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Senior Python Software Engineer Jobs in Colorado

GliaCell Technologies

Senior Software Engineer

Aurora, CO · On-site

$124K - $163K/yr

They are seeking a Senior Software Engineer to provide technical expertise in sustaining critical ... Python development • AWS ML certificate or Knowledge implementing production scale AI/ML ...

Huck Adventures

Senior Software Engineer

Boulder, CO · On-site

$137K - $180K/yr

We are seeking a Senior Software Engineer to become an integral part of our team! You will be ... Knowledge of Java, Python, or other programming languages * Familiarity with relational databases ...

Huck Adventures

Senior Software Engineer

Boulder, CO · On-site

$137K - $180K/yr

We are seeking a Senior Software Engineer to become an integral part of our team! You will be ... Knowledge of Java, Python, or other programming languages * Familiarity with relational databases ...

asrcfh

Senior Software Engineer

Aurora, CO · Hybrid

$124K - $164K/yr

We are seeking a Senior Software Engineer to design, develop, and evolve advanced core software ... Familiarity or direct project exposure integrating AI/ML frameworks (e.g., Python-based modeling ...

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Showing results 21-40

All JobsPython Software Engineer JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in Colorado

Senior Python Software Engineer information

See Colorado salary details

$57.8K

$149.3K

$205K

How much do senior python software engineer jobs pay per year?

As of Aug 6, 2026, the average yearly pay for senior python software engineer in Colorado is $149,290.00, according to ZipRecruiter salary data. Most workers in this role earn between $127,800.00 and $171,900.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.
What are popular job titles related to Senior Python Software Engineer jobs in Colorado? For Senior Python Software Engineer jobs in Colorado, the most frequently searched job titles are:
What job categories do people searching Senior Python Software Engineer jobs in Colorado look for? The top searched job categories for Senior Python Software Engineer jobs in Colorado are:
Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in Colorado as of July 2026, with employment types broken down into 94% Full Time, 3% Part Time, and 3% Contract. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $149,290 per year, or $71.8 per hour.

Senior Software Engineer

GliaCell Technologies

Aurora, CO • On-site

$124K - $163K/yr

Full-time

Re-posted 20 days ago

Job description

Job Summary:
GliaCell Technologies is focused on Software & System Engineering in Enterprise and Cyber Security solution spaces. They are seeking a Senior Software Engineer to provide technical expertise in sustaining critical mission-related software and systems for a U.S. Government customer.
Responsibilities:
• The Software Engineer develops, maintains, and enhances complex and diverse software systems (e.g., processing-intensive analytics, novel algorithm development, manipulation of extremely large data sets, real-time systems, and business management information systems) based upon documented requirements.
• Works individually or as part of a team.
• Reviews and tests software components for adherence to the design requirements and documents test results.
• Resolves software problem reports.
• Utilizes software development and software design methodologies appropriate to the development environment.
• Provides specific input to the software components of system design to include hardware/software trade-offs, software reuse, use of Commercial Off-the-shelf (COTS)/Government Off-the-shelf (GOTS) in place of new development, and requirements analysis and synthesis from system level to individual software components.
Qualifications:
Required:
• An active or rein-statable TS/SCI with Polygraph security clearance
• U.S. Citizenship
• 14+ years experience as a Software Engineer and a Bachelor’s degree in Computer Science or related
• Works well independently as well as on a team
• Strong communication skills
• Python development
• AWS ML certificate or Knowledge implementing production scale AI/ML solutions/systems
• AWS Kubernetes (docker containerization) understanding or Solution Architect Certification
• Knowledge of AI tools and developing deep learning models
• Experience w/cloud infrastructure management
Preferred:
• AI tools (ChatGPT, Google GEMINI and GROK)
• AI Tools and Language Models are Agentic and Generative AI concepts
Company:
GliaCell Technologies focuses on software engineering in the cloud and cybersecurity domains. Founded in 2014, the company is headquartered in Columbia, USA, with a team of 11-50 employees. The company is currently Early Stage.

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