.
  • Your written and verbal skills are out of this world, and you communicate with clarity and confidence.
  • You have exceptional multitasking skills and an unparalleled attention to detail that ensure the smooth running of everything.
  • You are a master at building relationships, capable of establishing connections with anyone, be it team members, clients, vendors, or suppliers.
Physical Demands & Work Environment:
In this dynamic role, expect a blend of regular activities like sitting, standing, and walking, with occasional physically engaging tasks such as lifting objects up to 20 pounds. The work environment might expose you to electrical shocks, toxic chemicals, vibrations, or loud noise levels occasionally. However, reasonable accommodations are available to enable individuals with different abilities to perform effectively, ensuring a supportive and adaptable work setting. Your visual acuity, including close, distance, and color vision, will be essential in navigating through the diverse day-to-day demands of this position.
Employment Type: Full-Time

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