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Senior Scientist Downstream Process Development Jobs

MSD Malaysia

$87 - $137/hr

Scientist - Downstream **Vaccines and Advanced Biotechnologies Process R&D** Our Company in Rahway, N.J., U.S.A. known as Our Company in the United States and Canada, is a global health care leader ...

New

Legend Biotech USA, Inc.

The successful candidate will drive scientific excellence in downstream processing (DSP)-including ... In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical ...

Merck & Co.

Scientist - Downstream Vaccines and Advanced Biotechnologies Process R&D - - Our Company in Rahway, N.J., U.S.A. known as Our Company in the United States and Canada, is a global health care leader ...

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How much do senior scientist downstream process development jobs pay per year?

As of Aug 21, 2026, the average yearly pay for senior scientist downstream process development in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What does a senior scientist in downstream process development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a senior scientist in downstream process development?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by senior scientists in downstream process development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.
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Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 14% Part Time, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $110,545 per year, or $53.1 per hour.

Senior Scientist, Process Development (AAV)

Lexeo Therapeutics

New York, NY • On-site

$136K - $172K/yr

Full-time

Re-posted 13 days ago

Job description

Role Summary
The Senior Scientist supports development, optimization, and scale-up of AAV manufacturing processes using Sf9/baculovirus and HEK-based systems. This role contributes to early and late-stage CMC activities including process characterization, technology transfer, control strategy development, and regulatory documentation. The level of responsibility, technical leadership, and cross-functional ownership will be commensurate with experience.
Primary Responsibilities
  • Design, execute, and lead process development and optimization studies for AAV manufacturing using Sf9 cells/baculovirus and HEK platforms.
  • Perform hands-on laboratory work to execute process development and optimization experiments, generate critical process data, and support technical troubleshooting.
  • Support and, as appropriate, define study designs to drive process optimization, scalability, robustness, and technology transfer for clinical and late-stage programs.
  • Collaborate with and provide technical leadership across upstream, downstream, analytical, manufacturing, and quality teams to evaluate process performance and product quality.
  • Support or own late-stage CMC deliverables, including process characterization, risk assessments, control strategy development, technology transfer, and validation readiness.
  • Author, review, and provide technical input for study protocols, technical reports, and regulatory documentation.
  • Support or lead troubleshooting, investigations, mentoring of junior staff, and continuous process improvement initiatives.

Required Skills and Qualifications
  • Master's degree in biochemical engineering, bioprocess engineering, molecular biology, cell biology, or relevant life sciences or engineering discipline with a minimum of 6 years of relevant experience, or PhD with at least 3 years of relevant experience.
  • Hands-on experience with upstream AAV production using Sf9 cells/baculovirus and HEK platforms required.
  • Understanding of virus/viral vector properties and experience with development of upstream and downstream processes for viral vectors or gene therapy products are highly desirable.
  • Working knowledge of downstream processing and analytical testing preferred.
  • Experience supporting process optimization, characterization, and late-stage CMC activities preferred.
  • Demonstrated leadership in process development, cross-functional collaboration, and late-stage CMC readiness is expected.
  • Experience authoring and reviewing regulatory documentation preferred.

$136,200 - $172,000 a year
Compensation is dependent on qualifications and experience
About LEXEO
Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich's Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.
Our work culture is a hybrid model with 2 days in the New York City office and 3 days working from home.
LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

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