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Senior Clinical Trial Manager Jobs (NOW HIRING)

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Senior Clinical Trial Manager

Blue Bell, PA · On-site +1

Senior Clinical Trial Manager, Biotech - Remote, US ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients ...

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Senior Clinical Trial Manager

Blue Bell, PA · Remote

Senior Clinical Trial Manager (Oncology) - Remote, US ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients ...

Vor Bio

Senior/Clinical Trial Manager (CTM)

Boston, MA

$175K - $195K/yr

Vor Biopharma is seeking a Clinical Trial Manager/Sr. Clinical Trial Manager who will be responsible for leading all aspects of clinical trial management from study start through study closure. Key ...

Shifamed

Sr. Clinical Trial Manager

Los Gatos, CA · On-site

The Sr. Clinical Trial Manager (Sr. CTM) is a hands-on program owner responsible for the end-to-end execution of assigned clinical studies within a portfolio spanning US IDE pivotal trials ...

eGenesis

Senior Clinical Trial Manager

Cambridge, MA · On-site

$142K - $176K/yr

As the Senior Clinical Trial Manager, you will be responsible for the day-to-day management of our clinical studies, vendors, and sites in alignment with corporate and program goals. You will work ...

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Senior Clinical Trial Manager information

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$125.3K

$206K

How much do senior clinical trial manager jobs pay per year?

As of Aug 26, 2026, the average yearly pay for senior clinical trial manager in the United States is $125,290.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,000.00 and $157,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a senior clinical trial manager?

To thrive as a Senior Clinical Trial Manager, you need expertise in clinical trial operations, regulatory compliance, and project management, typically supported by a degree in life sciences or a related field and several years of clinical research experience. Familiarity with electronic data capture (EDC) systems, clinical trial management systems (CTMS), and certifications such as ACRP or SOCRA are often required. Exceptional leadership, problem-solving, and communication skills help manage teams, stakeholders, and complex timelines. These skills and qualities are critical to ensure trials are conducted efficiently, ethically, and in compliance with regulatory standards.

How does a senior clinical trial manager typically collaborate with cross-functional teams during a clinical study?

A Senior Clinical Trial Manager regularly works with cross-functional teams, including data management, regulatory affairs, biostatistics, and clinical operations, to ensure seamless execution of clinical studies. They facilitate communication between departments to address challenges, monitor study progress, and ensure compliance with protocols and regulatory requirements. This collaboration is essential for timely trial delivery and maintaining data integrity, as well as for problem-solving and decision-making throughout the study lifecycle.

What is the difference between Senior Clinical Trial Manager vs Clinical Trial Coordinator?

AspectSenior Clinical Trial ManagerClinical Trial Coordinator
ResponsibilitiesOversees entire trial process, manages teams, ensures complianceAssists with trial logistics, manages documentation, supports trial staff
Required CredentialsTypically requires a Bachelor's/Master's in life sciences, experience in trial managementUsually requires a Bachelor's in health sciences or related field
Work EnvironmentLeads trial teams, interacts with sponsors, regulatory bodiesSupports trial operations, coordinates between sites and teams
Industry UsageCommonly employed in pharmaceutical and biotech companiesOften found in clinical research sites and CROs

The main difference is that the Senior Clinical Trial Manager has a leadership role overseeing the entire trial process, while the Clinical Trial Coordinator provides operational support. The manager handles strategic planning and team management, whereas the coordinator focuses on day-to-day trial activities.

What does a senior clinical trial manager do?

A senior clinical trial manager oversees the planning, execution, and monitoring of clinical trials to ensure they comply with regulatory standards and protocols. They coordinate with cross-functional teams, manage budgets and timelines, and ensure data quality and safety throughout the trial process. Strong project management skills and knowledge of Good Clinical Practice (GCP) are essential for this role.
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Senior Clinical Trial Manager jobs near you
Infographic showing various Senior Clinical Trial Manager job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 81% Physical, 2% Hybrid, and 17% Remote job distribution, with an average salary of $125,290 per year, or $60.2 per hour.

