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Senior Python Software Engineer Jobs (NOW HIRING)

Sr Staff / Senior Python Software Engineer

Boulder, CO · On-site

$126K - $169.60K/yr

SciTec is seeking a Sr Staff / Senior Python Software Engineer to design, develop, and sustain highquality software systems that power advanced analysis and realtime data processing workflows. This ...

Senior Python Software Engineer

$124.40K - $167.40K/yr

Worldpay is a leading name in payments, looking for a Senior Python Engineer to join their Pazien ... Responsibilities : • Designing, programming, debugging and modifying software enhancements. • ...

Senior Python Software Engineer

Boston, MA · On-site

$119K - $179.75K/yr

What you'll own as the Senior Python Engineer * Designing, programming, debugging and modifying software enhancements. * Interacting with product managers and users to define requirements and ...

Sr. Python Developer

Richardson, TX · Hybrid

$110.30K - $148.50K/yr

Sr. Python Developer Location : Richardson, TX -Work from office 3 days a Week Full Time / Contract ... Software Engineering or a related field. • In depth understanding of the Python software ...

Senior Python Software Engineer

Boston, MA · On-site

$119K - $179.75K/yr

... Python Engineer * Designing, programming,debuggingandmodifyingsoftware enhancements. * Interactingwith product managers and users to define requirements and modifications. * Participating in software ...

Senior Python Software Engineer

Miami, FL · On-site

$125K - $350K/yr

Software Engineers work closely with business leaders to develop and deliver custom software ... Python • The ambition to solve open-ended problems using analytical methods • Knowledge of ...

Python Software Engineer, Chicago, IL A proprietary trading firm with three locations in Chicago, London, & New York, seeks a Python Software Engineer to join its Data Infrastructure team, to help ...

We have partnered with our client in their search for a Python Software Engineer in Houston, TX.. Responsibilities * Hands-on practical experience in system design, application development, testing ...

Python Software Engineer Location: Columbus, OH Job Type: Contract/ W2 Highly experienced Python software engineer who is looking for a challenging role where he/she can learn lots more and work on ...

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Senior Python Software Engineer information

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$55K

$142K

$195K

How much do senior python software engineer jobs pay per year?

As of May 28, 2026, the average yearly pay for senior python software engineer in the United States is $141,976.00, according to ZipRecruiter salary data. Most workers in this role earn between $121,500.00 and $163,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Python Software Engineer, and why are they important?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by Senior Python Software Engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What does a Senior Python Software Engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

More about Senior Python Software Engineer jobs
What cities are hiring for Senior Python Software Engineer jobs? Cities with the most Senior Python Software Engineer job openings:
What states have the most Senior Python Software Engineer jobs? States with the most job openings for Senior Python Software Engineer jobs include:
Infographic showing various Senior Python Software Engineer job openings in the United States as of May 2026, with employment types broken down into 79% Full Time, 18% Part Time, 1% Temporary, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $141,976 per year, or $68.3 per hour.
Senior Python Software Engineer

Senior Python Software Engineer

GliaCell Technologies

Linthicum Heights, MD • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 19 days ago


Job description

***An active or rein-statable TS/SCI with Polygraph security clearance is REQUIRED. Please do not apply if you currently do not possess this level of clearance.***
Are you a Senior Python Software Engineer who is ready for a new challenge that will launch your career to the next level?

  • Tired of being treated like a company drone?
  • Tired of promised adventures during the hiring phase, then dropped off on a remote contract and never seen or heard from the mothership again?
  • Our engineers were certainly tired of the same.  

At GliaCell our slogan is “We make It happen”.

  • We will immerse you in the latest technologies.
  • We will develop and support your own personalized training program to continue your individual growth. 
  • We will provide you with work that matters with our mission focused customers, and surround you with a family of brilliant engineers. 

Culture isn’t something you need to talk about…if it just exists. 

If this sounds interesting to you, then we’d like to have a discussion regarding your next adventure! If you want to be a drone, this isn’t the place for you.

