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Senior Protein Engineer Jobs (NOW HIRING)

Cedent

Senior Scientist (Branford, CT)

Branford, CT · On-site

$90K - $123K/yr

We're hiring a Senior or Principal Scientist to join our Biotherapeutics team's collaborative group ... If you're a protein engineer who thrives in the lab and wants your work to move swiftly toward ...

Merck & Co.

... Senior Director to contribute to our Company's protein therapeutic efforts from discovery through ... engineering, molecular biology, bioengineering, or related STEM field; Relevant experience that ...

Manifold Bio

Senior Director, Biotherapeutics

Boston, MA

$240K - $340K/yr

Our team of protein engineers, biologists, and computational scientists works across this full ... Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature ...

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Senior Protein Engineer information

See salary details

$59.5K

$126.6K

$183.5K

How much do senior protein engineer jobs pay per year?

As of Aug 12, 2026, the average yearly pay for senior protein engineer in the United States is $126,557.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,500.00 and $143,500.00 per year, depending on experience, location, and employer.

What is the difference between Senior Protein Engineer vs Protein Scientist?

AspectSenior Protein EngineerProtein Scientist
Required CredentialsBachelor's or Master's in Biochemistry, Molecular Biology, or related fields; experience in protein engineeringBachelor's or Master's; often a Ph.D. for advanced research roles; expertise in protein analysis
Work EnvironmentBiotech or pharmaceutical R&D labs, manufacturing facilitiesAcademic labs, research institutions, biotech companies
Employer & Industry UsageUsed in biotech, pharma, and industrial enzyme companiesCommon in academic research, biotech R&D, and pharmaceutical development

While both roles focus on proteins, Senior Protein Engineers typically work on designing and optimizing proteins for industrial applications, whereas Protein Scientists often conduct fundamental research to understand protein functions. The roles overlap in skills and industry but differ in focus and seniority.

What is a senior protein engineer?

Senior Protein Engineers are experienced scientists who design, modify, and optimize proteins for specific industrial, medical, or research applications. They use advanced techniques in molecular biology, biochemistry, and computational modeling to improve protein stability, activity, or specificity. These professionals often lead research projects, mentor junior staff, and collaborate with interdisciplinary teams to bring innovative protein-based solutions to market.

What skills and qualifications are needed to be a senior protein engineer?

To thrive as a Senior Protein Engineer, you need expertise in protein biochemistry, molecular biology, and structural biology, typically supported by a Ph.D. or equivalent experience in a related field. Proficiency in tools such as protein modeling software (e.g., Rosetta, PyMOL), high-throughput screening platforms, and familiarity with analytical instruments like mass spectrometers is essential. Strong problem-solving, collaboration, and project management skills help drive innovation and successful cross-functional teamwork. These skills and qualities are crucial for efficiently designing, optimizing, and characterizing proteins to advance scientific discoveries and product development.

How much does a senior protein engineer make?

A senior protein engineer typically earns between $90,000 and $150,000 annually, depending on experience, location, and industry. They often work in biotech or pharmaceutical companies, utilizing skills in molecular biology, protein design, and laboratory techniques.

How does a senior protein engineer collaborate with cross-functional teams during the development of new protein therapeutics?

Senior Protein Engineers often work closely with multidisciplinary teams, including molecular biologists, biochemists, computational scientists, and regulatory specialists, to bring new protein therapeutics from concept to reality. They contribute their expertise in protein design and engineering, lead experimental planning, and interpret complex data to guide project direction. Regular meetings and collaborative problem-solving sessions are common, ensuring that project goals align across departments. This collaborative environment fosters innovation, but also requires strong communication and project management skills.
More about Senior Protein Engineer jobs
What cities are hiring for Senior Protein Engineer jobs? Cities with the most Senior Protein Engineer job openings:
What are the most commonly searched types of Protein Engineer jobs? The most popular types of Protein Engineer jobs are:
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What job categories do people searching Senior Protein Engineer jobs look for? The top searched job categories for Senior Protein Engineer jobs are:
Senior Protein Engineer jobs near you
Infographic showing various Senior Protein Engineer job openings in the United States as of August 2026, with employment types broken down into 92% Full Time, 2% Part Time, and 6% Contract. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution, with an average salary of $126,557 per year, or $60.8 per hour.

Senior Scientist (Branford, CT)

Cedent

Branford, CT • On-site

$90K - $123K/yr

Full-time

Re-posted 25 days ago

Job description

We're hiring a Senior or Principal Scientist to join our Biotherapeutics team's collaborative group focused on designing and advancing first-in-class immune-engaging biologics. If you're a protein engineer who thrives in the lab and wants your work to move swiftly toward patients, this role offers real opportunity, purpose, and scientific challenge.
What You'll Work On
  • Design and optimize novel antibody and bispecific formats that power our next-generation immunotherapies
  • Lead antibody engineering from idea to construct to bench - including expression, purification, and characterization
  • Improve key attributes like affinity, stability, specificity, and PK using modern tools and data
  • Drive developability assessments with platforms like SPR, BLI, DSC, DLS, ciEF, and LC-MS
  • Collaborate across functional teams to support candidate selection and preclinical development
  • Develop and refine functional assays for biologic characterization
  • Present findings in a clear, compelling way to multidisciplinary teams
  • Mentor junior scientists (if interested) and help shape our growing discovery organization
What You Bring
  • PhD in Biochemistry or a related field and 5+ years of industry experience (or)
  • MS with 10+ years in antibody engineering roles
  • Strong foundation in antibody structure-function relationships and biologics drug development
  • Expertise in protein design, expression, purification, and biophysical characterization
  • Deep experience with bispecific or multispecific formats and familiarity with T cell engagers
  • Working knowledge of structure-activity relationships and/or molecular modeling is a plus
  • Experience with mammalian expression systems (e.g., CHO/HEK), cell-based assays, or phage/yeast display is valuable
  • Strong communication, data interpretation, and cross-functional collaboration skills
Why You'll Love Working Here
  • Direct impact: Your ideas and experiments will influence platform design and help shape clinical programs
  • Cutting-edge science: Work on a truly novel immunotherapy approach in a scientifically rigorous, fast-moving environment
  • Personal growth: Take on visible, high-impact projects in a startup culture where contributions are recognized and development is supported
  • Collaborative culture: Join a tight-knit, mission-driven team that values open communication, learning, and teamwork
  • Mission with meaning: Be part of a company working to give more patients real hope in the fight against cancer
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About Cedent

Sourced by ZipRecruiter

CEDENT strives to attract and retain the best people and provide an environment where they can all develop professionally and build a rewarding career. As a result, we create an inclusive environment that is rich in diversity, acknowledges each individual's uniqueness and promotes respect, personal achievement and stewardship. Our clients are global and so is CEDENT. We build and maintain a global workforce that includes people from different backgrounds, with a vast range of skills and experience all united by a common culture and commitment to help our clients achieve high performance. Cultivating a diverse workforce and inclusive work environment makes business sense. Our peoples varied skills are the talent engine that powers CEDENT, enabling it in turn to deliver the innovative solutions that help our clients outperform competitors.

Industry

It services

Company size

11 - 50 Employees

Headquarters location

Plano, TX, US

Year founded

2008

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