Clinical Trial Manager/ Sr. Clinical Trial Manager

Cambridge, MA • On-site

City Therapeutics
See more jobs at City Therapeuticsexternal

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 16 days ago

Job description

Clinical Trial Manager/ Sr. Clinical Trial Manager
At City Tx, we're building the next generation of siRNA medicines-and a team bold enough to redefine what RNA therapeutics can do. We are pushing the science further and translating breakthrough ideas into meaningful medicines for patients.
We're looking for curiosity, and a willingness to roll up your sleeves and contribute wherever you can make an impact. We are looking for people who embrace ambitious challenges, move with purpose, collaborate generously, and are excited to help build both breakthrough medicines and an exceptional company. If you're energized by ambitious science, meaningful problems, and the opportunity to build something from the ground up, we'd love to hear from you.
We are seeking a motivated Clinical Trial Manager / Senior Clinical Trial Manager (CTM/Sr. CTM) to lead the cross-functional Clinical Study Team, plan and manage the operational aspects of assigned clinical trials ensuring their successful delivery.. In this role, you will serve as the primary point of contact for study leadership, providing strategic direction and operational oversight from endorsement and start-up through execution, close-out, and reporting.
You will partner closely with internal stakeholders, CROs, Investigators/clinical sites and external vendors to deliver Phase 1 dose-escalation through later-phase global clinical trials on time and within budget,, ensuring quality and compliance with ICH-GCP and regulatory requirements.
This is a full-time onsite opportunity
Responsibilities:
  • Plan and manage the operational aspects of clinical trials throughout the trial's lifecycle (study start-up, execution and maintenance, close-out, and reporting), ensuring that milestones, objectives, and deliverables are aligned with the Clinical Development Plan and program and company goals.
  • Lead cross-functional clinical study teams and serve as the primary point of contact for trial-related activities and updates to internal leadership.
  • Contribute to clinical trial strategy, including supporting protocol development, country and site selection, vendor identification, risk management, and development of study timelines and budgets.
  • Oversee the development and maintenance of key study documents such as informed consent forms, study management plans, submission packages, GDPR compliance materials, and annual reports.
  • Drive vendor and CRO performance through oversight plans, performance tracking, and issue resolution.
  • Foster strong partnerships with investigators, site staff, external partners and internal stakeholders to support efficient study execution and achievement of enrollment and delivery targets.
  • Identify and proactively manage study risks with mitigation strategies and appropriate escalation. Ensure compliance with GCP, SOPs, and regulatory requirements across all operational activities. Champion inspection readiness and support audits and regulatory inspections, including CAPA development.
  • Lead the study-level budgeting and site contracting process, in partnership with legal and finance teams. Monitor vendor financial performance and review invoices, change orders, and scopes of work to ensure financial accountability.
  • Oversee CRO management of the Trial Master File (TMF), ensuring completeness and quality. Ensure timely and accurate registration and updates in clinical trial registries (e.g., ClinicalTrials.gov).
  • Identify and implement opportunities to improve clinical operations processes and drive efficiency. Contribute to departmental goals and strategic initiatives.

Qualifications:
  • Bachelor's degree in a life sciences or healthcare-related discipline (advanced degree a plus).
  • Minimum of 6 years of experience in clinical trial management within biotech or pharmaceutical industry.
  • Strong project management skills with a proactive, solutions-oriented mindset.
  • Excellent interpersonal, communication, and organizational skills.
  • Proven ability to manage vendors and CROs, driving accountability and high-quality deliverables.
  • Deep knowledge of clinical trial regulations and guidelines (ICH-GCP, FDA, EMA, etc.).
  • Ability to work independently and collaboratively in a dynamic, cross-functional team environment.
  • Willingness to travel up to 15%, including international travel.

City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment Agency inquiries or submissions will not be accepted at this time.
Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match. Per Year Salary Range: $164,000 to $185,000
City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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