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Downstream Process Development Scientist - Tech Transfer Consultant

San Carlos, CA · On-site

$75 - $90/hr

Downstream Process Development Scientist / Tech Transfer Consultant * Employment Type: Contract * Compensation: $75-$90/hour, depending on experience and technical background. * Function: Process ...

CEDENT

Senior Scientist, Process Development

Watertown, MA · On-site

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

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How much do senior scientist downstream process development jobs pay per year?

As of Aug 21, 2026, the average yearly pay for senior scientist downstream process development in the United States is $110,545.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,500.00 and $125,000.00 per year, depending on experience, location, and employer.

What does a senior scientist in downstream process development do?

A Senior Scientist in Downstream Process Development focuses on developing, optimizing, and scaling up processes to purify biological products such as proteins or antibodies after cell culture (the 'downstream' part of biomanufacturing). They design experiments, analyze data, and work with cross-functional teams to ensure product quality and regulatory compliance. Their role is critical in moving biopharmaceutical products from research to commercial production by ensuring efficient and robust purification processes.

What are the key skills and qualifications needed to thrive as a senior scientist in downstream process development?

To thrive as a Senior Scientist in Downstream Process Development, you need advanced knowledge in bioprocess engineering, protein purification, and process scale-up, typically supported by a Ph.D. or Master’s degree in a relevant field. Expertise with chromatography systems (such as AKTA), analytical instrumentation, and familiarity with regulatory requirements like GMP are essential. Strong problem-solving abilities, leadership, and effective communication skills distinguish top performers in this role. These competencies are crucial for developing robust, scalable processes that meet quality standards and drive successful product development.

What are some common challenges faced by senior scientists in downstream process development, and how can they be addressed?

Senior Scientists in Downstream Process Development often encounter challenges such as optimizing purification processes for novel biologics, scaling up from lab to production scale, and ensuring product consistency and regulatory compliance. Addressing these challenges typically involves close collaboration with cross-functional teams, continuous process optimization, and staying current with industry advancements in chromatography and filtration technologies. Proactive problem-solving, effective communication, and leveraging data analytics are also key strategies for overcoming obstacles in this role.
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Senior Scientist Downstream Process Development jobs near you
Infographic showing various Senior Scientist Downstream Process Development job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 14% Part Time, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $110,545 per year, or $53.1 per hour.

KBI: US - Downstream Process Development Scientist II

KBI Biopharma, Inc.

Boulder, CO • On-site

$106.48 - $146.41/hr

Other

Re-posted 16 days ago

KBI Biopharma rating

6.5

Company rating: 6.5 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

Job description

Job Summary

The Downstream Process Development (PD) Scientist II provides process development ownership for a product, including all development and design decisions, with some oversight and supervision from senior process development staff. They apply advanced scientific principles to design and execute laboratory studies for unit operation development and optimization, and solve problems of increasing scope and complexity. They possess a strong working knowledge of the downstream functional area with strong aptitude in chromatography and tangential flow filtration, and a developing understanding of phase-appropriate practices and expectations. They author and review technical documents including protocols and reports commensurate with PD compliance and quality standards. This workflow encompasses process development scope as well as support of technology transfer activities in preparation for cGMP production. The PD Scientist II is responsible for maintaining training compliance, according to site expectations. This is a salaried exempt position, with the expectation to cover shift work as needed to support laboratory activities and organizational need.

Responsibilities
  • Execute process development, process characterization, and technology transfer of microbial processes to commercial cGMP facility.
  • Work toward developing a broad knowledge of state‑of‑the‑art principles and theory.
  • Produce high quality documentation and client reports suitable for publication and regulatory requirements.
  • Compile and present data to clients.
  • Support downstream process development efforts in the laboratory and manufacturing areas.
  • Execute experiments with some oversight.
  • Conceptualize and propose process development and manufacturing based on process data.
  • Execute downstream unit operations such as chromatography, tangential flow filtration, normal filtration, as well as sampling and basic analysis of process samples; concentration, pH, and conductivity.
  • Lead the downstream portion of development, process characterization, and/or technology transfer programs, acting as subject matter expert (SME), and directing the efforts of the team in meeting the project deliverables.
  • Provide technical support for cGMP manufacturing through floor coverage, batch document review, and support of deviations and change controls with some oversight.
  • Develop and maintain a current understanding of cGMP and other regulatory requirements.
  • Adhere to all safety requirements and assure that departmental employees comply with required safety procedures.
  • Conceptualize, propose and execute the evaluation, development and implementation of new downstream technologies leading to process improvements and efficiency of operation in support of downstream process development and manufacturing activities.
  • Document procedures, observations, and results in laboratory notebooks and maintain training compliance, according to site expectations.
  • Review documentation and records as assigned.
Requirements
  • B.S. degree and a minimum of 6+ years of related experience; M.S. and 4+ years of related experience or Ph.D. and 1+ year of related experience in a scientific discipline.
  • Experience with downstream process development and chromatography equipment.
  • Excellent written and verbal communication skills, focus on customer service, and ability to meet strict client deadlines.
  • Highly collaborative.
  • Flexibility of hours to support downstream processes.
  • Knowledge of GMPs and biotechnology‑derived product regulations preferred.
Salary

Salary: $106,480-$146,410

EEO Statement

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its workforce. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

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