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Senior Python Software Engineer Jobs in San Diego, CA

Foresite Labs

Senior Software Engineer

San Diego, CA · On-site

$130K - $171K/yr

We are looking for a Senior Software Engineer who is equally comfortable writing low-level C/C++ for embedded targets and building higher-level Python applications that tie a system together. You ...

Cypress HCM

Senior Software Engineer

San Diego, CA

$130K - $171K/yr

Senior Software Engineer Responsibilities: * Provide technical expertise within the Engineering ... Able to Develop and Maintain Python based desktop GUI applications to control and monitor Automated ...

Qualcomm

#Senior Software Engineer

San Diego, CA · On-site

$130K - $171K/yr

As a Senior Software Engineer, you will design, develop, and optimize software solutions for ... Python, etc. Preferred : • Master's degree in Computer Science, Engineering, or a related field ...

STR

Senior Software Engineer

San Diego, CA · On-site

$130K - $171K/yr

They are seeking a Senior Software Engineer to transform advanced concepts and algorithms into ... or Python • BS with 5+ years experience or MS with 3+ years experience in Computer Science ...

Singular Genomics

Sr. Software Engineer

San Diego, CA · On-site

$129K - $171K/yr

Position Summary: We're looking for a Senior Software Engineer to join our core software team and ... You don't need deep expertise in any one niche, you need solid Python fundamentals, a get-things ...

STR

Senior Software Engineer

San Diego, CA · On-site

$130K - $171K/yr

They are seeking a Senior Software Engineer to join their Systems Autonomy, Analysis, and Modeling ... or Python • BS with 5+ years experience or MS with 3+ years experience in Computer Science ...

TIAG

Senior Software Engineer

San Diego, CA

$129K - $170K/yr

TIAG is now hiring a Senior Software Engineer to join our team full time in San Diego, CA. In this ... Design, build, and maintain efficient, reusable, and reliable Python code using the Django ...

Leidos

Software Engineer

La Jolla, CA · On-site

$87K - $157K/yr

Description Leidos Defense is seeking a Senior Software Engineer to develop and support the ... Create and maintain Python-based utilities and scripts to support system administration, testing ...

Leidos

Software Engineer

National City, CA · On-site

$87K - $157K/yr

Description Leidos Defense is seeking a Senior Software Engineer to develop and support the ... Create and maintain Python-based utilities and scripts to support system administration, testing ...

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All JobsPython Software Engineer JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in San Diego, CA

Senior Python Software Engineer information

See San Diego, CA salary details

$58.4K

$150.7K

$207K

How much do senior python software engineer jobs pay per year?

As of Jul 27, 2026, the average yearly pay for senior python software engineer in San Diego, CA is $150,737.00, according to ZipRecruiter salary data. Most workers in this role earn between $129,000.00 and $173,600.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are some common challenges faced by Senior Python Software Engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What are the key skills and qualifications needed to thrive as a Senior Python Software Engineer, and why are they important?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What does a Senior Python Software Engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.
What are popular job titles related to Senior Python Software Engineer jobs in San Diego, CA? For Senior Python Software Engineer jobs in San Diego, CA, the most frequently searched job titles are:
What job categories do people searching Senior Python Software Engineer jobs in San Diego, CA look for? The top searched job categories for Senior Python Software Engineer jobs in San Diego, CA are:
What cities near San Diego, CA are hiring for Senior Python Software Engineer jobs? Cities near San Diego, CA with the most Senior Python Software Engineer job openings:
Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in San Diego, CA as of July 2026, with employment types broken down into 90% Full Time, 6% Part Time, 1% Temporary, and 3% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $150,737 per year, or $72.5 per hour.

Django/Python Software Developer

Drive Current

San Diego, CA

$53.25 - $73.50/hr

Other

Medical, Dental, Vision, Retirement, PTO

Posted yesterday

Job description

Company Description

We're an agile company of 20 software development professionals / geeks. We embrace iterative development, test automation and frequent releases. We strive to continuously learn and evolve while delivering working software that we can all be proud of.   

Job Description

We are working on a large software platform to help "traditional media companies" (radio, tv, cable) and their auto dealer customers better track and improve advertising spends and campaigns.  You will be working with industry experts in a start-up atmosphere, but with a sustainable pace (good work/life balance) and stable funding.

The application is being built with Python, Django, HTML5, Angular and PostgreSQL. We're looking for someone with at least three years of Python experience. You'll be proving yourself on the fly, so if you're a truly great candidate, but with less experience, please apply anyway.  You'll be working along side Oz, Duane, Adam, Jared and David.  View their bio's at http://www.drivecurrent.com. 

Qualifications
  • Candidate must possess intermediate to expert knowledge and experience working with Python / Django
  • Proficient with SQL and database design, particularly PostgreSQL.
  • Ability to read and handcode HTML.
  • AJAX and Javascript proficiency a plus.
  • Comfortable with basic Linux/Unix command line environment.
  • Must know OOP, Design Patterns and MVC design methodologies.

Bachelors degree in Computer Science, Computer Engineering, Information Systems or equivalent experience is preferred.  There are plenty of self-taught people on the team as well though.

Additional Information

Benefits include:

  • 4 weeks personal time off / vacation per year
  • 9 paid federal holidays
  • Health, vision and dental insurance
  • 401K with 4% matching
  • Free lunches, healthy snacks, beverages, etc.
  • Paid mobile phone, home internet and gym membership
  • Education reimbursement for relevant classes

We have a fun, informal working environment and strongly believe in maintaining a good work / life balance. You'll work with a team of passionate developers that use the most modern and progressive software development practices.


Learn more about our team at www.drivecurrent.com


Keywords: Python, Django, PostgreSQL, Javascript, HTML5, jQuery, LAMP, Linux, Nginx, Web, Internet, Website, Development, Software Engineer, Sofware, Programming, Developer.

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