We Make It Happen!

GliaCell Technologies focuses on Software & System Engineering in Enterprise and Cyber Security solution spaces. We excel at delivering stable and reliable software solutions using Agile Software Development principles. These provide us the capability to deliver a quick turn-around using interactive applications and the integration of industry standard software stacks.

GliaCell’s Enterprise capabilities include Full-Stack Application Development, Big Data, Cloud Technologies, Analytics, Machine Learning, AI, and DevOps Containerization. We also provide customer solutions in the areas of CND, CNE, and CNO by providing our customers with assessments and solutions in Threat Mitigation, Vulnerability Exposure, Penetration Testing, Threat Hunting, and Preventing Advanced Persistent Threat.

We Offer:

  • Long term job security
  • Competitive salaries & bonus opportunities
  • Challenging work you are passionate about
  • Ability to work with some amazingly talented people

Job Description:

GliaCell is seeking a Senior Python Software Engineer on one of our subcontracts. This is a full-time position offering the opportunity to support a U.S. Government customer. The mission is to provide technical expertise that assists in sustaining critical mission-related software and systems to a large government contract.

Key Requirements:

To be considered for this position you must have the following:

  • Possess an active or rein-statable TS/SCI with Polygraph security clearance.
  • U.S. Citizenship.
  • 6+ years Software Engineering experience and a MS degree in Computer Science or related, or 8+ years of experience and a BS Degree, or 10+ years of experience and an AA Degree, or +12 years of experience and a High School Diploma
  • Works well independently as well as on a team. 
  • Strong communication skills. 

Description:

  • As part of the Secure the Enterprise initiative, develop capabilities to shift from the current manual system security evaluation and authorization process to a new model that emphasizes automation, streamlined processes and approvals, continuous monitoring and assessment, and network data gathering across the entire life cycle of a project.

Responsibilities:

  • You will provide the development, test, deploy, and sustainment of various Python based REST end points, microservices, and data model management capabilities utilizing Django and Flask frameworks to interact with data models stored in MariaDB or MongoDB and send data upon request, in JSON format, to UI front ends.
  • The developer will provide middleware and backend support to all system applications.

Key Skills:

  • Python
  • Docker
  • Experienced using Django or Flask
  • Databased experience using MongoDB or MariaDB
  • ReST endpoint development
  • Micro service model

Desired Skills:

  • AWS or other cloud experience
  • JSON and/or XML serialization
  • Jira
  • Confluence
  • Git version control
  • Agile

Location: Linthicum Heights, MD

Salary Range: The salary range for this full-time position is $170,000 to $260,000. Our salary ranges are determined by position, level, skills, professional experience, relevant education and certifications. The range displayed on each job posting reflects the minimum and maximum target salaries for this position across our projects. Within the range, your salary is determined by your individual benefits package selection. Your recruiter can share more about the specific salary range for your preferred position during the hiring process. SIGN-ON BONUS ELIGIBLE.

Benefits:

  • CareFirst Medical Coverage for Employee and Dependents 
  • Guardian Dental and Vision Coverage for Employee and Dependents 
  • Up to 25 Days of Paid Time Off
  • Up to 40 hours of PTO Carryover
  • 11 Federal Government Holidays
  • Work From Home Opportunities
  • 401K Company Contribution, Fully Vested Day 1
  • Discretionary, Certification, and Sign-On Bonus Potential 
  • Employee Referral Bonus Program 
  • Annual Professional Development 
  • 100% Premium Covered for Life & Disability Insurances
  • Additional Voluntary Life Insurance Coverage Available 
  • Employee Assistance Program
  • Travel Protection Program
  • Financial Planning Assistance 
  • Bereavement and Jury Duty Leave
  • Monthly Team and Family Events
  • Technology Budget
  • Global Entry
  • Annual Swag Budget

Learn more about GliaCell Technologies: https://gliacelltechnologies.applytojob.com/apply/

To apply for this position, respond to this job posting and attach an updated resume for us to review. 

GliaCell Technologies, LLC is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.

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